New study on prenatal exposure to PFAS and type 1 diabetes
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Sarah Howard
Jul 8, 2020, 10:17:29 AM7/8/20
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Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes
McGlinchey A, Sinioja T, Lamichhane S, et al. [published online ahead of print, 2020 Jul 4]. Environ Int. 2020;143:105935. doi:10.1016/j.envint.2020.105935 (Note that Finland has the highest incidence of type 1 diabetes in the world)
• Over last decade, increasing incidence of type 1 diabetes has stabilized in Finland.
• Stabilization of disease incidence coincides with tighter regulation of PFAS.
• High prenatal PFAS exposure associates with decreased postnatal serum phospholipids.
• High prenatal PFAS exposure associates with appearance of islet autoantibodies.
• Prenatal PFAS exposure contributes to increased postnatal risk of type 1 diabetes.Abstract:
In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.
• Over last decade, increasing incidence of type 1 diabetes has stabilized in Finland.
• Stabilization of disease incidence coincides with tighter regulation of PFAS.
• High prenatal PFAS exposure associates with decreased postnatal serum phospholipids.
• High prenatal PFAS exposure associates with appearance of islet autoantibodies.
• Prenatal PFAS exposure contributes to increased postnatal risk of type 1 diabetes.
In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.
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