Fwd: CHE diabetes/obesity: New science this week

[Sarah Howard]

Missed last week due to a conference so this is the past 2 weeks.

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View this email in your browser CHE Diabetes and Obesity News and Updates   Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Environmental Chemicals: Human Studies Prenatal exposure to multiple organochlorine compounds and childhood body mass index Using a variety of statistical approaches, prenatal exposure to various persistent organic pollutants (individually and in mixtures) was assocated with higher BMI in children (Greece). Colicino et al. Environ Epidemiol. Association between urinary polycyclic aromatic hydrocarbon metabolites and diabetes mellitus among the US population: a cross-sectional study Found a positive association between PAH exposure levels and diabetes using NHANES data. Mallah et al. Int Health. Lipoprotein profiles associated with exposure to poly- and perfluoroalkyl substances (PFASs) in the EuroMix human biomonitoring study Found associations between cholesterol levels and various PFAS, especially in women. Papadopoulou et al. Environ Pollut.  Association of Urinary Phthalate and Phthalate Replacement Metabolite Concentrations with Serum Lipid Biomarker Levels among Pregnant Women Attending a Fertility Center Phthalate levels were associated with cholesterol/triglyceride levels in U.S. pregnant women. Mínguez-Alarcón et al. Toxics.  Pesticide Exposure in Relation to the Incidence of Abnormal Glucose Regulation: A Retrospective Cohort Study Pesticide use was associated with abnormal glucose regulation (prediabetes) in Korean farmers. Kim et al. Int J Environ Res Public Health.  Associations of polychlorinated biphenyls exposure with plasma glucose and diabetes in general Chinese population: The mediating effect of lipid peroxidation PCB exposure was associated with a higher risk of diabetes and higher fasting glucose levels. Tan et al. Environ Pollut. Environmental Chemicals: Laboratory Studies In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays Nearly all the compounds tested activated both PPARα and PPARγ in both human and rat assays, except for the FTOH compounds and PFOSA. Evans et al. Toxicol Appl Pharmacol. Prenatal Bisphenol a Exposure and Postnatal Trans Fat Diet Alter Small Intestinal Morphology and Its Global DNA Methylation in Male Sprague-Dawley Rats, Leading to Obesity Development Prenatal BPA exposure affected offspring's food intake, bodyweight, and intestinal function, although differences varied over time. Zulkifli et al. Nutrients. The Mixture of Bisphenol-A and Its Substitutes Bisphenol-S and Bisphenol-F Exerts Obesogenic Activity on Human Adipose-Derived Stem Cells A mixture of bisphenols induced lipid accumulation in stem cells, among other things; some of the effects did not occur when the bisphenols were tested individually. Reina-Pérez et al. Toxics. To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

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View this email in your browser CHE Diabetes and Obesity News and Updates

Environmental Chemicals: Laboratory Studies Air Pollution

Environmental Chemicals: Laboratory Studies

The alternative analog plasticizer BPS displays similar phenotypic and metabolomic responses to BPA in HepG2 and INS-1E cells BPS and BPA both affect pancreatic beta cells at the highest dose. Ferreira Azevedo et al. Food Chem Toxicol. Perfluorooctanoic acid promotes pancreatic β cell dysfunction and apoptosis through ER stress and the ATF4/CHOP/TRIB3 pathway High doses of PFOA killed beta cells, while low doses inhibited insulin secretion. He et al. Environ Sci Pollut Res Int.  Melatonin protects against nonylphenol caused pancreatic β-cells damage through MDM2-P53-P21 axis In vitro study. Tao et al. Toxicol Res (Camb).  Tris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases The flame retardant TCEP promoted body weight gain, high triglycerides, and fatty liver at high doses in adult mice. Yang et al. Chem Biol Interact. Air Pollution Ambient Air Pollution Associated with Body Fat Percentages at Different Body Compartments: A Cohort Study of UK Biobank Participants A previous study of the UK Biobank cohort found significant positive associations of air pollution with BMI, overall body fat percentage, and waist to hip ratio; this study found that the associations were stronger in people's arms and trunk but less evident in their legs. Cai et al. Environ Health Perspect.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

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[Sarah Howard]

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View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies

Environmental Chemicals: Laboratory Studies Air Pollution

Reviews The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence Most studies found that prenatal exposure to low BPA concentrations correlated with alterations in metabolic parameters in childhood and an increased risk of metabolic diseases such as obesity and type 2 diabetes in adulthood. Abulehia et al. Nutrients. The Association between Urinary Polycyclic Aromatic Hydrocarbons Metabolites and Type 2 Diabetes Mellitus The risk of diabetes was higher in those with higher PAH exposures. Wang et al. Int J Environ Res Public Health. Environmental Chemicals: Human Studies Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children Data from six European countries showed an increased risk of liver injury with prenatal exposure to organochlorine pesticides, PBDEs, perfluoroalkyl substances, and metals (and a decreased risk for high-molecular-weight phthalates and phenols), implying that prenatal exposure to some EDCs constitutes a potential risk factor for pediatric nonalcoholic fatty liver disease. Midya et al. JAMA Netw Open. The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships Found genes linked to certain pathways affected by heavy metals. Nguyen and Kim, Biol Trace Elem Res.

Environmental Chemicals: Laboratory Studies

An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice Used outbred mice for genetic variation. Xenakis et al. Mamm Genome. In utero exposure to Decabromodiphenyl ethane causes rapid growth in mice cubs by activating glycogenolysis and lipid synthesis Exposure to high levels of this flame retardant in utero caused cubs to be smaller at birth and grow rapidly during lactation. Yan et al. Toxicol Lett. Developmental programming: Impact of prenatal bisphenol-A exposure on liver and muscle transcriptome of female sheep Looked at transcriptional changes caused by prenatal BPA exposure. Puttabyatappa et al. Toxicol Appl Pharmacol. Does bisphenol-A affect alteration of gut microbiome after bariatric/metabolic surgery? A comparative metagenomic analysis in a long-term high-fat diet induced-obesity rat model In rats, BPA was a risk factor for obesity and may contribute to glucose intolerance, but it did not affect alterations of gut microbiome after bariatric/metabolic surgery. Son et al. Ann Surg Treat Res. Air Pollution Estimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM 2·5 air pollution, 1990-2019: an analysis of data from the Global Burden of Disease Study 2019 Estimates that about a fifth of the global burden of type 2 diabetes is attributable to PM2·5 pollution. GBD 2019 Diabetes and Air Pollution Collaborators, Lancet Planet Health.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book