Hi Gerhard,
What is your setup there, what transceiver are you using?
I'm also in Win10 and everything works ok (Hermes).
If you use VAC1 so to have mic and speaker, then this is always getting disabled when RADE is enabled, it is written in the Thetis_RADE_Instructions.pdf file.
If you do use VAC, I have not tested the VAC case yet, since Thetis-RADE in these first versions is meant for eliminating VAC usage for external RADE apps, you can test it though yourself by after enbling RADE, do a VAC1 enable, but remember that when RADE gets re-enabled/checked, it will uncheck VAC1 again.
73,
Christos SV1EIA