Fwd: CHE diabetes/obesity: New science this week

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates   Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution Environmental Chemicals: Human Studies High exposure to phthalates is associated with HbA1c worsening in type 2 diabetes subjects with and without edentulism: a prospective pilot study Higher phthalates exposure (both individually and mixtures) was associated with higher long-term average blood glucose levels (HbA1c) in people with type 2 diabetes (Italy). Mengozzi et al. Diabetol Metab Syndr.  Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases Cadmium, mercury, and lead were positive correlated with liver enzymes and NAFLD indices in Korean adults. Duc and Kim, Environ Pollut. Environmental Chemicals: Laboratory Studies Microplastics and di (2-ethylhexyl) phthalate synergistically induce apoptosis in mouse pancreas through the GRP78/CHOP/Bcl-2 pathway activated by oxidative stress In beta cells in vitro and in mice in vivo, microplastics and phthalates combined synergistically to cause beta cell death and oxidative stress. Wang et al. Food Chem Toxicol. Distinct responses from triglyceride and cholesterol metabolism in common carp (Cyprinus carpio) upon environmental cadmium exposure Environmental exposure to cadmium perturbed lipid metabolism involving hepatic triglyceride and cholesterol homeostasis, which could contribute to non-alcoholic fatty liver disease (NAFLD). Guo et al. Aquat Toxicol.  Investigation of obesogenic effects of hexachlorobenzene, DDT and DDE in male rats Both DDT and DDE reduce the browning of white adipose tissue and have obesogenic effects in adult male rats. Al-Obaidi et al. Gen Comp Endocrinol.  Atrazine Exposure Induces Hepatic Metabolism Disorder in Male Adult Zebrafish Atrazine exposure affected triglyceride and cholesterol levels in zebrafish. Zhang et al. Toxics. Air Pollution Role of liver enzymes in the relationship between particulate matter exposure and diabetes risk: a longitudinal cohort study Particulate matter exposure was positively associated with an increased risk of diabetes, partially mediated by some liver enzymes (China). Wang et al. J Clin Endocrinol Metab. Physical activity attenuated the association of ambient ozone with type 2 diabetes mellitus and fasting blood glucose among rural Chinese population Long-term exposure to ozone was associated with a higher risk of type 2 diabetes and higher fasting glucose levels, and that physical activity reduced those risks. Liu et al. Environ Sci Pollut Res Int. Exposure to ultrafine particles and childhood obesity: A cross-sectional analysis of the Seven Northeast Cities (SNEC) Study in China This large study found that long-term particulate matter exposure (of all sizes, ultra-fine to coarse) was associated with a greater likelihood of childhood obesity, and stronger associations on BMI were found in boys and in children living close to roads. Wu et al. Sci Total Environ. To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews

Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution

Type 1 Diabetes Reviews Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming Reviews the links between prenatal air pollution exposure, development of the hypothalamus, and how that may impact diabetes and obesity. Koshko et al. Front Endocrinol (Lausanne).

Environmental Chemicals: Human Studies

The Association between Blood Concentrations of PCDD/DFs, DL-PCBs and the Risk of Type 2 Diabetes Mellitus and Thyroid Cancer in South Korea Type 2 diabetes and thyroid cancer were associated with blood concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) but not dioxin-like PCBs, in women and not men. Lee et al. Int J Environ Res Public Health.

Environmental Chemicals: Laboratory Studies

Metabolism toxicity and susceptibility of decabromodiphenyl ether (BDE-209) exposure on BRL cells with insulin resistance BDE-209 inhibited glucose absorption, increased the levels of total cholesterol and triglycerides, and damaged liver cells with insulin resistance. Mao et al. Environ Sci Pollut Res Int. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice Triclosan caused fatty liver in young mice. Weber et al. Nat Commun. CYP1A1, VEGFA and Adipokine Responses of Human Adipocytes Co-exposed to PCB126 and Hypoxia Hypoxia my be able to affect PCB metabolism and toxicity in adipose tissue. Amine et al. Cells. Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood In mice, early life, short-term PCB 126 exposure resulted in metabolic abnormalities and altered gut bacteria in adulthood. Tian et al. Int J Mol Sci. Air Pollution Chemical constituents of ambient fine particulate matter and obesity among school-aged children: A representative national study in China Specific constituents of PM2.5 were associated with an increased BMI and childhood obesity, especially black carbon. Guo et al. Sci Total Environ. Type 1 Diabetes Association between new onset type 1 diabetes and real-world antibiotics and neonicotinoids' exposure-related gut microbiota perturbation Higher exposure to antibiotics and neonicotinoid pesticides (individually and combined) were found in children with new-onset type 1 diabetes as compared to healthy controls, and these exposures were also associated with changes in gut microbiota (China). Xu et al. World J Pediatr.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution

Reviews Environmental obesogen: More considerations about the potential cause of obesity epidemic Not a full review but a brief overview. Sun et al. Ecotoxicol Environ Saf.

Environmental Chemicals: Human Studies

Urinary polycyclic aromatic hydrocarbon excretion and regional body fat distribution: evidence from the U.S. National Health and Nutrition Examination Survey 2001-2016 In US adults, certain PAHs are significantly associated with higher body fat contents among non-Hispanic Blacks and Hispanics but not non-Hispanic Whites, and PAH levels were highest in minorities as well. Wang et al. Environ Health.

Environmental Chemicals: Laboratory Studies

Bidirectional regulation of BDE-47 on 3T3-L1 cell differentiation based on a restricted cubic spline model The flame retardant BDE-47 promoted the differentiation of fat cells, with the highest and lowest doses having the strongest effect. Liu et al. Toxicol Ind Health. Perinatal exposure to environmental endocrine disruptor bisphenol A aggravates the onset of non-alcoholic fatty liver disease (NAFLD) in weanling F1 offspring of obese rats ... including higher weight gain and inflammation. Dabeer and Raisuddin, Environ Sci Pollut Res Int. Air Pollution Ambient air pollution, lifestyle, and genetic predisposition associated with type 2 diabetes: Findings from a national prospective cohort study Data from the large UK Biobank study showed that the associations between air pollution and type 2 diabetes were stronger among individuals with an unhealthier lifestyle. Li et al. Sci Total Environ. Moderate aerobic training is safe and improves glucose intolerance induced by the association of high fat diet and air pollution In mice, moderate aerobic exercise attenuated weight gain and glucose intolerance and prevented muscle and pancreatic mass loss induced by a high-fat diet and air pollution exposure. Dos Santos et al. Environ Sci Pollut Res Int. Association between air pollution exposure and gestational diabetes mellitus in pregnant women: a retrospective cohort study Found associations between various air pollutants and gestational diabetes, although the associations were inconsistent over different trimesters. Liu et al. Environ Sci Pollut Res Int. The impact of long-term exposure to PM10, SO2, O3, NO2, and CO on incident dysglycemia: a population-based cohort study Higher exposure to SO2, O3, and PM10 were significantly associated with a higher risk of dysglycemia, impaired fasting glucose, and diabetes incidence in 12 years of follow up, especially in non-smokers and people under 45 (Iran). Tamehri Zadeh et al. Environ Sci Pollut Res Int.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution Reviews

Association between per- and polyfluoroalkyl substances exposure and risk of diabetes: a systematic review and meta-analysis This systematic review and meta-analysis of 22 studies found that associations between PFAS exposure and type 2 diabetes were consistent in cohort studies, while the associations were almost non-significant in case-control and cross-sectional studies, and concluded that PFAS exposure may increase the risk of type 2 diabetes. There was a non-linear association between PFOA exposure and type 2 diabetes risk. Gui et al. J Expo Sci Environ Epidemiol. Perfluoroalkyl substances and lipid concentrations in the blood: A systematic review of epidemiological studies This systematic review of 58 (!) articles found that PFAS exposure is associated with higher levels of LDL, HDL, and total cholesterol, particularly for PFOA and PFNA with LDL cholesterol, and PFOA and PFOS with total cholesterol. Associations between PFAS and triglycerides tended to be negative, especially for PFUnDA. Ho et al. Sci Total Environ. Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors This review describes the biological processes by which environmental chemicals contribute to the development of metabolic diseases, and an overview of their effects on various organs such as the gut and the pancreas. Bernal et al. FEBS Lett.

Environmental Chemicals: Human Studies

Physical activity modifies the relation between gestational perfluorooctanoic acid exposure and adolescent cardiometabolic risk. Childhood physical activity modified associations of prenatal PFOA concentrations with children's cardiometabolic risk at age 12: higher PFOA levels was associated with worse cardiometabolic risk scores among children with lower physical activity, but not among those with higher physical activity. Diet, however, did not modify the associations, nor did diet or physical activity modify associations with other PFAS (Ohio). Braun et al. Environ Res. Lead exposure and impaired glucose homeostasis in Chinese adults: A repeated measures study with 5 years of follow-up Higher lead levels were associated with higher blood glucose levels and lower beta cell function, only in women. Wang et al. Ecotoxicol Environ Saf. Associations between repeated measurements of childhood triclosan exposure and physical growth at 7 years. Exposure to triclosan at ages of 5 and 7 years were positively associated with physical growth at 7 years, only in boys (China). Chen et al. Chemosphere. Analysis of environmental chemical mixtures and nonalcoholic fatty liver disease: NHANES 1999-2014 Numerous chemicals as well as their mixtures were associated with NAFLD, including metals, pesticides, phthalates, and more. Li et al. Environ Pollut. Associations between polybrominated diphenyl ethers (PBDEs) levels in adipose tissues and blood lipids in women of Shantou, China In women undergoing plastic surgery, BDE-153 and BDE-209 were associated with lower levels of triglycerides, as was BDE-190 and BDE-138 with lower total cholesterol. Diastolic blood pressure was positively correlated with BDE-28 and BDE-71. A non-linear relationship was found for BDE-138 and blood lipid levels. As the cumulative levels of PBDEs increased, the health risks of high triglycerides gradually rebounded, and the health risks of high cholesterol gradually rebounded and then declined. Zhang et al. Environ Res.

