Fwd: HEEDS Research Roundup: Diabetes and Obesity

[Sarah Howard]

Hello all,

I am forwarding the email below, my weekly summary of studies, but it would be preferable if you want to see it if you sign up directly. Then it won't get lost in the internet somewhere. I used to send it out via CHE, and now it is switching to HEEDS.

thanks!

Sarah

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Feb. 3-9, 2023

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View this email in your browser Week of Feb. 3-9, 2023 Welcome! Welcome to this newsletter, which will now be sent out via Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences. It includes a summary of new studies published each week on environmental chemicals and diabetes and obesity, compiled from PubMed. Environmental Chemicals: Human Studies Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: A nationally representative cross-sectional study. Legacy and emerging PFAS were associated with cholesterol levels and dyslipidemia (high LDL, high total cholesterol, low HDL), and their effects on total cholesterol were strongest (China). Wu et al. Environ Int. Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN). Among White women, higher concentrations of numerous phthalates were associated with increased diabetes incidence over 6 years. Phthalates were not associated with diabetes incidence in Black or Asian women (U.S.). Peng et al. J Clin Endocrinol Metab. See related article, Phthalates Exposure Tied to Higher Incidence of Type 2 Diabetes in White Women, in Medpage Today. Environmental Chemicals: Laboratory Studies Nafion by-product 2 disturbs lipid homeostasis in zebrafish embryo A novel polyfluoroalkyl substance, Nafion by-product 2 disrupted cholesterol and triglyceride levels, and more, in zebrafish embryos. Gui et al. Environ Pollut. 2,2',4,4',5,5'-Hexabromophenyl ether (BDE-153) causes abnormal insulin secretion and disorders of glucose and lipid metabolism in mice While the flame retardant BDE-153 decreased body weight in adult male mice, it also caused lipid accumulation in liver cells, affected insulin secretion, and caused disordered glucose metabolism. Liu et al. J Chin Med Assoc. The effect and a mechanistic evaluation of polystyrene nanoplastics on a mouse model of type 2 diabetes Exposure to polystyrne nanoplastics alone induced an increase in blood glucose, glucose intolerance and insulin resistance in mice, while combining that with a high-fat diet and streptozocin made it all worse. Wang et al. Food Chem Toxicol. Co-expression analysis of lncRNA and mRNA identifies potential adipogenesis regulatory non-coding RNAs involved in the transgenerational effects of tributyltin 74 Long non-coding RNAs were differentially expressed in gonadal white adipose tissue from adult males of the F4 generation, compared to controls. Lopes et al. PLoS One. miR-223 Plays A Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity Tributyltin induced microRNA-223 expression and increased adipogenesis in mesenchymal stem cells through the PPARγ pathway. Chang et al. Endocrinology. 2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors. 2,4-DTBP could act as an obesogen and endocrine disruptor. Ren et al. Endocrinology. Air Pollution Association of exposure to air pollutants with gestational diabetes mellitus in Chiayi City, Taiwan Exposure to PM2.5 was associated with an increased risk of gestational diabetes, especially in women who were younger or had a normal body mass index. Yan et al. Front Endocrinol (Lausanne). Donate to HEEDS We appreciate any and all donations! Your support helps make all our work possible. HEEDS is a program of Environmental Health Sciences. Thank you! Donate here Healthy Environment and Endocrine Disruptor Strategies HEEDS.org In...@heeds.org Forward to a friend Copyright © 2023 Environmental Health Sciences, All rights reserved. Our mailing address is: Environmental Health Sciences, 614 W. Lamme St., Bozeman, Montana 59715, United States