Found unexplained higher body weight in wild Swedish tadpoles, similar to what is found with thyroid disrupting chemicals. Carlsson, Environ Monit Assess.
Co-exposure of heavy metals (Pb, Cd, Mn, As) induced more kidney toxicity as compared to each metal alone. Rats with diabetes were more prone to kidney damage from metals compared to rats without diabetes. Riaz et al. Environ Sci Pollut Res Int.
A mixture of phthalates, triclosan, and perfluorinated compounds (designed within the EDC-MixRisk project based on serum levels of the compounds in pregnant Swedish women) affected metabolic rate, adipogenesis and lipid storage in young zebrafish fed a calorie-rich diet. Mentor et al. Chemosphere.
The pharmaceutical antibotic sulfomethoxazole is obesogenic in roundworms. Li et al. J Hazard Mater.
Low-dose BPA exposure induces cholesterol synthesis in the liver, which causes cholesterol accumulation and further induces liver lipid synthesis and hepatic steatosis. Li et al. Food Chem Toxicol.
Adult exposure to the pesticide chlorpyrifos increased food intake in mice with APOE3 and 4 genes, but only mice with the APOE4 gene had increased body weight. Basaure et al. Environ. Res.
Postmenopausal women may be at particular risk when exposed to endocrine disruptors. Ovariectomized mice were exposed to a low-dose mixture of one dioxin, one PCB, one phthalate, and BPA, and some to estrogen replacement, with interesting results too complex to summarize here. Julien et al. J Nutr Biochem.
Air Pollution
Despite the few studies included in the meta-analysis, this study found some epidemiologic evidence supporting the association between PM10 and NO2 exposures and increased triglyceride levels. Giao et al. Environ Pollut.
Type 1 Diabetes
In case you missed it under "reviews" above. The evidence "corroborates the hypothesis that environmental exposures in early life contribute to type 1 diabetes risk, whether related to maternal influences on the fetus during pregnancy, neonatal factors or later effects during infancy and early childhood. Studies to date show a range of environmental triggers acting at different time points, suggesting a multifactorial model of genetic and environmental factors in the pathogenesis of type 1 diabetes, which integrally involves a dialogue between the immune system and pancreatic beta cells." Craig et al. Diabetologia.
Total copper and ceruloplasmin levels were higher in people with type 1 diabetes compared to healthy controls; elevated copper was the strongest factor associated with type 1, resulting in a 15-fold increased odds of having the disease per standard deviation increase. Squitti et al. J Trace Elem Med Biol. |
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