Environmental Chemicals: Laboratory Studies

Dietary exposure to polystyrene nanoplastics impairs fasting-induced lipolysis in adipose tissue from high-fat diet fed mice. In mice, polystyrene nanoplastics caused larger fat cell size, induced intestinal inflammation, and increased lipid accumulation in the liver. Shiu et al. J Hazard Mater. Di(2-ethylhexyl) Phthalate Disturbs Cholesterol Metabolism Through Oxidative Stress In Rat Liver DEHP exposure led to increased total cholesterol levels in rats. Li et al. Environ Toxicol Pharmacol. Effect of polystyrene nanoplastics on cell apoptosis, glucose metabolism, and antibacterial immunity of Eriocheir sinensis Found potential synergistic effects of nanoplastics and bacteria on immunity and glucose metabolism in crabs. Nan et al. Environ Pollut. Air Pollution Sustained air pollution exposures, fasting plasma glucose, glycated haemoglobin, prevalence and incidence of diabetes: a nationwide study in China In Chinese people over 45, exposure to particulate matter was positively associated with fasting glucose and long term blood glucose levels (HbA1c), as well as an increased risk of diabetes. Liu et al. Int J Epidemiol.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution Reviews

Environmental health influences in pregnancy and risk of gestational diabetes mellitus: a systematic review Found clear evidence for an association between gestational diabetes and air pollution, cadmium, arsenic, POPs and phthalates, but the findings regarding phenols were inconsistent. Eberle and Stichling, BMC Public Health.  Exposure to per- and polyfluoroalkyl substances (PFAS) and type 2 diabetes risk "Several studies have demonstrated associations between serum PFAS concentrations and glycemic indicators of type 2 diabetes including glucose, insulin, and HOMA-IR [insulin resistance] in adolescent and adult cohorts. In addition, some studies have shown positive associations with incident type 2 diabetes and multiple PFAS." Roth and Petriello, Front Endocrinol (Lausanne).

Environmental Chemicals: Human Studies

Exposure to multiple metals and diabetes mellitus risk in Dong ethnicity in China: from the China multi-ethnic cohort study Lead and manganese co-exposure was associated with an increased risk of diabetes, and iron and strontium with a decreased risk. Yang et al. Environ Geochem Health.

Environmental Chemicals: Laboratory Studies

An amphibian high fat diet model confirms that endocrine disruptors can induce a metabolic syndrome in wild green frogs (Pelophylax spp. complex) Benzo[a]pyrene (BaP) caused glucose intolerance and insulin resistance in green frogs... "a simple glucose-tolerance test could be used on wild anurans to identify bodies of water polluted with metabolic disruptors that could affect species fitness." Veyrenc et al. Environ Pollut. PFOS promotes hepatic lipid accumulation and steatosis in high-fat diet mice through AMPK/ACC pathway PFOS causes fat accumulation in liver cells. Ling et al. J Appl Toxicol. Air Pollution Melatonin alleviates PM 2.5 -induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress In mice, melatonin alleviated PM2.5 -induced liver metabolic dysregulation. Du et al. J Pineal Res.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution Reviews

Characterization of Potential Adverse Outcome Pathways Related to Metabolic Outcomes and Exposure to Per- and Polyfluoroalkyl Substances Using Artificial Intelligence AOP-helpFinder, a new artificial intelligence tool, was used to explore all available published literature in PubMed, and found that PFAS exposure could negatively influence all components of metabolic syndrome, either individually or as a mixture. Kaiser et al. Toxics. Editorial: Obesogens in the XXI century: Emerging health challenges This is the introductory editorial for a Research Topic that includes eight articles. Sousa et al. Front Endocrinol (Lausanne). Effect of exposure to endocrine disrupting chemicals in obesity and neurodevelopment: The genetic and microbiota link Looks at the interactions among obesity and obesogens, chemicals that disrupt the gut microbiota, and neurological development, and supports "considering genetics, EDCs exposure, and microbiota as interactive factors rather than individual contributors to the risk for developing obesity and neurodevelopmental disabilities at the same time." Ramírez et al. Sci Total Environ. Exposure to organophosphates in association with the development of insulin resistance: Evidence from in vitro, in vivo, and clinical studies Exposure to organophosphate pesticides induces insulin resistance through the impairment of hepatic glucose metabolism, pancreatic damage, and disruption of insulin signaling of both adipose tissues and skeletal muscles. Seesen et al. Food Chem Toxicol.

Environmental Chemicals: Human Studies

Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study This prospective, multinational, observational fetal study, conducted in maternity units in Brazil, Kenya, Pakistan, South Africa, Thailand, and the UK, collected early pregnancy maternal blood and umbilical cord venous blood samples for untargeted metabolomic analysis, and followed children until age 2. It found that early pregnancy lipid biology associated with fetal abdominal growth trajectories was an indicator of patterns of growth and adiposity, and that the fungicide chlorothalonil was highly abundant in the early accelerating growth phenotype group. Villar et al. Lancet Diabetes Endocrinol. Prenatal exposure to per- and polyfluoroalkyl substances and childhood adiposity at 7 years of age Prenatal PFAS mixtures were generally associated with lower body weight measures in boys, and higher in girls (China). Zhang et al. Chemosphere. Sex Differences between Urinary Phthalate Metabolites and Metabolic Syndrome in Adults: A Cross-Sectional Taiwan Biobank Study Higher concentrations of MEP metabolites were associated with increased odds of metabolic syndrome in men. Postmenopausal women with higher ∑DEHP concentrations had more than nine-fold higher odds of metabolic syndrome compared with postmenopausal women with the lowest ∑DEHP concentrations. Shih et al. Int J Environ Res Public Health. Association between serum pyrethroid insecticide levels and incident type 2 diabetes risk: a nested case-control study in Dongfeng-Tongji cohort High concentrations of serum pyrethroid insecticides were significantly associated with an increased risk of incident type 2 diabetes, largely due to fenvalerate (China). Jia et al. Eur J Epidemiol. Maternal urinary organophosphate ester metabolite concentrations and glucose tolerance during pregnancy: The HOME Study Pregnant women with higher exposure to diphenyl phosphate (DPHP) had a lower risk of high blood glucose levels (Ohio). Yang et al. Int J Hyg Environ Health. Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort In Denmark, pregnancy plasma PFOA concentrations were associated with lower birth size and BMI and increased childhood height. Pregnancy plasma PFOS concentrations were also associated with lower birth BMI, but in childhood pregnancy plasma PFOS concentration interacted with child sex on BMI and fat percentage at 6 years with negative associations in girls and positive in boys. Sevelsted et al. EBioMedicine. Mixed exposure to phenol, parabens, pesticides, and phthalates and insulin resistance in NHANES: A mixture approach A chemical mixture (nine common chemicals-- one phenol, two parabens, two chlorophenols and four phthalates) had positive joint effects on insulin resistance, with DEHP being the predominant driver. Bai et al. Sci Total Environ. Trimester-specific phthalate exposures in pregnancy are associated with circulating metabolites in children Used untargeted metabolomics analysis to assess circulating metabolites in order to characterize biochemical pathways by which early life exposures influence the development of cardiometabolic risk during childhood and adolescence, prior to becoming evident in clinical markers. Found associations between various exposures and various metabolites in all children, which varied by sex and timing of exposure (Mexico). Goodrich et al. PLoS One.

Environmental Chemicals: Laboratory Studies

Early-life perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) exposure cause obesity by disrupting fatty acids metabolism and enhancing triglyceride synthesis in Caenorhabditis elegans Low concentrations of PFOA and PFOS induced obesity in C. elegans, which was not due to an increased feeding rate. Lin et al. Aquat Toxicol. Preclinical insights into fucoidan as a nutraceutical compound against perfluorooctanoic acid-associated obesity via targeting endoplasmic reticulum stress Fucoidan, found in seaweed, is a potential nutraceutical product against PFOA-associated obesity. Liu et al. Front Nutr. Induction of transgenerational toxicity is associated with the activated germline insulin signals in nematodes exposed to nanoplastic at predicted environmental concentrations Exposure to polystyrene nanoparticles upregulated the expression of insulin ligands, and this increase was also detected in the offspring. Liu et al. Ecotoxicol Environ Saf. Air Pollution Intrauterine and Extrauterine Environmental PM 2.5 Exposure Is Associated with Overweight/Obesity (O/O) in Children Aged 6 to 59 Months from Lima, Peru: A Case-Control Study In Lima, Peru, higher levels of PM2.5 were associated with overweight and obesity in children from 6 to 59 months, with the association greater for prenatal exposure. Paz-Aparicio et al. Toxics. Ozone exposure induced risk of gestational diabetes mellitus O3 exposure during both pre-pregnancy and pregnancy was associated with a higher risk of gestational diabetes (China). Li et al. Chemosphere.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies

Reviews Multigenerational metabolic disruption: Developmental origins and mechanisms of propagation across generations Reviews historical and current knowledge on the effect of exposure to environmental factors during in utero development and discusses mechanisms for these disorders to be propagated across generations. Davis et al. Front Toxicol.

Environmental Chemicals: Human Studies

Association between urinary concentrations of bisphenol A substitutes and diabetes in adults Using U.S. NHANES data, found an association between BPS exposure and diabetes risk, but not BPF exposure. Moreno-Gómez-Toledano et al. World J Diabetes. Associations of multiple plasma metals with chronic kidney disease in patients with diabetes Plasma levels of zinc, arsenic, and rubidium had a positive association with incident chronic kidney disease (CKD) risk in people with diabetes, while titanium, cadmium, and lead had an inverse correlation. Co-exposure to multiple metals was associated with increased CKD risk in people with diabetes (China). Wang et al. Ecotoxicol Environ Saf. Environmental Chemicals: Laboratory Studies Per- and Polyfluoroalkyl Substances (PFASs) Impair Lipid Metabolism in Rana nigromaculata: A Field Investigation and Laboratory Study In black-spotted frogs, PFAS disrupt liver lipids. Lin et al. Environ Sci Technol.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies

Air Pollution Wildlife Reviews Maternal Supplementation of Probiotics, Prebiotics or Postbiotics to Prevent Offspring Metabolic Syndrome: The Gap between Preclinical Results and Clinical Translation Reviews the existing literature on how developmental exposure to various environmental factors (including some environmental chemicals) can induce metabolic syndrome, as well as evidence on gut microbiota-targeted reprogramming interventions to prevent this. Huang et al. Int J Mol Sci.

