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The Origins Space Telescope will trace the history of our origins from the time dust and heavy elements permanently altered the cosmic landscape to present-day life. How did galaxies evolve from the earliest galactic systems to those found in the universe today? How do habitable planets form? How common are life-bearing worlds? To answer these alluring questions, Origins will operate at mid- and far-infrared wavelengths and offer powerful spectroscopic instruments and sensitivity three orders of magnitude better than that of Herschel, the largest telescope flown in space to date.
Meet your closest ancestors and relatives in this interactive exploration of human evolution. This 15,000-square-foot gallery invites you to explore the scientific evidence of human origins over the past 6 million years and traces how we evolved the unique traits that distinguish our species.
Origins helps you develop a deeper understanding of the origins of the universe and sort out your own views on faith and science. Small group discussion questions follow each chapter. A companion website provides resources for further study.
"Messiah College pioneered the multiple models approach to teaching Christian students about origins, and this is the book we are now using very successfully in the most popular course on our campus. The Haarsmas approach this very controversial topic with a perfect mix of scientifically and biblically accurate information, theological depth, intellectual modesty, and a charitable spirit toward views they do not share themselves. Pastors, laypeople, and scientists will all find much to value here."
Edward B Davis, PhD
Distinguished Professor of the History of Science
Messiah College
"Origins, Revised presents a perspective on origins of the universe, the earth, life on earth, and of humans that is faithful to the Bible and to science. In an easy to understand style of writing, the Haarsmas' provide a valuable resource for schools, churches, and anyone interested in origins."
Randall D Isaac
Executive Director
American Scientific Affiliation
An origin refers to the application deployment that Azure Front Door retrieves contents from when caching isn't enabled or when a cache gets missed. Azure Front Door supports origins hosted in Azure and applications hosted in your on-premises datacenter or with another cloud provider. An origin shouldn't be confused with your database tier or storage tier. The origin should be viewed as the endpoint for your application backend. When you add an origin to an origin group in the Front Door configuration, you must also configure the following settings:
An origin group in Azure Front Door refers to a set of origins that receives similar traffic for their application. You can define the origin group as a logical grouping of your application instances across the world that receives the same traffic and responds with an expected behavior. These origins can be deployed across different regions or within the same region. All origins can be deployed in an Active/Active or Active/Passive configuration.
Azure Front Door sends periodic HTTP/HTTPS probe requests to each of your configured origins. Probe requests determine the proximity and health of each origin to load balance your end-user requests. Health probe settings for an origin group define how we poll the health status of app backends. The following settings are available for load-balancing configuration:
Path: The URL used for probe requests for all the origins in the origin group. For example, if one of your origins is contoso-westus.azurewebsites.net and the path gets set to /probe/test.aspx, then Front Door sends health probe requests to -westus.azurewebsites.net/probe/test.aspx if the protocol is set to HTTP.
Load-balancing settings for the origin group define how we evaluate health probes. These settings determine if the origin is healthy or unhealthy. They also check how to load-balance traffic between different origins in the origin group. The following settings are available for load-balancing configuration:
The Governments of Australia, Canada, Czechia, Denmark, Estonia, Israel, Japan, Latvia, Lithuania, Norway, the Republic of Korea, Slovenia, the United Kingdom, and the United States of America remain steadfast in our commitment to working with the World Health Organization (WHO), international experts who have a vital mission, and the global community to understand the origins of this pandemic in order to improve our collective global health security and response. Together, we support a transparent and independent analysis and evaluation, free from interference and undue influence, of the origins of the COVID-19 pandemic. In this regard, we join in expressing shared concerns regarding the recent WHO-convened study in China, while at the same time reinforcing the importance of working together toward the development and use of a swift, effective, transparent, science-based, and independent process for international evaluations of such outbreaks of unknown origin in the future.
