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Hi Rono,
The main recommendation I made in the bug was to use Force Directed,
which uses significantly less memory. There is no real way to fix the
out-of-memory problem, but I did fix it so that it doesn't throw an NPE
exception. The fix will be in the next release of Cytoscape - 2.7.0, or
you can build a fresh Cytoscape from source. Alternatively, if you
really want to use Spring Embedded, you can allocate Cytoscape a *lot*
of memory. I was able to get BINDyeast.sif to layout using
Spring-Embedded on a Cytoscape instance that had 8GB allocated.
-- scooter