Environmental Chemicals: Human Studies

Exploring the relationship between blood toxic metal(oid)s and serum insulin levels through benchmark modelling of human data: Possible role of arsenic as a metabolic disruptor In women, higher levels of arsenic and mercury were associated with higher insulin levels (Serbia). Đukić-Ćosić et al. Environ Res. Drinking Water-Associated PFAS and Fluoroethers and Lipid Outcomes in the GenX Exposure Study PFNA and PFOS were associated with higher levels of total and non-HDL cholesterol, with associations larger in older adults (North Carolina). Rosen et al. EHP. Prenatal exposure to polybrominated diphenyl ethers and BMI Z-scores from 5 to 14 years Neither cord levels of individual PBDEs nor the total PBDE mixture were associated with overall BMI in childhood (New York). Kupsco et al. Environ Health. Association of serum BPA levels with changes in lipid levels and dyslipidemia risk in middle-aged and elderly Chinese This prospective study found that serum BPA was associated with total and non-HDL-cholesterol changes, and that BPA was also associated with an increased risk of high triglycerides (China). Yao et al. Ecotoxicol Environ Saf. Prenatal single and combined exposure to phthalates associated with girls' BMI trajectory in the first six years In utero  exposure to phthalates, including MEP and DEHP metabolites (MEHHP and MEOHP), especially during the third trimester, was associated with high BMI trajectories in girls in early childhood (China). Gao et al. Ecotoxicol Environ Saf. The mediating function of obesity on endocrine-disrupting chemicals and insulin resistance in children Benzophenone-3 (BP-3) levels were associated with increased risk of insulin resistance, obesity, and abdominal obesity in Chinese children. Li et al. J Pediatr Endocrinol Metab.

Environmental Chemicals: Laboratory Studies

Betaine protects against sodium arsenite-induced diabetes and hepatotoxicity in mice Arsenic causes glucose intolerance, and oxidative/inflammatory hepatic damage in mice, and betaine prevents these effects. Esfahani et al. Environ Sci Pollut Res Int.  A comparative study in healthy and diabetic mice followed the exposure of polystyrene microplastics: Differential lipid metabolism and inflammation reaction Mice with diabetes were more susceptible to the health effects of polystyrene microplastics than mice without diabetes. Liu et al. Ecotoxicol Environ Saf. Perinatal exposure to tributyltin affects feeding behavior and expression of hypothalamic neuropeptide Y in the paraventricular nucleus of adult mice Low dose TBT exposure of female mice during gestation and of pups during lactation permanently altered the feeding efficiency of pups of both sexes (and increased food consumption), and affected subcutaneous fat distribution in adult males. Ponti et al. J Anat. Sex-dependent effect of triphenyl phosphate on hepatic energy metabolism at the intersection of diet pattern in pubertal mice Females were more susceptible than males to increased energy storage due to triphenyl phosphate exposure. Liu et al. Ecotoxicol Environ Saf. Air Pollution Longitudinal Associations of Air Pollution With Body Size and Composition in Midlife Women: The Study of Women's Health Across the Nation In U.S. women, exposure to PM2.5, NO2, and O3 was associated with higher fat mass, higher proportional fat mass, and lower lean mass Wang et al. Diabetes Care. Exposure to air pollution and prevalence of metabolic syndrome: A nationwide study in China from 2011 to 2015 Higher exposure to numerous air pollutants was associated with a higher risk of metabolic syndrome. Liu et al. Sci Total Environ. Effects of long-term PM 2.5 exposure on metabolic syndrome among adults and elderly in Guangdong, China Long-term exposure to PM2.5 was associated with metabolic syndrome, dyslipidemia and impaired fasting glucose. Zheng et al. Environ Health. Wildlife Latitudinal but not elevational variation in blood glucose level is linked to life history across passerine birds Not environmental chemicals but interesting... how many researchers have measured blood glucose levels in wildlife? There was quite a variation among individual birds. Birds living at higher elevations and higher latitude tended to have higher glucose levels, while birds with higher body weight tended to have lower glucose levels. Blood glucose stress response was stronger at low latitudes and high elevations. Tomášek et al. Ecology Letters.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

I added more on type 1 this week, I'll try to keep doing that...

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution

Type 1 Diabetes Reviews

Mercury Exposure and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis People with diabetes tend to have higher mercury levels than people without diabetes, but men (not women) with higher mercury levels tend to have a lower risk of type 2 diabetes. And overall, mercury was not significantly associated with type 2 diabetes risk. Ghorbani Nejad et al. Int J Clin Pract.

Environmental Chemicals: Human Studies

Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents Prenatal exposure to the UV-filter BP3 was associated with higher BMI (non-monotonically) and higher diastolic blood pressure during preadolescence, but there was little evidence for an overall phthalate and phenol mixture effect (Spain). Güil-Oumrait et al. Environ Int.

Environmental Chemicals: Laboratory Studies

Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice Polystyrene nanoplastics caused fetal growth restriction and disturbed cholesterol metabolism in both the placenta and fetus. Chen et al. Sci Total Environ.  Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine-rich protein 2 BPA induced lipid accumulation in zebrafish with increases in triglyceride, cholesterol, and glucose levels, while WL15 peptide reduced these effects. Guru and Arockiaraj, J Biochem Mol Toxicol. Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice Long-term and low-dose exposure to PFOA and GenX disrupts lipid metabolism in mice. Whereas the effects of PFOA are mediated by multiple nuclear receptors, the effects of GenX are mediated by PPARα. Attema et al. Mol Metab. Early- and whole-life exposures to florfenicol disrupts lipid metabolism and induces obesogenic effects in zebrafish (Danio rerio) Florfenicol is a veterinary antibiotic. It was obesogenic at environmental levels, especially as a result of developmental exposure. Li et al. Chemosphere. Air Pollution Systemic inflammation accelerates the adverse effects of air pollution on metabolic syndrome: Findings from the China health and Retirement Longitudinal Study (CHARLS) In Chinese middle-aged and older adults, long-term exposure to air pollution was associated with increased prevalence of metabolic syndrome, which was enhanced by systemic inflammation. Han et al. Environ Res.  In utero particulate matter exposure in association with newborn mitochondrial ND4L 10550A>G heteroplasmy and its role in overweight during early childhood Prenatal PM2.5 exposure was positively associated with childhood overweight, mainly driven by second trimester exposure, and was not due to cord blood MT-ND4L10550A>G heteroplasmy, whatever that is (Belgium). Cosemans et al. Environ Health. Associations between ambient air pollution, obesity, and serum vitamin D status in the general population of Korean adults The annual average concentrations of PM10, NO2, and CO were associated with a lower serum vitamin D concentration. Females (not males) with obesity had a stronger association between different air pollutants and low serum vitamin D concentration (Korea). Kim et al. BMC Public Health.  Type 1 Diabetes There are so many studies on type 1 diabetes or autoimmunity and miscellaneous environmental factors that I usually don't include them at all because it would take too long to summarize them. I'm going to try to start including just the titles, which link to the abstracts if you want to check out the findings.  The etiology and pathogenesis of type 1 diabetes - A personal, non-systematic review of possible causes, and interventions. Hypothesis: Induction of Autoimmunity in Type 1 Diabetes-A Lipid Focus. Editorial: Latent Autoimmune Diabetes in Adults (LADA). [intro to a research topic on LADA] Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals with Presymptomatic Type 1 Diabetes. Guidance for high-dose vitamin D supplementation for prolonging the honeymoon phase in children and adolescents with new-onset type 1 diabetes. Progress in the Relationship between Vitamin D Deficiency and the Incidence of Type 1 Diabetes Mellitus in Children. Incidence Trends of New-Onset Diabetes in Children and Adolescents Before and During the COVID-19 Pandemic: Findings from Florida. Impacts of COVID-19 on Glycemia and Risk of Diabetic Ketoacidosis. Infections in the first year of life and development of beta cell autoimmunity and clinical type 1 diabetes in high-risk individuals: the TRIGR cohort. Rotavirus vaccination and the risk of type 1 diabetes and celiac disease: A systematic review and meta-analysis. Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes: Results from the German National Cohort. Developmental trichloroethylene exposure enhances predictive markers of autoimmunity in a sex-specific manner in disease-resistant female mice. Gestational PCB52 exposure induces hepatotoxicity and intestinal injury by activating inflammation in dam and offspring mice: A maternal and progeny study.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution Type 1 Diabetes

Environmental Chemicals: Human Studies Association of Exposure to Phthalate Metabolites With Sex Hormones, Obesity, and Metabolic Syndrome in US Women Using cross-sectional NHANES data, found that exposure to certain phthalate metabolites was associated with obesity and metabolic syndrome, depending on menopausal status. Dubey et al. JAMA Netw Open. Use of high-resolution metabolomics to assess the biological perturbations associated with maternal exposure to Bisphenol A and Bisphenol F among pregnant African American women "...exposure to BPA and BPF in pregnant women is associated with the perturbation of aromatic amino acid metabolism, xenobiotics metabolism, steroid biosynthesis, and other amino acid metabolism closely linked to stress responses, inflammation, neural development, reproduction, and weight regulation." Tchen et al. Environ Int. Gestational per- and polyfluoroalkyl substances exposure and infant body mass index trajectory in the New Hampshire Birth Cohort Study Infant girls born to mothers with higher pregnancy concentrations of PFOS had greater BMI growth during the first year of life. Romano et al. Environ Res. Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999-2018) Found a positive association between blood lead levels and hyperlipidemia (U.S.). Zhang et al. Front Public Health.

Environmental Chemicals: Laboratory Studies

Dietary zinc deficient condition increases the Bisphenol A toxicity in diabetic rat testes Sahu and Jena, Mutat Res Genet Toxicol Environ Mutagen. Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering mTOR/CRTC2/SREBP1 in male rat offspring Exposure to BPA during gestation caused higher triglyceride and total cholesterol levels in the blood and liver of male rats. Yang et al. Hum Exp Toxicol.  Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) The data provides a full transcriptional profile of changes that occur over time in preadipocytes that have been exposed to PCB126, which can be mined by other researchers to understand how PCB126 and other dioxin-like compounds affect biological pathways in preadipocytes and other cell types to cause disease. Gourronc et al. Data Brief. Probiotics protect against hepatic steatosis in tris (2-chloroethyl) phosphate-induced metabolism disorder of mice via FXR signaling Dietary complex probiotics supplements reduced TCEP-induced obesity, hyperlipidemia, liver dysfunction, and hepatic steatosis. Yang et al. Food Chem Toxicol.  Air Pollution Joint effect of multiple air pollutants on cardiometabolic health in normal-weight and obese adults: A novel insight into the role of circulating free fatty acids People with "metabolically healthy" obesity were more susceptible to the cardiometabolic effects of air pollution than those of normal weight (China). Zhang et al. Sci Total Environ. Long-term exposure to PM 2.5 constituents in relation to glucose levels and diabetes in middle-aged and older Chinese Exposures to PM2.5 and its constituents were positively associated with increased risks of prevalent diabetes and elevated glucose levels in middle-aged and older adults. Zhou et al. Ecotoxicol Environ Saf. Type 1 Diabetes Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study. Month of birth and risk of type 1 diabetes: What does it tell us? Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests. Association of SARS-CoV-2 Infection With New-Onset Type 1 Diabetes Among Pediatric Patients From 2020 to 2021. The COVID-19 Pandemic Affects Seasonality, With Increasing Cases of New-Onset Type 1 Diabetes in Children, From the Worldwide SWEET Registry. Type 1 diabetes: Global prevalence is set to double by 2040, study estimates. Trends in nationwide incidence of pediatric type 1 diabetes in Montenegro during the last 30 years. Gut Microbiota Funcional Traits, Blood pH, and Anti-GAD Antibodies Concur in the Clinical Characterization of T1D at Onset.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

sorry, late this week!

