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Maria Paula Rodriguez
Apr 3
model residuals/fit and clAIC implementation
Hi Ryan, I have two main questions related with model fit/comparison, and I'd appreciate your
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model residuals/fit and clAIC implementation
Hi Ryan, I have two main questions related with model fit/comparison, and I'd appreciate your
Apr 3
Isaac Linn
,
Ryan Gutenkunst
6
Apr 2
Running dadi using variant-only vcf as input?
Hello Isaac, If I'm reading the old paper correctly (and quickly), your ancestral population size
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Running dadi using variant-only vcf as input?
Hello Isaac, If I'm reading the old paper correctly (and quickly), your ancestral population size
Apr 2
Sarah Babaei
,
Ryan Gutenkunst
3
Mar 29
Interpreting Residuals
Hello Sarah, Neither of these residual plots shows strong underprediction of singletons, son I'm
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Interpreting Residuals
Hello Sarah, Neither of these residual plots shows strong underprediction of singletons, son I'm
Mar 29
Hana Majerova
,
Ryan Gutenkunst
7
Mar 29
Gim statistic, model comparisions
Hi Hana, Regarding the uncertainties and step size, what you're looking for is (rough)
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Gim statistic, model comparisions
Hi Hana, Regarding the uncertainties and step size, what you're looking for is (rough)
Mar 29
Reuben Ockman
,
Ryan Gutenkunst
2
Mar 29
All Models Collapsing at same place
Hello Reuben, I'm not sure what you mean by “collapse at the same place”. The drop at frequency
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All Models Collapsing at same place
Hello Reuben, I'm not sure what you mean by “collapse at the same place”. The drop at frequency
Mar 29
Emma Howell
,
Ryan Gutenkunst
4
Mar 24
Interpreting mu and sigma for DFE PDFs
Hi Emma, We typically just constrain the sigma to be positive and not huge (maybe < 10). In regard
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Interpreting mu and sigma for DFE PDFs
Hi Emma, We typically just constrain the sigma to be positive and not huge (maybe < 10). In regard
Mar 24
Clemens Maylandt
,
Ryan Gutenkunst
2
Mar 23
Estimation of L in Stairway Plots using RAD-seq
Hello Clemens, I've not used Stacks before, but based on another user's reports… I would use
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Estimation of L in Stairway Plots using RAD-seq
Hello Clemens, I've not used Stacks before, but based on another user's reports… I would use
Mar 23
Diego V
, …
Maria Paula Rodriguez
6
Mar 16
How to estimate the composite likelihood AIC (CLAIC) with DaDi?
Hi Diego and Ryan, I came across this post because I'm interested in giving a try to CLAIC to
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How to estimate the composite likelihood AIC (CLAIC) with DaDi?
Hi Diego and Ryan, I came across this post because I'm interested in giving a try to CLAIC to
Mar 16
Sarah Babaei
,
Ryan Gutenkunst
4
Mar 11
Split Time Interpretation
Hi Sarah, For L, what we're trying to calculate is the amount of sequence from which SNPs could
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Split Time Interpretation
Hi Sarah, For L, what we're trying to calculate is the amount of sequence from which SNPs could
Mar 11
Marek Šlenker
,
Ryan Gutenkunst
3
Mar 11
Too Red to Be True: Do Bad Residuals Necessarily Reject the Model?
Dear Ryan, thanks for your reply. That point about random variance within residuals seems reasonable.
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Too Red to Be True: Do Bad Residuals Necessarily Reject the Model?
Dear Ryan, thanks for your reply. That point about random variance within residuals seems reasonable.
Mar 11
Maycon Oliveira
,
Ryan Gutenkunst
9
Mar 10
dadi-cli runs take very long
Hello Maycon, If the bounds of the more complex model were a superset of the less complex model, then
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dadi-cli runs take very long
Hello Maycon, If the bounds of the more complex model were a superset of the less complex model, then
Mar 10
Maria Paula Rodriguez
,
Ryan Gutenkunst
4
Mar 6
2D data SFS with very low entries - problems with input for inference?
Hi Ryan, Thanks for your fast reply! That was the result of a single fit. What you say about the
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2D data SFS with very low entries - problems with input for inference?
