The determinant of large matrices can not be computed in a reasonable
way. Take the matrix 0.1*I, for example. If the identity matrix I is of
size n times n, then the determinant det(0.1*I)=0.1^n, which you cannot
compute if n>310 because the smallest floating point number that can be
represented is around 1e-308. Of course n=310 is a pretty small matrix.
There is of course also the issue that computing the determinant is an
exceptionally expensive operation (at least n^3).
If you're interested in the smallest eigenvalue, compute that rather
than the determinant.
Best
W.