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews

Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution

Type 1 Diabetes and Autoimmunity Reviews Bisphenol A-Induced Endocrine Dysfunction and its Associated Metabolic Disorders Reviews recent developments and novel insights into the cellular and molecular mechanisms of BPA-induced  metabolic disorders. Maniradhan and Calivarathan, Endocr Metab Immune Disord Drug Targets.

Environmental Chemicals: Human Studies

Associations between serum perfluoroalkyl acid (PFAA) concentrations and health related biomarkers in firefighters In the cross-sectional analysis, higher levels of all PFAAs were significantly associated with higher levels of total and LDL-cholesterol (Australia). Nilsson et al. Environ Res. Environmental Chemicals: Laboratory Studies Apoptotic susceptibility of pancreatic alpha cells to environmentally relevant dose levels of bisphenol-A versus dibutyl phthalate is mediated by HSP60/caspase-3 expression in male albino rats Rats exposed to BPA and DBP phthalate alone or in combination (at levels found in the environment) had islet cell immunoreactivity. The combined exposure led alpha and beta cell death, and BPA alone to alpha cell death. Morsi et al. Cell Biol Int. Ancestral BPA exposure caused defects in the liver of medaka for four generations Found advanced stage non-alcoholic fatty liver disease (NAFLD) in the grandchildren (F2 generation) of medaka fish due to embryonic BPA exposure in the grandparental generation (F0), which persists for five generations (F4) even in the absence of further exposure. Chakraborty et al. Sci Total Environ. Metallothionein gene expression in rat tissues: response to dietary restriction after orally dichlorodiphenyldichloroethylene (DDE) exposure and high-fat feeding Found that metallothionein gene expression after calorie restriction is tissue-specific and strongly influenced by both previous dietary conditions and DDE exposure. Migliaccio et al. J Environ Sci Health B. Acute exposure to microplastics induces metabolic disturbances and gut dysbiosis in adult zebrafish (Danio rerio) Acute exposure to microplastics at environmentally relevant concentrations disrupted gut microbiota and metabolism in zebrafish. Medriano and Bae, Ecotoxicol Environ Saf. Annexin A1 Inhibition Facilitates NLRP3 Inflammasome Activation in Arsenic-induced Insulin Resistance in Rat Liver Shows how arsenic can cause insulin resistance. Wu et al. Environ Toxicol Pharmacol. Chronic lead exposure exacerbates hepatic glucolipid metabolism disorder and gut microbiota dysbiosis in high-fat-diet mice In mice fed a high-fat diet, lead exposure increased body weight, visceral obesity, fasting blood glucose levels, and insulin resistance; aggravated liver damage, liver lipid accumulation and steatosis; and exacerbated disruption of gut microbiota. Wang et al. Food Chem Toxicol. Air Pollution PM2.5-induced adipose tissue dysfunction can trigger metabolic disturbances A short Forum article. Della Guardia and Shin, Trends Endocrinol Metab. Long-term exposure to ambient air pollution is a risk factor for trajectory of cardiometabolic multimorbidity: A prospective study in the UK Biobank Higher air pollution levels were linked to cardiometabolic disease development, including type 2 diabetes. Luo et al. EBioMedicine.  Associations of ozone exposure with gestational diabetes mellitus and glucose homeostasis: Evidence from a birth cohort in Shanghai, China O3 exposure during pregnancy disrupts glucose homeostasis and increases the risk of gestation diabetes in pregnant women. Zhang et al. Sci Total Environ. Physical activity attenuated the associations between ambient air pollutants and metabolic syndrome (MetS): A nationwide study across 28 provinces Found that all air pollutants were positively associated with the risk of metabolic syndrome, while physical activity showed beneficial associations (China). Guo et al. Environ Pollut. Type 1 Diabetes and Autoimmunity Early glucose metabolism in children at risk for type 1 diabetes based on islet autoantibodies compared to low-risk control groups. Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification and related  Invited Perspective: Key Characteristics as a Starting Point for Improved Hazard Identification of Immunotoxic Agents. Type 1 diabetes mellitus induced by PD-1 inhibitors in China: a report of two cases. The importance of vitamin D and omega-3 PUFA supplementation: a nonpharmacologic immunomodulation strategy to halt autoimmunity Changes in the gut bacteriome upon gluten-free diet intervention do not mediate beta cell preservation. Quantifying the utility of islet autoantibody levels in the prediction of type 1 diabetes in children. Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes. Parental history of psychiatric disorders and risk of type 1 diabetes in offspring.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

Hi all, I'm gonna send these out Thursdays instead of Wednesdays now.

thx

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution

Reviews Roles of estrogens, estrogen-like compounds, and endocrine disruptors in adipocytes Reviews "the role of estrogens and their receptors on the central regulation of caloric expenditure and the influence they exert on the differentiation and function of adipocytes," and "chemical substances with a hormonal activity that cause endocrine disruption with affectation on estrogen receptors." Lizcano, Front Endocrinol (Lausanne). Diabetes and climate change "Climate change and diabetes appear to have common global vectors, including increased urbanisation, increased use of transportation, and production and ingestion of ultra-processed foods. People with diabetes appear to at higher risk of threats to health from climate change... Solutions to climate change offer some benefits for the prevention of diabetes." Al-Shihabi et al. Diabet Med. Risk of incident diabetes after COVID-19 infection: A systematic review and meta-analysis COVID-19 is strongly associated with the risk of diabetes, including both type 1 and type 2: "Ten articles involving 11 retrospective cohorts with a total of 47.1 million participants proved eligible. We found a 64 % greater risk of diabetes in patients with COVID-19 compared with non-COVID-19 controls... Type 2 diabetes has a higher relative risk than type 1... men may be at a higher risk of overall diabetes than women." Lai et al. Metabolism.

Environmental Chemicals: Human Studies

Associations of bifenthrin exposure with glucose homeostasis and type 2 diabetes mellitus in a general Chinese population: Roles of protein carbonylation Exposure to the pesticide bifenthrin exposure was dose-dependently associated with glucose dyshomeostasis in Chinese urban adults. Liang et al. Environ Pollut. Associations of lead and cadmium co-exposure with fasting plasma glucose and type 2 diabetes in Chinese adults Lead and cadmium co-exposure was significantly associated with elevated fasting glucose and type 2 diabetes in the general population. Wang et al. Diabetes Metab Res Rev.

Environmental Chemicals: Laboratory Studies

Single and combined effect of bisphenol A with high sucrose diet on the diabetic and renal tubular dysfunction phenotypes in Drosophila melanogaster BPA causes diabetes in fruit flies, sugar makes it worse, and both lead to kidney problems. Rani et al. Environ Toxicol Pharmacol. Air Pollution Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells Low concentrations of chemicals from diesel exhaust particles can modify gene expression fat cells, which may be linked to metabolic disease. Brinchmann et al. Basic Clin Pharmacol Toxicol. Association of long-term air pollution exposure with the risk of prediabetes and diabetes: Systematic perspective from inflammatory mechanisms, glucose homeostasis pathway to preventive strategies Long-term exposure to air pollution was associated with the risk of prediabetes, diabetes, and other measures of glucose dyshomeostasis (China). Mei et al. Environ Res.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution

Type 1 Diabetes Reviews

Association of Selenium Levels with Gestational Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis Selenium levels were lower among women with gestational diabetes in comparison to those without; however, after the correction of the reporting bias, the result was no longer significant. Hamdan et al. Nutrients.

Environmental Chemicals: Human Studies

Associations between Mixture of Perfluoroalkyl Substances and Lipid Profile in a Highly Exposed Adult Community in the Veneto Region Exposure to a mixture of PFAS mixture was associated with higher cholesterol levels, regardless of the three different methods used to analyze the data. All three methods showed a major contribution of PFOS and PFNA, although the main exposure was due to PFOA. Batzella et al. Int J Environ Res Public Health. Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations "The PFAS-related features did not associate with cholesterol, but 50 features were associated with triglycerides... one metabolite pattern, dominated by glycerophospholipids, correlated with longer chain PFAS and associated inversely with triglycerides (both cross-sectionally and prospectively), after adjustment for confounders. The observed time-trend of the metabolite pattern resembled that of the longer chain PFAS, with higher levels during the years 2004-2010." (Sweden). Schillemans et al. Environ Res. Associations of Diet Quality and Heavy Metals with Obesity in Adults: A Cross-Sectional Study from National Health and Nutrition Examination Survey (NHANES) The beneficial effect of a high-quality diet was weakened by higher levels of heavy metals in U.S. adults. Li et al. Nutrients. Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003-2020 Urinary arsenic and arsenic species were positively associated with increased LDL cholesterol levels (U.S.). Qu and Huang, Nutrients. Cross-Sectional Association of Blood Selenium with Glycemic Biomarkers among U.S. Adults with Normoglycemia in the National Health and Nutrition Examination Survey 2013-2016 U.S. adults without diabetes who had higher selenium levels had higher fasting glucose, HbA1c, and insulin levels. Yang et al. Nutrients. Relationship between Metal Exposures, Dietary Macronutrient Intake, and Blood Glucose Levels of Informal Electronic Waste Recyclers in Ghana Higher lead levels were associated with higher glucose levels among e-waste recyclers in Ghana. Dawud et al. Int J Environ Res Public Health. Association of environmental exposure to perchlorate, nitrate, and thiocyanate with overweight/obesity and central obesity among children and adolescents in the United States of America using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2016 Thiocyanate exposure was positively associated with overweight/obesity and central obesity in both children and adolescents, perchlorate was negatively associated, and nitrate was not associated. Jiang and Li, New Dir Child Adolesc Dev.

