Certainly. All Cytoscape-provided layouts are tunable, including Prefuse Force Directed. And tunables are supported by automation. Open up the Layout > Settings dialog to become familiar with the parameters you can tune (See video:
https://www.youtube.com/watch?v=YPdbjIDD9vA). Then open the Automation Panel (View menu) to test out your scripting syntax, e.g.,
help layout force-directed # will display names for all parameters
layout force-directed defaultSpringLength=30. # will perform the layout with a shorter default edge length
Finally, if you are running your scripts in R, you can use the RCy3 function, like so:
layoutNetwork('force-directed defaultSpringCoefficient=0.0000005’). # will perform the layout with looser springs
Include as many tunable parameters as you like, space separated.
Hope this helps!