I have two Cromemco System One chassis -- one is rigged up for CDOS/CPM 2.2 with ZPU, 16FDC, and a 512KZ (I can add a TUART when I need extra serial lines). I think I can also run Z80 Cromix, but don't quote me on that! It uses the IDE/CF card from the S100computers group, so CP/M has sixteen 8 MB "drives". It boots into ITC CP/M from 5.25" HD the floppy drive (there are 3, but one is dying!), but then I run a little chunk of code I wrote to switch over to the compact flash card. Right now, I have no access to the floppies from the system on compact flash. I do all my file transfer via XMODEM.
The second System One is rigged up for Cromix with an XPU, 32FDC, and two 512KZs. I'm limited to what I can do here because I have no hard drive ... just four 5.25" HD floppy drives. Also do not have much in the way of application software. Just SBASIC(?) (I think that's right).