Environmental Chemicals: Laboratory Studies

A microbiome abundant environment remodels the intestinal microbiota and improves resistance to obesity induced by chlorpyrifos in mice Beneficial microbiota protected mice against obesity caused by the pesticide chlorpyrifos. These microbiota modified the intestinal immune system and mitigated intestinal barrier injury. Li et al. Environ Pollut. Air Pollution What is the role of particulate matter 2.5 (PM2.5) on excess weight: A cross-sectional study in young Spanish people aged 2─14 years? The prevalence of excess weight in young people was positively associated with PM2.5 levels in Spain. López-Gil et al. Environ Res. Incense Burning Indoor Pollution: Impact on the prevalence of prediabetes and Type-2 Diabetes Mellitus In Saudi Arabia, the prevalence of pre-diabetes and type 2 diabetes was increased in incense sellers, and further increased with increasing work duration. Al-Khlaiwi et al. Pak J Med Sci. Type 1 Diabetes Elevations in blood glucose before and after the appearance of islet autoantibodies in children. "These findings show heterogeneity in blood glucose control in infancy and early childhood and suggest that islet autoimmunity is concurrent or subsequent to insults on the pancreatic islets." Warncke et al. J Clin Invest. Also see related commentary, Type 1 diabetes: what is the role of autoimmunity in β cell death? "Surprisingly, they found that an elevation in blood glucose preceded the appearance of autoimmunity. This observation calls into question the importance of autoimmunity as the primary cause of β cell destruction." Donath, J Clin Invest.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

I'm trying to include more on type 1, will continue that!

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution

Type 1 Diabetes and Autoimmunity Reviews Hypothesis: Metformin is a potential reproductive toxicant "Metformin in humans is documented to reduce the circulating level of testosterone in both men and women." Tavlo et al. Front Endocrinol. Effects of selenium supplementation on glycaemic control markers in healthy rodents: A systematic review and meta-analysis Selenium supplementation increased fasting blood glucose levels. Ferreira et al. Br J Nutr.

Environmental Chemicals: Human Studies

Association and risk of circulating inflammatory markers with hyperglycemia in coal-burning arsenicosis In a coal-burning area of China, residents with high levels of arsenic exposure had higher fasting blood glucose, risk of hyperglycemia, insulin resistance, and inflammation, and lower beta cell function than people who lived in areas with lower arsenic exposure levels. Liu et al. Ecotoxicol Environ Saf. Trimester two gestational exposure to bisphenol A and adherence to mediterranean diet are associated with adolescent offspring oxidative stress and metabolic syndrome risk in a sex-specific manner Higher exposure to BPA during the second trimester was marginally associated with an increase in oxidative stress in female offspring, and prenatal BPA was associated with a decreased risk of metabolic syndrome in male offspring. Diet also played a role, sometimes in an unexpected way (Mexico City). Zamora et al. Front Nutr. Serum concentrations of phthalate metabolites in pregnant women and their association with gestational diabetes mellitus and blood glucose levels Found significant positive associations between serum concentrations of mono butyl phthalate (MBP) and mono isobutyl phthalate (MiBP) concentrations with both gestational diabetes incidence and 2-hour blood glucose levels (China). Wang et al. Sci Total Environ.

Environmental Chemicals: Laboratory Studies

Effects of legacy and emerging per- and polyfluoroalkyl substances on PPARα/β/γ regulation and osteogenic/adipogenic differentiation PFOS and PFOA decreased bone cell differentiation and enhanced fat cell differentiation of human mesenchymal stem cells, and some replacement chemicals had similar or even stronger effects. Qin et al. Environ Int. Lead exposure exacerbates adverse effects of HFD on metabolic function via disruption of gut microbiome, leading to compromised barrier function and inflammation The metabolic disorders induced by a high-fat diet (HFD) were aggravated by chronic lead intake. Lead injured the colon and disturbed the composition of gut microbiota. Also, fecal microbiota transplantation directly caused metabolic disorders and colonic damage in recipient mice. Hu et al. Eur J Nutr. The influence of perinatal maternal exposure to dibutyl phthalate on glucolipid metabolism in adult female offspring In female offspring rats, perinatal exposure to dibutyl phthalate caused increased weight and visceral adipose tissue and lower triglyceride levels, but no changes to fasting glucose, insulin resistance, fasting insulin, total cholesterol, or adiponectin levels. Zhou et al. Obes Res Clin Pract. Developmental exposure to indoor flame retardants and hypothalamic molecular signatures: Sex-dependent reprogramming of lipid homeostasis In offspring mice, perinatal exposure to environmental levels of a penta-PBDE mixture caused high cholesterol levels, fatty liver, and less brown adipose tissue in females exposed to the lower dose. Kozlova et al. Front Endocrinol (Lausanne). White adipose tissue as a target for cadmium toxicity Low dose chronic cadmium exposure adversely affected fat cell function and fat tissue, with the effects varying by fat depot. Attia et al. Front Pharmacol. Air Pollution Ambient air pollution and hospitalization for type 2 diabetes in China: A nationwide, individual-level case-crossover study Short-term exposure to five air pollutants was associated with a higher risk of hospitalizations for type 2 diabetes, especially type 2 with complications. Luo et al. Environ Res. Is dietary intake of antioxidant vitamins associated with reduced adverse effects of air pollution on diabetes? Findings from a large cohort study Compared with people with insufficient intake of antioxidant vitamins, those with sufficient consumption (especially vitamins C and E) had a weaker association between air pollution (PM2.5, PM10 and NO2) and diabetes (UK). Li et al. Ecotoxicol Environ Saf.

Type 1 Diabetes and Autoimmunity

High incidence of type 1 diabetes, type 2 diabetes and gestational diabetes in Central Iran: A six years results from Semnan health cohort. Type 1 diabetes incidence increased by 12.5% per year from 2015 to 2022; type 2 and gestational diabetes increased even more (15% and 136%). Babakhanian et al. Ann Med Surg (Lond). Dietary fatty acid intake in childhood and the risk of islet autoimmunity and type 1 diabetes: the DIPP birth cohort study Dietary intake of several fatty acids (omega 3, 6, and 9) from infancy through age 6 was associated with a decreased risk of islet autoimmunity or type 1 diabetes by age 15 among high-risk children. Higher intake of total fat and saturated fatty acids was associated with a decreased risk of type 1 diabetes only when adjusted for energy intake. (Finland). Hakola et al. Eur J Nutr. The environmental pollutant 3-methyl-4-nitrophenol reduces the regulatory T cells in the intestine 3-methyl-4-nitrophenol (MNP) reduced the frequency of regulatory T cells (Treg), increased Th17 cells, and converted Tregs to Th17 cells in the intestine in mice. Hu et al. Toxicology. [Tregs help control autoimmunity; intestinal changes like this may be linked to autoimmunity. I don't know anything about this chemical MNP- does anyone? It may be a pesticide precursor or metabolite?].  Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes Gut microbiota from children with new-onset type 1 diabetes increased fasting glucose levels and insulin resistance in antibiotic-treated mice. Yuan et al. Nat Commun.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

new review on type 1 and air pollution! 

plus the evidence that COVID can trigger type 1 diabetes is becoming pretty strong. see this page for more on covid: https://www.diabetesandenvironment.org/home/other-environmental-factors/viruses-and-bacteria

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution Type 1 Diabetes

Reviews Air Pollution, Oxidative Stress, and the Risk of Development of Type 1 Diabetes Reviews literature on air pollution and heavy metals and type 1 diabetes development, with a focus on oxidative stress. Zorena et al. Antioxidants (Basel). Association between Air Pollution and Type 2 Diabetes Mellitus in Developing Countries: A Systematic Review and Meta-Analysis Exposure to PM2.5 was positively associated with an increased prevalence of type 2 diabetes in developing countries. Zi-Han et al. Chin Med Sci J. Pesticides as endocrine disruptors: programming for obesity and diabetes Reviews epidemiological and experimental studies on organochlorine, organophosphate and neonicotinoid pesticide exposure during gestation and lactation and obesity and diabetes in offspring. Miranda et al. Endocrine. Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases Includes discussions of diabetes and obesity. Lima et al. Int J Mol Sci. Added flavors: potential contributors to body weight gain and obesity? Mechanistic studies suggest that added flavors induce overeating and body weight gain; human studies are scarce. Neumann et al. BMC Med.  Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease? Finds that laboratory animals exposed to microplastics and their additives develop inflammation, immunological responses, endocrine disruption, and alterations in lipid and energy metabolism; microplastics are potential obesogens, and could promote NAFLD pathogenesis by modifying gut microbiota composition or worsening liver fibrosis. Auguet et al. Int J Environ Res Public Health.

Environmental Chemicals: Human Studies

Perfluorinated compounds in adults and their association with fasting glucose and incident diabetes: a prospective cohort study In Korean adults, PFOS and PFOA levels at baseline were higher in those who developed diabetes at follow-up. PFOA was associated with a higher risk of developing diabetes. Chung et al. Environ Health. Developing an Exposure Burden Score for Chemical Mixtures Using Item Response Theory, with Applications to PFAS Mixtures "PFAS burden scores and summed PFAS concentrations were both significantly associated with cardio-metabolic outcomes" in the U.S. The authors also present a PFAS burden calculator tool. Liu et al. EHP. Associations of perfluoroalkyl substances with adipocytokines in umbilical cord serum: A mixtures approach PFAS levels were associated with higher adiponectin and lower leptin levels in cord blood, especially in males (China). Ding et al. Environ Res. Lead exposure as a causative factor for metabolic associated fatty liver disease (MAFLD) and a lead exposure related nomogram for MAFLD prevalence Lead exposure was an independent risk factor for metabolically related fatty liver disease (MAFLD), i.e., non-alcoholic fatty liver disease (NAFLD) (U.S. NHANES). Yang et al. Front Public Health.

