BUY Carfentanil POWDER

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BUY Carfentanil POWDER
Buy Carfentanil POWDER or carfentanyl is a structural analog of the synthetic opioid analgesic fentanyl. Short acting and with fast onset, it has, weight for weight, around one hundred times stronger effects than fentanyl and thousands of times stronger than heroin. It is more effective at reducing pain response in rats than any other opioid.

Carfentanil was first synthesized in 1974 by a team of chemists at Janssen Pharmaceutica which included Paul Janssen.

The effects of carfentanil, including overdose, can be reversed by naloxone.

Carfentanil is legally controlled in most jurisdictions, but has veterinary uses for anaesthetising large animals.

Typical use
Carfentanil was sold starting in 1986 under the brand name “Wildnil” for use in tranquilizer darts in combination with an ?2-adrenoreceptor agonist for large mammals including elk and elephants. It was chosen for its high therapeutic index. Commercial production of Wildnil ceased in 2003, and the drug is available only as a compounded dosage form.

Radiolabelled [11C]carfentanil is widely used as a selective radiotracer in animal and human positron emission tomography (PET) imaging studies of the ?-opioid system due to its high affinity for receptors.

Importation from China
According to an Associated Press article from 2016, “Chemical weapon for sale: China’s unregulated narcotic”, fentanyl, carfentanil and other highly potent derivatives of fentanyl are actively marketed by several Chinese chemical companies. Carfentanil was not a controlled substance in China until 1 March 2017, and until then was manufactured legally and sold openly over the Internet.

Authorities in Latvia and Lithuania reported seizing carfentanil as an illicit drug in the early 2000s. Around 2016, the US and Canada started reporting a dramatic increase in shipment of carfentanil and other strong opioid drugs to customers in North America from Chinese chemical supply firms. In June 2016 the Royal Canadian Mounted Police seized one kilogram of carfentanil shipped from China in a box labeled “printer accessories”. According to the Canada Border Services Agency, the shipment contained 50 million lethal doses of the drug, more than enough to wipe out the entire population of the country, in containers labeled as toner cartridges for Hewlett-Packard LaserJet printers. Allan Lai, an officer-in-charge at the Royal Canadian Mounted Police in Calgary who helped oversee the criminal investigation said, “With respect to carfentanil, we don’t know why a substance of that potency is coming into our country.

Pharmacology
Carfentanil is a lipophilic chemical, and hence can much more easily cross the blood-brain barrier. :pg 9 It thus has very rapid onset of effects, but is also shorter acting.

For pain relief, a unit of carfentanil is 100 times as potent as the same amount of fentanyl, 5,000 times as potent as a unit of heroin and 10,000 times as potent as a unit of morphine. This is despite only having 14-135 times higher affinity for the ? receptor.

Legal status
China
Carfentanil has been controlled in China since 1 March 2017. The trade war between China and the US has included controversy over the effectiveness of this control.

United States
Carfentanil is classified as Schedule II under the Controlled Substances Act in the United States with a DEA ACSCN of 9743 and a 2016 annual aggregate manufacturing quota of 19 grams (less than 0.7 oz.).

United Kingdom
Carfentanil has been specifically controlled as a Class A drug since 1986

Chemical and physical data
Formula: C24H30N2O3

Molar mass: 394.515 g·mol?1

See also
4-Phenylfentanyl
Lofentanil (3-methylcarfentanyl)
N-Methylcarfentanil
Sufentanil
Thiafentanil
Opioid comparison
R-30490 (4-methoxymethylfentanyl)

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BUY Thiafentanil POWDER
BUY Thiafentanil POWDER (A-3080, Thianil) is a highly potent opioid analgesic that is an analog of fentanyl, and was invented in 1986. It is similar to carfentanil though with a faster onset of effects, shorter duration of action and a slightly lesser tendency to produce respiratory depression. It is used in veterinary medicine to anesthetise large animals such as impala, usually in combination with other anaesthetics such as ketamine, xylazine or medetomidine to reduce the prevalence of side effects such as muscle rigidity.

Side effects
Side effects of fentanyl analogues are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Potent pure opioid antagonists such as naltrexone or nalmefene are recommended in the event of accidental human exposure to thiafentanil. Fentanyl analogues have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.

Legal status
Thiafentanil is a Schedule II controlled drug in the USA since August 2016.

Chemical and physical data
Formula: C22H28N2O4S

Molar mass: 416.54 g·mol?1

See also
Sufentanil
List of fentanyl analogues

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BUY Trefentanyl POWDER
Trefentanyl POWDER (A-3665) is an opioid analgesic that is an analogue of fentanyl and was developed in 1992.

Trefentanil is most similar to short-acting fentanyl analogues such as alfentanil. In comparative studies, trefentanil was slightly more potent and shorter acting than alfentanil as an analgesic, but induced significantly more severe respiratory depression. For this reason trefentanil has not been adopted for clinical use, although it is still used in research.