Hi Ryan, Thanks for your fast reply! That was the result of a single fit. What you say about the
Mar 6
Maycon Oliveira
,
Ryan Gutenkunst
4
Mar 4
Units for time estimates
Yes, that should work. On Mar 4, 2026, at 4:53 AM, Maycon Oliveira <oliveira...@gmail.com>
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Units for time estimates
Yes, that should work. On Mar 4, 2026, at 4:53 AM, Maycon Oliveira <oliveira...@gmail.com>
Mar 4
Maycon Oliveira
,
Travis Struck
2
Mar 2
dadi-cli GenerateFs --bootstrap generates unfolded FS by default
Hi Maycon, I've pushed a fix to the GitHub source code and PyPi. The fix should be on conda-forge
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dadi-cli GenerateFs --bootstrap generates unfolded FS by default
Hi Maycon, I've pushed a fix to the GitHub source code and PyPi. The fix should be on conda-forge
Mar 2
Cameron Grey
,
Ryan Gutenkunst
4
Jan 29
Expansion/migration script and random seeding questions
Hello Cameron, Retaining one SNP per RAD locus is a typical approach that I find sensible. That seems
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Expansion/migration script and random seeding questions
Hello Cameron, Retaining one SNP per RAD locus is a typical approach that I find sensible. That seems
Jan 29
Maycon Oliveira
,
Ryan Gutenkunst
4
Jan 20
Data dimensions after fold()
Hello Maycon, Yes, the sparseness is due to many zeros in your data. You can project down to fill it
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Data dimensions after fold()
Hello Maycon, Yes, the sparseness is due to many zeros in your data. You can project down to fill it
Jan 20
Ryan Gutenkunst
,
Kaden Winspear
2
Jan 19
Re: [dadi-user] Projection Choice - 2D models
Thank you for the help! On Mon, Jan 19, 2026 at 1:42 PM Ryan Gutenkunst <rgute...@gmail.com>
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Re: [dadi-user] Projection Choice - 2D models
Thank you for the help! On Mon, Jan 19, 2026 at 1:42 PM Ryan Gutenkunst <rgute...@gmail.com>
Jan 19
RAYIS T R
,
Ryan Gutenkunst
3
Jan 13
Some Questions on dadi-cli
Thanks, Ryan! This is very helpful. On Sunday, January 11, 2026 at 4:22:27 AM UTC+5:30 Ryan
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Some Questions on dadi-cli
Thanks, Ryan! This is very helpful. On Sunday, January 11, 2026 at 4:22:27 AM UTC+5:30 Ryan
Jan 13
Laura Méndez Cuéllar
, …
RAYIS T R
5
Jan 9
AttributeError: 'MaskedArray' object has no attribute 'folded'
Hi Ryan, Thanks for the response. I started using dadi-cli for my analysis and had some questions
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AttributeError: 'MaskedArray' object has no attribute 'folded'
Hi Ryan, Thanks for the response. I started using dadi-cli for my analysis and had some questions
Jan 9
宋炎峰
, …
Ryan Gutenkunst
10
12/1/25
Inquiry on Performing LRT Between Allotetra & Seg-Allotetra Models in dadi Pipeline
Given that neither models fits the data well, and your data don't show evidence of the expected
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Inquiry on Performing LRT Between Allotetra & Seg-Allotetra Models in dadi Pipeline
Given that neither models fits the data well, and your data don't show evidence of the expected
12/1/25
Abby Williams
,
Ryan Gutenkunst
2
9/6/25
Comparing non-nested models with linked SNPs
Hello Abby, I'm sorry I don't have a very satisfying answer. My group's approach is
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Comparing non-nested models with linked SNPs
Hello Abby, I'm sorry I don't have a very satisfying answer. My group's approach is
9/6/25
Gutenkunst, Ryan N - (rgutenk)
8/25/25
Other:GenomicHistory.Inference.StrategiesTournament
Hello dadi users! The 2025 Genomic History Inference Strategies Tournament (GHIST) is live at https:/
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Other:GenomicHistory.Inference.StrategiesTournament
Hello dadi users! The 2025 Genomic History Inference Strategies Tournament (GHIST) is live at https:/
8/25/25
Skye Davis
,
Ryan Gutenkunst
2
8/17/25
Understanding LRT
Hello Skye, No apologies needed. This is generally confusing. :-) For symmetric versus asymmetric
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Understanding LRT
Hello Skye, No apologies needed. This is generally confusing. :-) For symmetric versus asymmetric
8/17/25
Emma Howell
,
Ryan Gutenkunst
2
7/31/25
Testing for distinct marginal DFEs in a joint DFE context
Hello Emma, Sorry for the slow reply. This is a subtle issue, and I don't think we have a great
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Testing for distinct marginal DFEs in a joint DFE context
Hello Emma, Sorry for the slow reply. This is a subtle issue, and I don't think we have a great
7/31/25
Ryan Gutenkunst
7/19/25
Re: [dadi-user] Seeking Help with Model Selection Instability in dadi
Hello Fred, Sorry for the slow reply. I've been on vacation. I'm not deeply familiar with the
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Re: [dadi-user] Seeking Help with Model Selection Instability in dadi
Hello Fred, Sorry for the slow reply. I've been on vacation. I'm not deeply familiar with the
7/19/25
Sofia Hayden Bofill
,
Ryan Gutenkunst
3
7/7/25
Converting migration fraction to number of migrants
Hi Ryan, Thank you so much for your quick reply, I really appreciate it. Amazing, now it is clear.
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Converting migration fraction to number of migrants
Hi Ryan, Thank you so much for your quick reply, I really appreciate it. Amazing, now it is clear.
7/7/25
dadi-user
7/6/25
Seeking Help with Model Selection Instability in dadi
Hi, I am writing to seek your expertise regarding an issue I've encountered while using dadi for
unread,
Seeking Help with Model Selection Instability in dadi
Hi, I am writing to seek your expertise regarding an issue I've encountered while using dadi for
7/6/25
Sarah Babaei
,
Ryan Gutenkunst
4
7/1/25
2D sfs and results interpretation
Hi Sarah, Replies below On Jul 1, 2025, at 11:20 AM, Sarah Babaei <sarahba...@gmail.com>
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2D sfs and results interpretation
Hi Sarah, Replies below On Jul 1, 2025, at 11:20 AM, Sarah Babaei <sarahba...@gmail.com>
7/1/25
Panos Zerv
,
Ryan Gutenkunst
2
5/19/25
dadi-cli optimization method
Hello Panagiotis, There is not currently a way to specify the optimization method in dadi-cli. If you
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dadi-cli optimization method
Hello Panagiotis, There is not currently a way to specify the optimization method in dadi-cli. If you
5/19/25
Linda H
,
Ryan Gutenkunst
5
4/8/25
low theta, strange parameter values
Hi Ryan, Thanks for clarifying down-projection, it really doesn't seem to be useful in this case.
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low theta, strange parameter values
Hi Ryan, Thanks for clarifying down-projection, it really doesn't seem to be useful in this case.
4/8/25