Environmental Chemicals: Laboratory Studies

Early Life Polychlorinated Biphenyl 126 Exposure Disrupts Gut Microbiota and Metabolic Homeostasis in Mice Fed with High-Fat Diet in Adulthood Early life PCB exposure caused changes to gut microbiota and glucose intolerance in mice. Tian et al. Metabolites. Toxic effects and transcriptional responses in zebrafish liver cells following perfluorooctanoic acid exposure In zebrafish liver cells, PFOA affected gene expression of genes relating to tight junctions, signal transduction, immune system, endocrine system, and metabolism-related pathways. Wu et al. Aquat Toxicol. Estimation of Metabolic Effects upon Cadmium Exposure during Pregnancy Using Tensor Decomposition Determined how prenatal cadmium exposure disrupts insulin metabolism in offspring via oxidative stress. Amakura and Taguchi, Genes (Basel). Air Pollution Ambient air pollution associated with incidence and dynamic progression of type 2 diabetes: a trajectory analysis of a population-based cohort. Using data from the large UK Biobank study, researchers found that air pollution exposure not only increased the risk of developing type 2 diabetes, but also increased the risk of subsequent diabetes complications, and post-diabetes mortality. Wu et al. BMC Med. Associations between the urban exposome and type 2 diabetes: Results from penalised regression by least absolute shrinkage and selection operator and random forest models "Some established risk factors (air pollutants) appeared in univariate analysis but were not among the most important factors in multivariable analysis," while some socioeconomic and demographic factors as well as surface temperature were consistently associated with type 2 diabetes (Netherlands). Ohanyan et al. Environ Int. Type 1 Diabetes Sharp Rise in New-Onset Pediatric Diabetes During the COVID-19 Pandemic. Madison, Wisconsin had a sharp rise in new diabetes diagnoses in children during the pandemic, both type 1 and type 2. Ansar et al. WMJ. Type 1 diabetes recurrence after SARS-CoV-2 infection in a subject with pancreas transplantation A 45-year-old woman with type 1 diabetes was treated with a kidney-pancreas transplantation in 2015, stopped taking insulin, and had good glycaemic control for years. After COVID-19 infection, she developed severe hyperglycemia requiring insulin therapy again, and tested positive for islet cell/GAD autoantibodies. Popolla et al. Endocrinol Diabetes Metab.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

See the final item for a new study on chemicals and type 1!

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution Type 1 Diabetes Reviews

Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease Reviews recent evidence that environmental pollutants inhibit brown adipose tissue function, diet-induced thermogenesis, and the potential signaling pathways mediating these effects. Wang and Steinberg, Curr Opin Pharmacol. Assessing the role of the gut microbiome at the interface between environmental chemical exposures and human health: Current knowledge and challenges Reviews current evidence on environmental pollutants and their effect on the gut microbiome, the metabolic pathways involved, and the long-term effects on health. Campana et al. Environ Pollut. The metabolic conditioning of obesity: A review of the pathogenesis of obesity and the epigenetic pathways that "program" obesity from conception "In this review we argue that how and when such [environmental] exposures come into play from conception significantly impact overall risk of obesity and later health outcomes." The review includes some discussion of chemicals but mostly focuses on other things. Rajamoorthi et al. Front Endocrinol (Lausanne).

Environmental Chemicals: Human Studies

Associations between exposure to brominated flame retardants and metabolic syndrome and its components in U.S. adults Most brominated flame retardants (especially PBB-153, PBDE-28 and PBDE-209) were positively associated with metabolic syndrome overall, specifically with abdominal obesity, hypertriglyceridemia, and low HDL, but not with hypertension or hyperglycemia. Associations were strongest in males. (U.S. NHANES). Che et al. Sci Total Environ. Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies PFOA, PFNA, PFOS, and the PFAS mixture were associated with a lower BMI, and PFHxS was associated with a higher BMI. Schillemans et al. Environ Pollut. Exposure to per- and polyfluoroalkyl substances and glycemic control in older US adults with type 2 diabetes mellitus U.S. adults 65 and older with type 2 diabetes who had higher serum levels of PFNA and PFHxS (both sexes) had higher blood glucose levels (HbA1c), and the same for PFDeA in men. Brosset and Ngueta, Environ Res. Combined effects of prenatal phthalate exposure on cardiometabolic risk score among 4- to 7-year-old children: MABC study Prenatal phthalate mixtures were variously associated with cardiometabolic risk scores in children; some increased risk, some decreased, varying by trimester (China). Gao et al. Chemosphere. Phthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women's Health Across the Nation (SWAN) Multi-Pollutant Study Phthalate metabolites were associated with more rapid body fat gain in midlife U.S. women. Peng et al. Environ Res. Environmental exposure to organophosphate esters and suspected non-alcoholic fatty liver disease among US adults: A mixture analysis Environmental exposure to organophosphorus flame retardants was associated with an elevated risk of NAFLD in males, particularly those over age 60 or with low testosterone levels (U.S. NHANES).Chai et al. Front Public Health.

Environmental Chemicals: Laboratory Studies

BPA exposure in L6 myotubes increased basal glucose metabolism in an estrogen receptor-dependent manner but induced insulin resistance In muscle cells, high concentrations of BPA increase muscle glucose uptake through an estrogen receptor-related mechanism, but induce insulin resistance through another pathway. Kasongo et al. Food Chem Toxicol. Metabolomic, Lipidomic, Transcriptomic, and Metagenomic Analyses in Mice Exposed to PFOS and Fed Soluble and Insoluble Dietary Fibers The soluble fibers inulin and pectin protected mice against PFOS-induced liver metabolic disturbances, fat accumulation in the liver, transcriptional changes, gut microbiota changes, and even the accumulation of PFOS in the body. Deng et al. EHP. Also see related Invited Perspective: PFOS–Pick Fiber, Oust Sulfonate by Golonka and Vijay-Kumar. In vivo hypoglycemic effects of bisphenol F exposure in high-fat diet mice In mice fed a normal diet, BPF did not affect glucose metabolism. But in mice fed a high-fat diet, BPF "improved" glucose metabolism and reduced insulin resistance. Lv et al. Chemosphere. (These authors also found that BPS has similar effects (Guo et al. 2021), but as far as I can tell, other authors have not, although neither BPS nor BPF is particularly well studied in relation to diabetes. One could also argue that "hypoglycemic effects" are not necessarily an "improvement" -- in the case of BPS, the mechanism involved disrupted thyroid signaling). ROS and ERK Pathway Mechanistic Approach on Hepatic Insulin Resistance After Chronic Oral Exposure to Cadmium NOAEL Dose At the (supposed) no observed adverse effect level (NOAEL), cadmium causes insulin resistance in rats. Sarmiento-Ortega et al. Biol Trace Elem Res. Air Pollution Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study In the large UK Biobank study, higher physical activity and lower air pollution levels were both associated with a lower risk of type 2 diabetes. The beneficial effects of physical activity on diabetes generally remained stable among participants exposed to different levels of air pollution. Li et al. Environ Health. Air pollution, road traffic noise and lack of greenness and risk of type 2 diabetes: A multi-exposure prospective study covering Denmark This really large study (everyone over age 50 years living in Denmark in 2005 to 2017) found that air pollution, road traffic noise and lack of green space were all independently associated with higher risk of type 2 diabetes. Sørensen et al. Environ Int. Deficiency of interleukin-6 receptor ameliorates PM2.5 exposure-induced pulmonary dysfunction and inflammation but not abnormalities in glucose homeostasis Lung inflammation plays a role in lung dysfunction caused by particulate matter, but not in liver insulin resistance nor systemic glucose intolerance/ insulin resistance in mice. Peng et al. Ecotoxicol Environ Saf. Association between long-term air pollution exposure and insulin resistance independent of abdominal adiposity in Korean adults The annual mean exposure to PM10 was significantly associated with insulin resistance in both men and women, while NO2, SO2 and CO were not. The association was dose-dependent and was not affected by visceral fatness. Hwang et al. Sci Rep. Chronic Exposure to Fine Particulate Matter Increases Mortality Through Pathways of Metabolic and Cardiovascular Disease: Insights From a Large Mediation Analysis "A significant portion of the estimated effect of long-term exposure to PM2.5 on deaths can be attributed to its effect on diabetes and cardiovascular diseases." (Ontario, Canada). Bai et al. J Am Heart Assoc. Type 1 Diabetes Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice The researchers exposed non-obese diabetic (NOD) mice, an animal model of type 1 diabetes, to a mixture of persistent organic pollutants (including PCBs PBDEs, organochlorines, and PFAS) in the womb and early life. The exposure led to several metabolic changes in the mice-- changes that are linked to an increased risk of type 1 diabetes in humans. Sinioja et al. Metabolomics. [WE NEED MORE STUDIES LIKE THIS!]

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution Type 1 Diabetes Reviews

Role of microRNA in Endocrine Disruptor-Induced Immunomodulation of Metabolic Health Reviews studies that demonstrate the impact of EDCs on innate immunity, and the potential role of microRNAs in metabolic health. Shree et al. Metabolites. Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress Reviews the  mechanisms involved in the developmental programming of metabolic syndrome, focusing on oxidative stress. Includes some discussion of environmental chemicals. Tain and Hsu, Antioxidants (Basel). Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis This review and meta-analysis of 40 million people found that COVID-19 led to an increased risk of diabetes, both type 1 and type 2, in all ages and sexes, and especially within the first three months after diagnosis. Zhang et al. BMC Med.

Environmental Chemicals: Human Studies

Mixtures of Environmental Contaminants and Diabetes Circulating levels of 42 contaminants from several classes were measured at baseline, and incident diabetes followed for 15 years. Nine contaminants (cadmium, lead, mercury, nickel, trans-nonachlor, the phthalate MiBP, PCB-126, PCB-169, and PFOS) improved the model predicting incident diabetes in the first 5 years of follow-up. The single contaminant most closely related to incident diabetes over 5 years was nickel (Sweden). Lind et al. Sci Total Environ. Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study There were positive associations between PFOA and blood glucose, systolic and diastolic blood pressure, total cholesterol and LDL cholesterol; and between PFOS and blood glucose, BMI, waist circumference, systolic blood pressure, total and HDL cholesterol (Czechia). Maranhao Neto et al. Int J Environ Res Public Health. Plasma PFOA and PFOS Levels, DNA Methylation, and Blood Lipid Levels: A Pilot Study Plasma PFOA and PFOS levels were significantly associated with elevated total cholesterol and LDL cholesterol levels, partly mediated by DNA methylation changes in lipid metabolism-related genes (China). Cheng et al. Environ Sci Technol. Association of blood cadmium and metabolic syndrome: a cross-sectional analysis of National Health and Nutrition Examination Survey 2017-2020 People with metabolic syndrome had higher cadmium levels, as did those with a higher waist circumference, triglycerides, blood pressure, and fasting glucose levels (U.S.). Xing et al. Environ Sci Pollut Res Int. Exposure to Metal Mixtures and Overweight or Obesity Among Chinese Adults Zinc was positively associated with metabolic unhealthy overweight/obesity, while arsenic, cadmium, nickel, and strontium (and the metal mixture) were negatively associated. Fan et al. Biol Trace Elem Res. [Note that this study separated out metabolic healthy vs unhealthy overweight/obesity.]

