For computeMatrix you'll need to select multiple samples in the "Score file" field. Then they'll appear as adjacent panels in the same plot when you use plotProfile. If you want them in the same panel then in plotProfile set "Show advanced options" to "Yes" and toggle "Make one plot per group of regions" to "Yes".
Devon
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-- Devon Ryan, PhD Bioinformatician / Data manager Bioinformatics Core Facility Max Planck Institute for Immunobiology and Epigenetics Email: dpry...@gmail.com