Our middle relievers like Hurter, Anderson, DeJesus, Hanifee, (and maybe Madden) will need to step it up. They'll be getting a lot of work in the non-Valdez/Mize/Montero starts.
When Melton comes back in a few weeks (we hope), he'll probably be a reliever at first.
Jobe probably won't be back until September, or maybe not at all. I wouldn't count on him.
We have some depth to survive without Skubal until August. You never know, maybe the team will rally together and play some inspired baseball. I don't think anyone is going to run away with the AL Central so we should still be in contention when Skubal comes
back (but we can't really afford many more injuries to key players).
Peter