Environmental Chemicals: Laboratory Studies

The p-Phthalates Terephthalic Acid and Dimethyl Terephthalate Used in the Manufacture of PET Induce In Vitro Adipocytes Dysfunction by Altering Adipogenesis and Thermogenesis Mechanisms Environmentally relevant levels of these phthalates affected fat cell differentiation. Molonia et al. Molecules. Effect of Phorate on the Development of Hyperglycaemia in Mouse and Resistance Genes in Intestinal Microbiota Both low and high doses of the insecticide phorate caused high blood glucose in mice fed a high-fat diet, and also affected gut microbiota Cao et al. Antibiotics (Basel). Low-Dose Dioxin Reduced Glucose Uptake in C2C12 Myocytes: The Role of Mitochondrial Oxidative Stress and Insulin-Dependent Calcium Mobilization Low-dose TCDD induced muscle insulin resistance, independent of AhR. Im et al. Antioxidants (Basel). Triclocarban and triclosan exacerbate high-fat diet-induced hepatic lipid accumulation at environmental related levels: The potential roles of estrogen-related receptors pathways Triclocarban had little influence on hepatic lipid accumulation in mice fed a normal diet, but exacerbated lipid accumulation in mice fed a high-fat diet. Li et al. Sci Total Environ. Hexafluoropropylene oxide trimer acid (HFPO-TA) disturbs embryonic liver and biliary system development in zebrafish Hexafluoropropylene oxide trimer acid, an alternative to perfluorooctanoic acid (PFOA), decreased total cholesterol and triglyceride activities, disturbed lipid metabolism, and induced inflammation, among other things. Sun et al. Sci Total Environ. Preconception exposure to malathion and glucose homeostasis in rats: Effects on dams during pregnancy and post-term periods, and on their progeny In rats, exposure to environmentally relevant levels of the pesticide malathion *before conception* caused glucose intolerance in mothers during and after pregnancy, as well as increased visceral adipose tissue mass, dyslipidemia, varying insulin responses to glucose, but unchanged pancreatic β-cell mass. The offspring, as adults, were also glucose intolerant. Bruxel et al. Environ Pollut. Short-term trivalent arsenic and hexavalent chromium exposures induce gut dysbiosis and transcriptional alteration in adipose tissue of mice Inorganic arsenic and hexavalent chromium exposure reduced beneficial gut bacteria and increased harmful gut bacteria, impaired gut barrier strucure, enhanced adipogenesis and reduced thermogenesis in brown adipose tissue, and caused inflammation. Singh et al. Mol Biol Rep.  Air Pollution Association of Short-Term Exposure to PM2.5 with Blood Lipids and the Modification Effects of Insulin Resistance: A Panel Study in Wuhan Short-term PM2.5 exposure among healthy adults was associated with reduced triglyceride, total cholesterol, and LDL cholesterol levels, and elevated HDL cholesterol. These associations were modulated by insulin resistance. Sun et al. Toxics. Long-term Exposure to Ambient PM2.5 and Its Components Associated With Diabetes: Evidence From a Large Population-Based Cohort From China Long-term exposure to particulate mater and its components (black carbon, nitrate, ammonium, organic matter, and soil particles) was positively associated with diabetes development, especially in those over age 65. Li et al. Diabetes Care. Association of household air pollution with glucose homeostasis markers in Chinese rural women: Effect modification of socioeconomic status Cooking with solid fuel was associated with decreased insulin levels in women, especially those with low incomes. Kang et al. Ecotoxicol Environ Saf. Type 1 Diabetes Estimating the total incidence of type 1 diabetes in children and adolescents aged 0-19 years from 1990 to 2050: a global simulation-based analysis Estimates that in 2021 there were 355,900 total new cases of type 1 diabetes globally among children and adolescents, of which 56% were diagnosed. This number is projected to increase to 476,700 in 2050. Ward et al. Lancet Diabetes Endocrinol. See related, Trending now: modelling global epidemiology of type 1 diabetes in children and adolescents (Stene and Haynes, Lancet Diabetes Endocrinol.).

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

Early this week due to the holiday, Happy Thanksgiving!

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution

Reviews Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence Reviews clinical and mechanistic evidence that EDCs can contribute to the development of obesity and diabetes. Kurşunoğlu and Sarer Yurekli, World J Clin Cases. The Pediatrician's Role in Protecting Children from Environmental Hazards "Although metals and air pollutants are the focus of environmental health training in medical school and residency, endocrine disrupting chemicals have emerged as major drivers of disease and disability." Trasande and Kassotis, Pediatr Clin North Am.

Environmental Chemicals: Human Studies

Sex-specific associations of the urinary fourteen-metal mixture with NAFLD and liver fibrosis among US adults: A nationally representative study A metal mixture was associated with a biomarker of non-alcoholic liver disease (NAFLD) in women (not men, and not with a biomarker of liver fibrosis). Wan et al. Ecotoxicol Environ Saf. Environmental Chemicals: Laboratory Studies Consequences of in vitro benzyl butyl phthalate exposure for blubber gene expression and insulin-induced Akt activation in juvenile grey seals The data suggest phthalate exposure could alter seal blubber development or function. Tranganida et al. Environ Pollut. Air Pollution Long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus - A cohort study in northern Sweden Increased incidence of diabetes was associated with higher exposure to PM10, PM10 trom traffic, and PM2.5 from exhaust. Sommar et al. Environ Res. Maternal Exposure to Fine Particulate Matter and Its Chemical Components Increasing the Occurrence of Gestational Diabetes Mellitus in Pregnant Japanese Women Found an association between gestational diabetes and PM2.5 exposure during the first trimester, but not for the 3 months before pregnancy or the second trimester. For PM2.5 components, only organic carbon exposure during the first trimester was associated. Michikawa et al. JMA J.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution

Environmental Chemicals: Human Studies Chemical mixture exposure patterns and obesity among U.S. adults in NHANES 2005-2012 Patterns of high levels of mono-ethyl phthalate (MEP), high levels of naphthalene metabolites, and a pattern of high exposure levels of other phthalates (MCOP, MCNP, and MCPP) were positively associated with obesity. Zhang et al. Ecotoxicol Environ Saf. Associations between Prenatal Exposure to Phthalates and Features of the Metabolic Syndrome in Males from Childhood into Adulthood Higher prenatal exposure to some phthalate metabolites was associated with some adverse metabolic profiles through adolescence into adulthood, although the consistent associations only included a few metabolites and the outcomes of systolic blood pressure, fasting insulin, and glucose (Australia). Berman et al. Int J Environ Res Public Health. Is the cholesterol-perfluoroalkyl substance association confounded by dietary fiber intake?: a Bayesian analysis of NHANES data with adjustment for measurement error in fiber intake The association of serum cholesterol with PFAS was not confounded by fiber intake (U.S.). Linakis et al. Environ Health.

Environmental Chemicals: Laboratory Studies

In vitro biochemical assessment of mixture effects of two endocrine disruptors on INS-1 cells The toxic effects of triclosan and a mixture of triclosan and 4-tert-octylphenol on insulin secreting cells was due to effects on the mitochondria. Olaniyan and Okoh, Sci Rep. Perfluorodecanoic acid promotes adipogenesis via NLRP3 inflammasome-mediated pathway in HepG2 and 3T3-L1 cells PFDA, a PFAS chemical used in food packaging, increased triglyceride accumulation and inflammation in liver and fat cells. Wang et al. Food Chem Toxicol. BDE-47, -99, -209 and Their Ternary Mixture Disrupt Glucose and Lipid Metabolism of Hepg2 Cells at Dietary Relevant Concentrations: Mechanistic Insight through Integrated Transcriptomics and Proteomics Analysis At low levels, these PBDE flame retardants, individually and in a mixture, affected glucose and lipid metabolism with different underlying modes of action. Casella et al. Int J Mol Sci. Air Pollution Association of long-term exposure to PM2.5 constituents with glucose metabolism in Chinese rural population PM2.5 and its constituents were associated with type 2 diabetes, increased fasting blood glucose, and decreased insulin and beta cell function; black carbon was the constituent most responsible for these associations. Kang et al. Sci Total Environ. Association of PM2.5 and Its Chemical Compositions with Metabolic Syndrome: A Nationwide Study in Middle-Aged and Older Chinese Adults Higher exposure to fine particulate matter was associated with an increased risk of metabolic syndrome, and again, black carbon was the most responsible constituent. Guo et al. Int J Environ Res Public Health. Prenatal ozone exposure programs a sexually dimorphic susceptibility to high-fat diet in adolescent Long Evans rats Maternal ozone exposure in early pregnancy caused male and female offspring to be heavier, eat more, and have a lower metabolic rate when fed a high-fat diet than offspring exposed to filtered air. Male offspring had dyslipidemia and increased adiposity, while female offspring had liver dysfunction. Stewart et al. FASEB J. Sex-Dependent Responses to Maternal Exposure to PM2.5 in the Offspring Mice were exposed to low levels of particulate matter before/during/after pregnancy, or just until conception. Female offspring in both groups had increased liver triglyceride and glycogen levels, glucose intolerance, but reduced serum insulin and insulin resistance. Male offspring from only the before-conception group had increased liver and serum triglycerides, increased liver glycogen, glucose intolerance and higher fasting glucose levels. In sum, moving mice from a polluted to clean environment during gestation did not prevent all the problems caused by air pollution exposure before conception. Chen et al. Antioxidants (Basel).

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews

Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies Air Pollution

Reviews Nutritional, pharmacological, and environmental programming of NAFLD in early life Reviews some the maternal and paternal conditions that may be involved in early-life programing of non-alcoholic fatty liver disease (NAFLD), including some discussion of environmental chemicals. Galvan-Martinez et al. Am J Physiol Gastrointest Liver Physiol. Genetics, epigenetics and transgenerational transmission of obesity in children Reviews the contribution of heritable genetic and epigenetic patterns to obesity susceptibility in children, with a particular emphasis on the mother-child dyad; includes some discussion of endocrine disruptors. Panera et al. Front Endocrinol (Lausanne).

