Week of Feb. 24 - Mar. 2, 2023
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Environmental Chemicals: Human Studies
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Environmental Chemicals: Laboratory Studies
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Oral Exposure to Polystyrene Microplastics of Mice on a Normal or High-Fat Diet and Intestinal and Metabolic Outcomes.
Polystyrene microplastics increased gut inflammation, blood glucose, lipid levels, and signs of non-alcoholic fatty liver disease (NAFLD), but only in mice fed a high-fat diet. Okamura et al. Environ Health Perspect.
Alteration of hepato-lipidomic homeostasis in A/J mice fed an environmentally relevant PFAS mixture.
A mixture of PFAS at levels found in the environment (in earthworms at a ski area!) led to higher body weight, plus oxidative stress and other detrimental effects in the liver of mice. Khan et al. Environ Int.
Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling.
This emerging PFAS increased lipid accumulation in liver cells, and the authors identified a marker/key event that could be used as a toxicity maker for risk assessment. Li et al. Environ Int.
Preliminary Study on the Protective Effects and Molecular Mechanism of Procyanidins against PFOS-Induced Glucose-Stimulated Insulin Secretion Impairment in INS-1 Cells.
PFOS reduced insulin secretion from INS-1 cells, and the flavonoids procyanidins reduced this and other effects. Xu et al. Toxics.
Effects of 2-ethylhexyl diphenyl phosphate exposure on the glucolipid metabolism and cardiac developmental toxicity in larval zebrafish based on transcriptomic analysis.
2-Ethylhexyl diphenyl phosphate (EHDPP), an organophosphorus flame retardant used for making PVC, affected glucose and triglyceride levels in zebrafish larvae. Xu et al. Comp Biochem Physiol C Toxicol Pharmacol.
Liquid Crystal Monomer: A Potential PPARγ Antagonist.
Certain liquid crystal monomers antagonized peroxisome proliferator-activated receptor gamma (PPARγ), which is involved in obesity. Zhao et al. Environ Sci Technol.
Structural basis of the activation of PPARγ by the plasticizer metabolites MEHP and MINCH.
Describes how the metabolites of the plasticizer DEHP and its replacement DINCH bind to PPARγ, which is involved in obesity. Useini et al. Environ Int.
Long-term exposure to low-dose Di(2-ethylhexyl) phthalate aggravated high fat diet-induced obesity in female mice.
Low dose DEHP increased fat accumulation both in control and high-fat diet fed mice, and accelerated weight gain without affecting food intake in high-fat diet fed mice. Zhang et al. Ecotoxicol Environ Saf.
A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation.
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