Fwd: Research Roundup

[Sarah Howard]

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Sarah

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View this email in your browser Week of Mar. 17-23, 2023 Reviews Association Between Non-alcoholic Fatty Liver Disease and Heavy Metal Exposure: a Systematic Review. Found a positive association between arsenic, cadmium, iron, lead, mercury, and NAFLD, and a negative association with zinc and copper. Sadighara et al. Biol Trace Elem Res. Ambient air pollution and gestational diabetes mellitus: An updated systematic review and meta-analysis. This meta-analysis of 31 studies found that exposure to PM2.5, PM10, SO2, and NO2 was associated with an increased risk of gestational diabetes, especially when exposure occurs in preconception and the first trimester, and that the composition of the particulates (especially black carbon and nitrates) is more important than the concentration. Liang et al. Ecotoxicol Environ Saf. Environmental Chemicals: Human Studies Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study. Maternal nutritional status may modulate the effect of prenatal exposure to POPs on childhood overweight/obesity (Spain). Cano-Sancho et al. EHP. See related: Invited Perspective: Can Eating a Healthy Diet during Pregnancy Attenuate the Obesogenic Effects of Persistent Organic Pollutants? Jaacks, EHP. Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, pesticides, and diabetes in the Anniston Community Health Survey follow-up (ACHS II). In people living in Anniston, Alabama (near a PCB manufacturing plant), exposure to PCBs, PCDDs, trans-nonachlor and DDE were associated with an increased risk of type 2 diabetes. Pavuk et al. Sci Total Environ. Individual and mixtures of polychlorinated biphenyls and organochlorine pesticides exposure in relation to metabolic syndrome among Chinese adults. Higher exposure to β-HCH, DDE, and PCBs, as well as their mixtures, were correlated with an increased risk of metabolic syndrome. Zhang et al. Sci Total Environ. Environmental Chemicals: Laboratory Studies Bisphenol F induced hyperglycemia via activation of oxidative stress-responsive miR-200 family in the pancreas. Mice were exposed to four bisphenols. BPA and BPS caused higher insulin levels, while BPF caused lower insulin and higher blood glucose levels. Liu et al. Ecotoxicol Environ Saf. Effect of probiotics on glucose levels and weight gain in mice exposed to low doses of malathion. The insecticide malathion caused increased weight and higher glucose levels in mice, and probiotics reduced these effects. Simoni-Berra et al. Gac Med Mex. A new strategy to alleviate the obesity induced by endocrine disruptors-A unique lysine metabolic pathway of nanoselenium Siraitia grosvenorii to repair gut microbiota and resist obesity. This compound improves gut microbiota and inhibits obesity in mice. Wang et al. Food Chem Toxicol. Air Pollution Maternal 25(OH)D attenuates the relationship between ambient air pollution during pregnancy and fetal hyperinsulinism. Higher air pollution exposure during pregnancy was associated with higher c-peptide (higher insulin production) and inflammation in umbilical cord blood, and higher maternal vitamin D levels reduced the effects (China). Wang et al. Chemosphere. Effects of short-term PM2.5 exposure on blood lipids among 197,957 people in eastern China. PM2.5 exposure was associated with higher LDL and total cholesterol levels, and with lower triglyceride levels. Liu et al. Sci Rep. Fine particulate matter (PM2.5)-induced pulmonary oxidative stress contributes to increases in glucose intolerance and insulin resistance in a mouse model of circadian dyssynchrony. Mice that experienced circadian rhythm disruption were more susceptible to the diabetes-related effects of air pollution (glucose intolerance and insulin resistance). Ribble et al. Sci Total Environ. Type 1 Diabetes and Autoimmunity Increased levels of IL-17 and autoantibodies following Bisphenol A exposure were associated with activation of PI3K/AKT/mTOR pathway and abnormal autophagy in MRL/lpr mice. In mice, BPA induced the development of the autoimmune disease lupus, and mice with lupus were more susceptible to the effects of BPA. Dong et al. Ecotoxicol Environ Saf. Donate to HEEDS We appreciate any and all donations! Your support helps make all our work possible. HEEDS is a program of Environmental Health Sciences. Thank you! Donate here Healthy Environment and Endocrine Disruptor Strategies HEEDS.org In...@heeds.org Copyright © 2023 Environmental Health Sciences, All rights reserved. Our mailing address is: Environmental Health Sciences, 614 W. Lamme St., Bozeman, Montana 59715, United States