Environmental Chemicals: Human Studies

Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption? A year after bariatric surgery, there were significant increases in POP levels, as well as an increase in adiponectin and a decrease in leptin levels. There were highly significant associations between adiponectin and all the POPs, especially HCB (Norway). Jansen et al. Chemosphere. Association between combined exposure to plasma heavy metals and dyslipidemia in a Chinese population Arsenic was positively associated with dyslipidemia, and females with low plasma zinc levels were more likely to develop dyslipidemia. Luo et al. Lipids Health Dis. Associations of Prenatal First Trimester Essential and Nonessential Metal Mixtures with Body Size and Adiposity in Childhood Higher prenatal levels of a mixture of non-essential metals (arsenic, barium, cadmium, cesium, lead, and mercury) was associated with higher adiposity (total and trunk fat mass index, waist circumference, and BMI in mid-childhood, and total fat mass index and BMI in early adolescence), while prenatal levels of essential metals (magnesium, manganese, selenium, and zinc) were associated with lower adiposity (U.S.). Smith et al. Epidemiology.

Environmental Chemicals: Laboratory Studies

Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos Tris(4-chlorophenyl) methane (TCPM) and tris(4-chlorophenyl)methanol (TCPMOH) are manufacturing byproducts of DDT. Islet and total pancreas area were reduced in embryos exposed to TCPMOH, but not TCPM. Wilson et al. Birth Defects Res.  Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of BPA-induced obesity Exposure of pregnant mice to BPA results in obesity in the F2 progeny due to increased food intake, and is transmitted up to the F6 generation. Deleting a certain site in a certain gene prevents these effects. Jung et al. Proc Natl Acad Sci USA. Integrated miRNA-mRNA analysis reveals the dysregulation of lipid metabolism in mouse liver induced by developmental arsenic exposure In mice, developmental exposure to arsenic caused changes linked to non-alcoholic fatty liver disease (NAFLD). Chen et al. J Hazard Mater. PFAS-induced lipidomic dysregulations and their associations with developmental toxicity in zebrafish embryos PFOS and PFOA affected lipid metabolism in zebrafish embryos, and DHA supplements did not correct the problems. Yang et al. Sci Total Environ. Environmental concentrations of benzophenone-3 disturbed lipid metabolism in the liver of clown anemonefish (Amphiprion ocellaris) The UV filter benzophenone-3 disturbed liver lipid metabolism of clown anemonefish. Zhang et al. Environ Pollut. Air Pollution Association of urinary and ambient black carbon, and other ambient pollutants with risk of prediabetes and metabolic syndrome in children and adolescents An association between ambient black carbon and metabolic syndrome was only seen in children living close to a major road (Eight European countries). Nagrani et al. Environ Pollut. Early pregnancy particulate matter exposure, pre-pregnancy adiposity and risk of gestational diabetes mellitus in Finnish primiparous women: An observational cohort study Low PM10 exposure level together with elevated maternal pre-pregnancy BMI was associated with an increased risk of gestational diabetes (Finland). Laine et al. Prim Care Diabetes.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Reviews Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies

Reviews Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review Concludes that exposure to BPS or BPF may promote the development of obesity and diabetes, and that BPS may promote worse obesogenic effects than BPA. Alharbi et al. Int J Environ Res Public Health. Impact of Paraben Exposure on Adiposity-Related Measures: An Updated Literature Review of Population-Based Studies Overall, evidence suggests that exposure to parabens, especially during development, is associated with weight-related measures, although there are some limitations to the studies. Xu et al. Int J Environ Res Public Health.

Environmental Chemicals: Human Studies

Effects of exposure to phthalate during early pregnancy on gestational diabetes mellitus: a nested case-control study with propensity score matching Urinary concentrations of numerous phthalate metabolites were associated with an increased risk of developing gestational diabetes (rural China). Chen et al. Environ Sci Pollut Res Int. Human serum poly- and perfluoroalkyl substance concentrations and their associations with gestational diabetes mellitus Higher exposure levels to numerous PFAS (PFOA, PFNA, PFHxS, and 6:2 Cl-PFESA) were associated with a higher risk of gestational diabetes (China). Zhang et al. Environ Pollut. The association of phthalate metabolites with childhood waist circumference and abdominal obesity In Chinese children age 7-10, levels of monoethyl phthalate and monoisobutyl phthalate were associated with a large increased risk of abdominal obesity. Wang et al. Eur J Pediatr. Gestational exposure to organophosphate esters and adiposity measures of children up to 6 years: Effect modification by breastfeeding Prenatal exposure to numerous organophosphate flame retardants was associated with higher weight-related measures in children at age 6 who were breastfed for 4 months or less, but not among those breastfed for more than 4 months (China). Chen et al. Int J Hyg Environ Health. Associations of phthalates with NAFLD and liver fibrosis: A nationally representative cross-sectional study from NHANES 2017 to 2018 In U.S. adults, a higher prevalence of non-alcoholic fatty liver disease (NAFLD) was associated with DEHP but not DINP or DIDP exposure. Chen et al. Front Nutr. Human serum lipidomics analysis revealed glyphosate may lead to lipid metabolism disorders and health risks Potential health risks from the pesticide glyphosate include chronic liver and kidney dysfunction, atherosclerosis, cardiovascular disease and neurodegenerative diseases (China). Zhang et al. Environ Int. Urinary metal profiles in mother-offspring pairs and their association with early dysglycemia in the International Hyperglycemia and Adverse Pregnancy Outcome Follow Up Study (HAPO-FUS) This international study found that urinary levels of zinc, selenium, arsenic, and cadmium showed varying degrees of association with early dysglycemia in a comparatively healthy cohort with a low rate of preexisting diabetes. El Muayed et al. J Expo Sci Environ Epidemiol.

Environmental Chemicals: Laboratory Studies

Benzophenones alter autophagy and ER stress gene expression in pancreatic beta cells in vitro Benzophenones, used in sunscreens and food packaging, affected cellular processes in mouse pancreatic beta cells, indicating that exposure could lead to beta cell dysfunction. Szulak et al. In Vitro Cell Dev Biol Anim. Perfluorooctanoic Acid-Disturbed Serum and Liver Lipidome in C57BL/6 Mice Both high and low levels of PFOA disturbed lipid profiles in serum and liver, e.g. increasing triglyceride levels, with greater impacts in the liver than the serum. Gao et al. Chem Res Toxicol. Tris(1,3-dichloro-2-propyl) phosphate is a metabolism-disrupting chemical in male mice In male mice, the flame retardant TDCPP caused adiposity, fasting hyperglycemia, and insulin resistance. Tenlep et al. Toxicol Lett. Dibutyl phthalate affects insulin synthesis and secretion by regulating the mitochondrial apoptotic pathway and oxidative stress in rat insulinoma cells Dibutyl phthalate induced cell death and dysfunctional in insulin secreting cells through mechanisms involving oxidative stress. Yang et al. Ecotoxicol Environ Saf. Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics In rats, developmental exposure to a high-fat diet and the pesticide chlorpyrifos plus a high-fat diet induced a dysfunctional metabolism and an imbalance in the gut flora in both dams and the female offspring. The prebiotic inulin reduced the impact of exposure to a high-fat diet but not to chlorpyrifos plus a high-fat diet. Djekkoun et al. Eur J Nutr. New insight on the mechanism of eating disorder in females based on metabolic differences of bisphenol S in female and male zebrafish Adult female zebrafish treated with BPS had overeating, a decrease of serotonin in the gut, hypoglycemia and hyperlipidemia. Li et al. Environ Pollut.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book

Want to change how you receive these emails? You can update your preferences or unsubscribe from this list

[Sarah Howard]

---------- Forwarded message ---------

View this email in your browser CHE Diabetes and Obesity News and Updates

Environmental Chemicals: Human Studies Environmental Chemicals: Laboratory Studies

Air Pollution   Happy Holidays everyone! No issue next week, see you in January!

Environmental Chemicals: Human Studies

Associations of early life phthalate exposures with adolescent lipid levels and insulin resistance: The HOME Study While most associations were weak or null, early life levels of MEP, MiBP, and MnBP were associated with lower LDL and HDL cholesterol levels at age 12 years, with lower LDL levels seen in females but not males. Some phthalate concentrations were cross-sectionally associated with insulin resistance (Cincinnati HOME study). Etzel et al. Int J Hyg Environ Health. Relationships Between Indicators of Metabolic Disorders and Selected Concentrations of Bioelements and Lead in Serum and Bone Tissue in Aging Men Bone and blood were obtained from people undergoing hip replacement surgery. Lead was not associated with metabolic parameters (Poland). Rył et al. Diabetes Metab Syndr Obes. Perfluoroalkyl Substance Serum Concentrations and Cholesterol Absorption-Inhibiting Medication Ezetimibe The medication ezetimibe, which inhibits cholesterol absorption, does not affect serum PFAS concentrations in people in the C8 study (U.S.). Ma and Ducatman, Toxics.

Environmental Chemicals: Laboratory Studies

Polyhalogenated carbazoles induce hepatic metabolic disorders in mice via alteration in gut microbiota The emerging contaminants polyhalogenated carbazoles affected glucose levels, gut microbiota, and the liver in mice. Ji et al. J Environ Sci. Lambda-cyhalothrin induces lipid accumulation in mouse liver is associated with AMPK inactivation This pyrethroid insecticide induced obesity, dyslipidemia and liver steatosis in mice. Yang et al. Food Chem Toxicol.  2,3,7,8-Tetrachlorodibenzo-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway In mice, 3 weeks of dioxin exposure caused fat accumulation in liver cells, among other things. Cong et al. Toxicol Sci. Air Pollution The relationship between hair metabolites, air pollution exposure and gestational diabetes mellitus: A longitudinal study from pre-conception to third trimester The maternal hair metabolome reflected the longitudinal metabolic changes that occur in response to air pollution exposures and the development of gestational diabetes (China). Chen et al. Front Endocrinol (Lausanne). The modifiable effect of vitamin D in the association between long-term exposure to ambient air pollution and glycosylated hemoglobin in patients with hypertension In people with hypertension, higher long-term air pollutant exposures were associated with higher HbA1c levels (a measure of long-term blood glucose) in a dose-response fashion, especially in people with low vitamin D levels (UK Biobank study). Wang et al. Nutrition.

To see how these studies relate to existing research, or for more on environmental chemicals and diabetes/obesity, visit www.diabetesandenvironment.org

Collaborative on Health and the Environment in...@healthandenvironment.org | www.healthandenvironment.org

Copyright © 2022 Collaborative on Health and the Environment, All rights reserved. You are receiving this email because you opted in to the Diabetes Obesity Scienceserv Our mailing address is: Collaborative on Health and the Environment PO Box 316 Bolinas, CA 94924 Add us to your address book