ClueGO: not able to update KEGG pathway database

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sandy...@gmail.com

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Aug 6, 2018, 2:02:46 AM8/6/18
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Hi,

I got an error when updating the KEGG pathway data in ClueGO - it is related to http://rest.kegg.jp/get/hsa04933 which caused the updating process to terminate. Any clue to resolve this?

Thank you!

Best regards,
Sandy

Bernhard

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Aug 9, 2018, 2:19:39 PM8/9/18
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Hi Sandy, could you give us more details? Perhaps run ClueGO from a terminal and send us the output when it happens. We tried to update KEGG for human and it works.
Best

sandy...@gmail.com

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Aug 9, 2018, 9:59:18 PM8/9/18
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Hi Bernhard,

Thanks so much for following up. I was running ClueGo as cytoscape plugin, and on choosing the "Update Ontologies" & "KEGG - Update KEGG Pathways", this error message popped up:

"Internet connection seems to be interrupted or the link has changed: Server returned HTTP response code: 403 for URL: http://rest.kegg.jp/get/hsa04810. Check in the *.properties file in the /your_home_folder/ClueGOSourceFiles/Homo Sapiens/ folder!"

The problem is definitely not due to internet connection, but the "Homo Sapiens_KEGG_Pathways_[download date].txt.gz" file downloaded to the folder in the error message is incomplete - extracting the file gives the error "unexpected end of data". I guess there is probably problem with http://rest.kegg.jp/get/hsa04810 that caused the download termination?

Thank you very much!

Best regards,
Sandy

Bernhard

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Aug 10, 2018, 5:34:06 AM8/10/18
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Hi Sandy, the link seems to work now. Probably it was just a maintenance of KEGG but it is working again. Did you try to update again, and do you still get the error?
Best

Sandy Lam

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Aug 10, 2018, 7:10:22 AM8/10/18
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Hi Bernhard,

I just tried with my laptop (previously with PC), the problem persists. But an interesting observation was that, the % of download completed at the moment the error message popped up varied in different update attempts (e.g. 61%, 72%, 76%), and so did the URL showed by the error message (e.g. http://rest.kegg.jp/get/hsa04721, 04975...). Would it be that the error message was due to some time limit in downloading the pathway file?

The update I chose in the pull-down box is "KEGG - update KEGG pathways".

Thank you!

Sandy

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