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CHE Diabetes and Obesity News
and Updates
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Reviews
This review finds that higher type 1 diabetes incidence is associated with vitamin D deficiency, a colder climate, and pollution of the environment, as well as with infections, including COVID-19. Zorena et al. Biology (Basel).
This review finds that the replacements are comparable to the original. Oliviero et al. Int J Mol Sci.
Reviews the effects of arsenic on metabolic diseases including diabetes and obesity. Ro et al. Antioxidants (Basel).
This review focuses on underappreciated factors that may contribute to obesity, including endocrine disrupting chemicals. Catalán et al. Nutrients.
Organochlorine pesticide exposure is associated with a higher risk of metabolic syndrome. Lamat et al. Environ Pollut.
Environmental Chemicals: Human Studies
Found that low to medium levels of arsenic increased diabetes risk. Fan et al. Arch Toxicol.
Among Massachusetts pregnant women, urinary concentrations of bisphenol A and propylparaben were associated with higher serum levels of total, non-HDL and LDL cholesterol. Mínguez-Alarcón et al. Sci Total Environ.
"We observed associations between prenatal exposure to phthalates and lower weight at birth but not at childhood follow-up visits. However, for adiposity, we observed an interesting pattern of association with low adiposity at delivery as well as high adiposity at 3-4 years of age." (U.S.). Ferguson et al. EHP.
"While most associations were weak, exposure to certain phthalates during gestation and childhood may be associated with adolescent body composition, particularly lean mass." (Cincinnati, Ohio). Etzel et al. Environ Res.
One organophosphate metabolite was positively associated with insulin resistance and type 2 diabetes (U.S.). Bo and Zhu, Chemosphere.
Found positive associations for cobalt and tin, and inverse for strontium (U.S.). Yang et al. Nutrients.
Childhood exposure to POPs is associated with dysregulated glucose metabolism (California). Baumert et al. Environ Res.
Prenatal chlordecone exposure tended to be associated with increased adiposity at seven years of age, particularly in boys. Costet et al. Environ Health.
Environmental Chemicals: Laboratory Studies
The transgenerational disease observed was similar for all exposures (pesticides, BPA, phthalates, dioxin, etc.) and includes pathologies of the kidney, prostate, and testis, pubertal abnormalities, and obesity. "A novel multiscale systems biology basis of disease etiology is proposed involving an integration of environmental epigenetics, genetics and generational toxicology." Beck et al. Sci Rep.
The authors screened a variety of environmental chemicals using two different lines of pancreatic beta cells. Most of the tested chemicals have detectable, deleterious effects on glucose-stimulated insulin release, insulin content, electrical activity, gene expression, or cell viability. Al-Abdulla et al. Int J Mol Sci.
A number of flame retardants had effects on fat cells. Liu et al. Environ Pollut.
I think this study is trying to figure out why estrogen protects beta cells, and yet the estrogenic BPA can kill beta cells. Babiloni-Chust et al. Environ Int.
DEHP caused insulin resistance, which was reversed by the drug verapamil. Zhang et al. Food Chem Toxicol.
Chronic arsenic exposure caused metabolic disorders in mice including impaired glucose metabolism and decreased energy expenditure. He et al. J Hazard Mater.
Air Pollution
While the incidence of type 2 is declining, higher air pollution was linked to less of a decline. Riches et al. Environ Res.
The meta-analysis indicated that air pollutants were correlated with childhood obesity and weight gain. Huang et al. Int J Environ Res Public Health.
Air pollution was positively associated with gestational diabetes risk. Zou et al. Int J Hyg Environ Health.
In India, long term air pollution exposure was associated with impaired fasting glucose, impaired glucose tolerance, and prevalence of diabetes. Gupta et al. J Assoc Physicians India.
Chemicals and the Gut
Looks into the mechanisms involved and interactions between the gut microbiome, dioxin, liver, and glucose intorelance. Massey et al. Metabolites.
To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org
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