Body First

[Lola Bergo]

FirstBody is a premier med spa in Alpharetta, GA that specializes in advanced treatments to Firm, Invigorate, Rejuvenate, Sculpt, and Tone your skin and body. Led by Dr. Arnaldo Jimenez, our practice specializes in dermal filler injections, medical weight loss, and nonsurgical cellulite reduction. We're also thrilled to provide body contouring, RF microneedling, and sexual wellness treatments for patients all over Milton, Alpharetta, and the Greater North Atlanta area. Our staff is committed to providing excellent care using reliable methods and sophisticated technology to accomplish that aim. We are committed to empowering and uplifting our clients, whatever their needs are.

Dr. Arnaldo Jimenez is the owner and lead provider at First Body. He has decades of healthcare experience and specializes in nonsurgical aesthetic treatments such as EMSCULPT NEO body contouring, EMSELLA sexual health therapy, and RF microneedling. With his expertise and passion for lifting up our clients, you can trust Dr. Jimenez to provide you with the high grade of care that you deserve.

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Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of post mortem cases, the distribution of Lewy pathology seems to follow two overarching patterns: a caudo-rostral pattern with relatively more pathology in the brainstem than in the telencephalon, and an amygdala-centered pattern with the most abundant pathology in the "center of the brain", including the amygdala, entorhinal cortex, and substantia nigra, and relatively less pathology in the lower brainstem and spinal autonomic nuclei. The recent body-first versus brain-first model of Lewy Body Disorders proposes that the initial pathogenic alpha-synuclein in some patients originates in the enteric nervous system with secondary spreading to the brain; and in other patients originates inside the CNS with secondary spreading to the lower brainstem and peripheral autonomic nervous system. Here, we use two existing post mortem datasets to explore the possibility that clinical body-first and brain-first subtypes are equivalent to the caudo-rostral and amygdala-centered patterns of Lewy pathology seen at post mortem.

We recently proposed a new disease model of Parkinson's disease - the a-Synuclein Origin site and Connectome model. The model posits that the initial pathology starts either in the olfactory bulb or amygdala leading to a brain-first subtype, or in the enteric nervous system leading to a body-first subtype. These subtypes should be distinguishable early in the disease course on a range of imaging, clinical, and neuropathological markers. Here, we review recent original human studies, which tested the predictions of the model. Molecular imaging studies were generally in agreement with the model, whereas structural imaging studies, such as MRI volumetry, showed conflicting findings. Most large-scale clinical studies were supportive, reporting clustering of relevant markers of the body-first subtype, including REM-sleep behavior disorder, constipation, autonomic dysfunction, neuropsychiatric symptoms, and cognitive impairment. Finally, studies of a-synuclein deposition in antemortem and postmortem tissues revealed distribution of pathology, which generally supports the model.

BodyFirst recently launched, Enzo Whey Performance is one of the best and authentic supplements I have come across. It is a combination of Isolate, Hydrolysate & concentrate with added advantage of enzyme blend which helps in digestion of protein. This helps boost my muscle recovery faster.

I have been associated with BodyFirst for the past 3 years and it is the Best choice for Clean, Safe, Qualified and Authentic supplement, especially when we are surrounded by so many fake supplements in the Market. I Trust only BodyFirst, as they have a range of best health supplements which are also informed sport certified.

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I am using the BodyFirst Astaxanthin from Astareal Japan and results are superb! It improves my endurance by lowering the lactic acid levels during exercise. Most importantly it is Informed Sports Certified which assures me it is clean, safe and free from banned substances to consume!

BodyFirst brings a range of Informed Sport certified products, which are tested and approved by the Apex authority for the finest quality. This stamps our principle of providing authentic supplements and certified protein products, immunity booster supplements for good health & overall wellbeing . We cater to the nutritional needs of sports enthusiasts, fitness trainers, hobby seekers, gym goers, senior citizens, children, women, students, corporate professionals, and the entire family, building preventive wellness for good health.