The mission of the WHO is critical to advancing global health and health security, and we fully support its experts and staff and recognize their tireless work to bring an end to the COVID-19 pandemic, including understanding how the pandemic started and spread. With such an important mandate, it is equally essential that we voice our shared concerns that the international expert study on the source of the SARS-CoV-2 virus was significantly delayed and lacked access to complete, original data and samples. Scientific missions like these should be able to do their work under conditions that produce independent and objective recommendations and findings. We share these concerns not only for the benefit of learning all we can about the origins of this pandemic, but also to lay a pathway to a timely, transparent, evidence-based process for the next phase of this study as well as for the next health crises.
We note the findings and recommendations, including the need for further studies of animals to find the means of introduction into humans, and urge momentum for expert-driven phase 2 studies. Going forward, there must now be a renewed commitment by WHO and all Member States to access, transparency, and timeliness. In a serious outbreak of an unknown pathogen with pandemic potential, a rapid, independent, expert-led, and unimpeded evaluation of the origins is critical to better prepare our people, our public health institutions, our industries, and our governments to respond successfully to such an outbreak and prevent future pandemics. It is critical for independent experts to have full access to all pertinent human, animal, and environmental data, research, and personnel involved in the early stages of the outbreak relevant to determining how this pandemic emerged. With all data in hand, the international community may independently assess COVID-19 origins, learn valuable lessons from this pandemic, and prevent future devastating consequences from outbreaks of disease.
The Simons Collaboration on the Origins of Life aimed to advance our understanding of the processes that led to the emergence of life through collaborative, multidisciplinary research. The collaboration comprised investigators and postdoctoral fellows in diverse fields, whose research addressed critical questions regarding origins.
The Center for the Study of Origins (CSO) fosters interdisciplinary investigations into specific topics on origins and transdisciplinary research into the general nature (structure, justification, and function) of theories of origins, including ways in which they are used to understand the present and envision the future.
A Celebration of Food and Origins in their infinite diversity!Join Us for this unique "North Star" experience!How has FOOD played a role in your cultural, family, and/or personal origins?What story can a recipe tell you about your life?Can you have a mouthful of culture? A cupful of history? A...
A tentative earlier formulation1 noted that major infectious diseases of temperate zones seem to have arisen overwhelmingly in the Old World (Africa, Asia and Europe), often from diseases of Old World domestic animals. Hence one goal of this article is to re-appraise that conclusion in the light of studies of the past decade. Another goal is to extend the analysis to origins of tropical diseases3. We shall show that they also arose mainly in the Old World, but for different reasons, and mostly not from diseases of domestic animals.
We begin by defining five stages in the evolutionary transformation of an animal pathogen into a specialized pathogen of humans, and by considering why so many pathogens fail to make the transition from one stage to the next. We then assemble a database of 15 temperate and 10 tropical diseases of high evolutionary and/or historical impact, and we compare their characteristics and origins. Our concluding section lays out some unresolved questions and suggests two expanded research priorities. We restrict our discussion to unicellular microbial pathogens. We exclude macroparasites (in the sense of ref. 7), as well as normally benign commensals that cause serious illness only in weakened hosts. The extensive Supplementary Information provides details and references on our 25 diseases, robustness tests of our conclusions, factors affecting transitions between disease stages, and modern practices altering the risk of emergence of new diseases.
It is interesting that fewer tropical than temperate pathogens originated from domestic animals: not more than three of the ten tropical diseases of Supplementary Table S1, and possibly none (see Supplementary Note S7). Why do temperate and tropical human diseases differ so markedly in their animal origins? Many (4/10) tropical diseases (AIDS, dengue fever, vivax malaria, yellow fever) but only 1/15 temperate diseases (hepatitis B) have wild non-human primate origins (P = 0.04). This is because although non-human primates are the animals most closely related to humans and hence pose the weakest species barriers to pathogen transfer, the vast majority of primate species is tropical rather than temperate. Conversely, few tropical but many temperate diseases arose from domestic animals, and this is because domestic animals live mainly in the temperate zones, and their concentration there was formerly even more lop-sided (see Supplementary Note S8).
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