Hi Andrey,
I've tested the P3 instance using an NVIDIA container with RELION2 installed and I saw a similar result as that mentioned on the RELION website, although not quite as fast with 4 x V100. This, considering the cost, made me decide that g3 and p2 instances are still worth it for us.
Regarding C5, I haven't had the need for CPU calculations, so I don't know much about how it will affect cryo-EM jobs.
Mike