NEW Cytoscape plugin: iCTNet 1.0

[Sergio Baranzini]

Dear all,

WE are happy to announce the release of a new Cytoscape plugin: iCTNet (integrated Complex Traits Networks)

iCTNet uses public information on genomics, gene expression, protein interaction, TF binding sites and drug-targets to create multi-partite networks that allow the study of genetic similarities and differences across diseases, shared susceptibility pathways and potential off-label use of FDA-approved drugs.

The current version of iCTNet currently has

·         More than 200 complex traits/diseases

·         More than 33,000 interactions among 12,000 proteins from the human protein reference database (HPRD)

·         More than 13,000 genes mapped to 27 tissues, and 247 phenotypes

·         More than 2,400 FDA-approved drugs and their 1,739 gene targets

·         More data will be added in subsequent versions

 

The plugin and database connector can be downloaded here

 

http://www.cs.queensu.ca/ictnet

 

 

 

 

Enjoy!

 

Sergio

 

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Sergio E Baranzini, Ph.D.

Associate Professor

Heidrich Family and Friends Endowed Chair in Neurology

Department of Neurology,

University of California San Francisco

513 Parnassus Ave. Room S-256.

San Francisco, CA 94143-0435

Ph:415-502-6865 FAX: 415-476-5229

e-mail: seb...@cgl.ucsf.edu