BodyFirst is proudly Indian, with a home grown line of products like dietary supplements, nutritional supplements, sports nutrition, protein supplements and wellness essentials made using only the finest ingredients sourced from the best global suppliers across various countries like AstaReal, From Japanese waters, microalgae - Astaxanthin, KSM-66, Special Extraction Method used, India - Ashwagandha, Verisol, Made for cosmetic uses, Germany - Collagen, Opitac, Torula Yeast from Japan - Glutathion, Tendoguard, Avian eggshell membrane & Sternum cartilage, USA - Collagen, Evnol Suprabio, Red Palm fruits (Elaeis guineensis), Malaysia - Tocotrienol, Superba, Euphausia Superba (Antarctic Krill), Antarctica - Krill oil, Vitashine, Litchen Source, Australia - Vitamin D, Digizyme, from Sabinsa, USA - Enzyme. Our utilization of these ultra-premium ingredients in each formulation sets us apart, ensuring the unparalleled effectiveness you won't find elsewhere in the market among genuine supplement brands.

In this fast-paced, multitasking world,staying on top of our health and overall wellbeing can feel like an epic challenge. At Bodyfirst, we're on a mission to supercharge your daily nutritional game. We've got you covered with premium, authentic supplements, which are scientifically-backed nutraceutical products that are genuine supplements and help fill those nutritional gaps, offering a sleek lineup of cutting-edge products. Our products come with the prestigious Informed Sports Certification, assuring you of not just exceptional supplements but also their unwavering authenticity and genuineness. Our full range of products include Diabetes Management, Blood Sugar Management, Weight Management, Hair, Nail & Skin, Gut Health, Stress Management, Heart Health, Bone & Joint, Detox & Liver Care & Sleep & Anxiety.

The :first-child pseudo-class in body:first-child operates on the body tag, so its the body tag that is a first child of its parents that will be selected, if you want the body's first child use the child selector

To target the first div, you need to do body div:first-child. Right now (I assume) you're just selecting the first-child body. (Actually I'm not entirely sure what you're selecting right now, come to think of it. I don't think the first-child selector is valid to hang directly on the body tag.)

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In PD, brain changes extend beyond the nigrostriatal dopaminergic pathway and consequently involve several neuronal networks, causing various non-motor symptoms5. Functional changes in these networks can be examined using 18F-Fluorodeoxyglucose PET (18F-FDG PET). 18F-FDG PET studies have identified a PD-related pattern (PDRP) characterized by relatively increased glucose metabolism in the pallidum, thalamus, pons and cerebellum, and relative hypometabolism of the premotor cortex, supplementary motor area, and parietal association regions6. PDRP expression can be quantified and has been observed to increase with disease progression and decrease with symptomatic treatment7,8. Only modest correlations exist between PDRP expression and striatal binding ratios measured by 18F-FDOPA PET or DAT SPECT imaging, indicating that the PDRP reflects more widespread functional brain changes9,10,11. In contrast to dopaminergic changes, PDRP expression shows no asymmetry, even in PD patients with strictly unilateral symptoms12.

Despite clinical asymmetry being well documented, its origin and role in disease pathology are unclear. Some studies have suggested that the asymmetric onset of PD is not random but is directed by brain lateralization (i.e. hand dominance)13,14. Explanations have been sought amongst structural and biochemical hemispheric differences that may cause specific unilateral vulnerabilities for PD pathology15.

It is tempting to use a degree of asymmetry as a marker to identify PD subtypes in clinical and research settings. However, first, it is crucial to investigate whether asymmetry is indeed associated with the suggested brain/body-first subtypes. In this retrospective study, we compare the degree of asymmetry in putamen DAT binding (123I-FP-CIT SPECT), PDRP expression, regional brain glucose metabolism and motor scores between presumed body-first and brain-first PD. Based on the SOC theory, individuals without RBD, indicating the brain-first subtype (PDRBD-), would exhibit greater asymmetry in putamen DAT binding, hemispheric PDRP expression, and regional glucose metabolism (particularly in the amygdala). Conversely, we anticipate that individuals with RBD as a prodromal phase (body-first subtype, PDRBD+), as well as those presenting with iRBD (presumed prodromal phase of body-first PD), would reveal more symmetric findings in these imaging markers.

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