Clinical Pharmacokinetics And Pharmacodynamics: Concepts And Applications
Christel Malden
Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.
Understanding the science of pharmacokinetics is a challenge for many pharmacy students and practitioners. Concepts in Clinical Pharmacokinetics, now in its 7th edition, has helped thousands by simplifying this essential, but complex, subject to reflect current practice. The 7th edition has been revised by Robin Southwood, PharmD, BC-ADM, CDE; Virginia H. Fleming, PharmD, BCPS; and Gary Huckaby, PharmD; all experts in clinical pharmacy education. Together, they have updated and expanded the text to include the latest information and insights on concepts through extensive use of correlates, figures, and review questions.
Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications
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Concepts in Clinical Pharmacokinetics, 7th edition, is the fundamental reference for learning the basic, foundational pharmacokinetics concepts and how to apply them to dosing of drugs in clinical practice. Content is broken into 15 easy-to-follow lessons, perfect for a semester.
PCEUT 201 Drug Discovery, Development and Beyond: Careers and Controversies (3) NSc
Introduces students to drug development from discovery to drug approval with an emphasis on careers and the scientific and ethical issues at each stage. Recommended for undergraduate health science majors and non-science majors. Recommended: basic high school knowledge of general chemistry and biology. Offered: W.
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PCEUT 502 Drug Disposition Science (2)
Introduction to drug metabolism and transport pharmacokinetics. Topics include basic processes of drug absorption, distribution and elimination, enzyme/transporter kinetics, associated experimental methodologies for generating kinetic parameter estimates, and principles of drug-drug interactions and other sources of inter-individual variability. Covers experimental rigor and reproducibility and research ethics. Recommended: biochemistry. Offered: A.
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PCEUT 503 Principles of Drug Transport (3)
Provides an advanced understanding of major solute carrier (SLC) and ATP-binding cassette (ABC) drug transporters and their roles in drug absorption, distribution and excretion. Topics include major drug transporter families, transport processes in drug disposition organs, experimental approaches to study transporters, and application of drug transporter research in drug development and drug-drug interaction evaluation. Prerequisite: either PCEUT 502, PCEUT 532, or permission of the instructor. Offered: Sp, odd years.
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PCEUT 505 Concepts in Pharmaceutical Sciences I (2)
Provides the student with foundational knowledge of drug properties and interaction with physiology upon administration in vivo, and an understanding of pharmaceutical formulation which is a key disciplinary area within the pharmaceutical sciences and its application to small molecules and protein-based therapeutics. Offered: A.
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PCEUT 506 Concepts in Pharmacokinetics (3)
Theory and practice. Includes principles of physiological basis of pharmacokinetics, a mechanistic understanding of pharmacokinetic parameters, and the ability to derive basic pharmacokinetic equations and concepts. Prerequisite: PCEUT532, which may be taken concurrently. Offered: W.
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PCEUT 513 Basic Concepts in Pharmacogenetics and Toxicogenomics (3)
Addresses current technologies for DNA sequencing, genotyping, RNA and epigenetic analysis and basic concepts of pharmacogenetics and toxicogenomics. Emphasis placed on applications of genomic technologies to the understanding of "gene-environment interactions" that cause variability in drug treatment responses, as well as diseases of public health importance, including cancer, chronic neurological diseases, and adverse drug reactions. Offered: jointly with ENV H 513/PHG 513; W.
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PCEUT 531 Pharmaceutical Formulation: Principles and Dosage Forms (4)
Provides knowledge base for subsequent pharmacy courses and professional practice. Theory and problems involved in incorporating drugs into stable dosage forms suitable for human use and intended routes of drug administration. Fundamentals of safe and appropriate handling and use of dosage forms. Common dosage forms and basic compounding skills. Recommended: general chemistry. Offered: A.
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PCEUT 532 Clinical Pharmacokinetics (4)
Covers basic principles of pharmacokinetics and their application to the clinical setting. Includes the design of an appropriate dosing regimen, such as single-dose intravenous and oral administration, multiple dosing, nonlinear pharmacokinetics, metabolite kinetics, pharmacodynamics, inter-individual variability and the physiological basis of pharmacokinetics. Prerequisite: PCEUT 531. Offered: W.
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PCEUT 534 Principles of Precision Medicine (2)
Variation in drug absorption, distribution, elimination, and response, with emphasis on pharmacokinetic-pharmacodynamic relationships. Includes pharmacogenetics, drug-drug interactions, as well as ontogenic and disease state effects and associated precision testing platforms. Uses case studies to integrate possible sources of variation and impact on individual therapeutic decisions. Prerequisite: either MEDCH 501; PCEUT 531; and PCEUT 532, or permission of instructor; recommended: basic understanding of pharmacokinetics and principles of drug absorption, distribution and elimination and drug response. Offered: Sp.
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PCEUT 537 Chemical and Molecular Pharmacology III: Cancer Treatments and Biotherapeutics (4)
Cancer biology and agents used in cancer treatment and supportive care. Mechanisms of action and toxicities of agents. Formulating and optimizing dosage forms for small molecules and protein drugs. Major biopharmaceutical products (e.g., monoclonal antibodies, endogenous protein replacement) and their unique characteristics. Prerequisite: either PCEUT 531; PCEUT 532; and MEDCH 501, or permission of instructor. Offered: Sp.
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PCEUT 570 Advanced Research Topics (1, max. 15)
Combines a discussion of the practical aspects and experimental techniques used to address the questions relating to drug disposition with comprehensive theoretical treatment of pharmacokinetic principles. Prerequisite: permission of the instructor. Credit/no-credit only.
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PCEUT 580 Current Trends in Pharmacy Science and Practice (1, max. 2)
Builds on fundamental and foundational knowledge of advanced professional pharmacy students. Research in pharmacy sciences: translational, clinical, outcomes, or related to scholarship within the School of Pharmacy, or related department and institutions. Prerequisite: School of Pharmacy professional or graduate student standing. Undergraduate students with permission of instructor. Credit/no-credit only. Offered: W.
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PCEUT 586 Biotechnology and Biopharmaceutics (2-3)
Current topics in pharmaceuticals and biotechnology focusing on transforming small molecules, proteins, and genes into therapeutic products. Includes new drug therapies, drug design, pharmacogenomics, molecular modeling, high throughput screen, production and stability considerations, and delivery systems of protein and gene therapeutics in relation to pharmacokinetic and therapeutic responses.
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Updated with the latest clinical advances, Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition, explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
AMIT PAI is Professor of Clinical Pharmacy with expertise in precision dosage regimen design. He has extensive training in clinical pharmacology and drug development, with specific expertise in clinical pharmacokinetics/pharmacodynamics (PK/PD). His experiences span from in vitro studies to characterize antifungal pharmacodynamics, pre-clinical studies to evaluate toxicology, use of semi-invasive and non-invasive methods to characterize drug biodistribution, to the translation of these findings to design novel formulations to optimize PK/PD. During his first academic appointment, he completed a 2-year general clinical research center scholars program followed by a 2-year clinical translational science center (KL2) scholars program. His research expertise includes application of population PK Modeling to advocate for changes to current drug dosing paradigms.
He also currently serves as the Deputy Director of the PK Core that is a shared resource for the University of Michigan. (www.pkcore.org). This resource maintains six mass spectrometers including two newly acquired state-of-the-art instruments to support high resolution mass spectrometry and imaging mass spectrometry (DESI and MALDI based applications). This Mass spectrometry and Pharmacokinetics core has dedicated analytical chemistry staff, in vivo pre-clincial staff, and clinical research staff to support drug discovery and development.
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