Trefentanil has very similar effects to alfentanil, much like those of fentanyl itself but more potent and shorter lasting. Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. The risk of respiratory depression is especially high with potent fentanyl analogues such as alfentanil and trefentanil, and these drugs pose a significant risk of death if used outside of a hospital setting with appropriate artificial breathing apparatus available.

Clinical data
ATC code: none

Chemical and physical data
Formula: C25H31FN6O2

Molar mass: 466.551 g/mol g·mol?1

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Buy 4-fluoroisobutyrfentanyl powder
Buy 4-fluoroisobutyrfentanyl powder (also known as 4-FIBF and p-FIBF) is an opioida is an analog of butyrfentanyl and structural isomer of 4-Fluorobutyrfentanyl and has been sold online as a designer drug. It is closely related to 4-fluorofentanyl, which has an EC50 value of 4.2 nM for the human ?-opioid receptor.

DESCRIPTION
Names: 4-Fluoroisobutyrfentanyl para-fluoroisobutyrfentanyl, N-(4-fluorophenyl)-N-(1-phenethylpiperidin 4-yl)isobutyramide pFIBF, 4-FIBF,

IUPAC name: N-(4-fluorophenyl)-N-(1-phenethylpiperidin-4-yl)isobutyramide

Substance group: Other substances

This substance is included in Schedule I of the 1961 Single Convention on Narcotic Drugs

InChI
InChI=1S/C23H29FN2O/c1-18(2)23(27)26(21-10-8-20(24)9-11-21)22-13-16-25(17-14-22)15-12-19-6-4-3-5-7-19/h3-11,18,22H,12-17H2,1-2H3

InChI Key: OZDOSQNUJIXEOR-UHFFFAOYSA-N SMILES: O=C(C(C)C)N(C1=CC=C(F)C=C1)C2CCN(CCC3=CC=CC=C3)CC2

Formula: C23H29FN2O

Molar mass: 368.50 g·mol?1

Side effects
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.

Legality
4-Fluoroisobutyrylfentanyl is a Schedule I controlled substance in the United States. In the UK, it is a Class A drug. In Canada, it is a Schedule I drug.

See also
3-Methylbutyrfentanyl
3-Methylfentanyl
4-Fluorofentanyl
?-Methylfentanyl
Acetylfentanyl
Acrylfentanyl
Furanylfentanyl
List of fentanyl analogues
Fentanyl analogues, in which the N-[1-(2-phenethyl)-4-piperidyl]aniline nucleus has additional radicals, either alone or in combination, attached as follows:

(a) an acetyl, propionyl, butenoyl or butanoyl radical, attached to the aniline nitrogen atom:

(b) 1 or more alkyl radicals, with up to 10 carbon atoms in total, attached to the ethyl moiety:

(c) any combination of up to 5 alkyl radicals and/or alkoxy radicals (each with up to 6 carbon atoms, including cyclic radicals) and/or halogen radicals, attached to each of the benzene rings

fentanyl-related substances includes any substance not otherwise controlled in any schedule…that is structurally related to fentanyl by one or more of the following modifications:

Replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle;
substitution in or on the phenethyl group with alkyl, alkenyl, alkoxyl, hydroxyl, halo, haloalkyl, amino or nitro groups;
substitution in or on the piperidine ring with alkyl, alkenyl, alkoxyl, ester, ether, hydroxyl, halo, haloalkyl, amino or nitro groups;
replacement of the aniline ring with any aromatic monocycle whether or not further substituted in or on the aromatic monocycle; and/or
replacement of the N-propionyl group by another acyl group.

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ADB-FUBINACA is a designer drug identified in synthetic cannabis blends in Japan in 2013. In 2018, it was the third-most common synthetic cannabinoid identified in drugs seized by the Drug Enforcement Agency.

The (S)-enantiomer of ADB-FUBINACA is described in a 2009 Pfizer patent and has been reported to be a potent agonist of the CB1 receptor and the CB2 receptor with EC50 values of 1.2 nM and 3.5 nM, respectively. ADB-FUBINACA features a carboxamide group at the 3-indazole position, like SDB-001 and STS-135. ADB-FUBINACA appears to be the product of rational drug design, since it differs from AB-FUBINACA only by the replacement of the isopropyl group with a tert-butyl group.

An analogue of ADB-FUBINACA, ADSB-FUB-187, containing a more functionalized carboxamide substituent was recently reported.

Technical Information
Formal Name: N-[1-(aminocarbonyl)-2,2-dimethylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide
CAS Number: 1445583-51-6
Molecular Formula: C21H23FN4O2
Formula Weight: 382.4
Purity: ?98%
Formulation: A neat solid
SMILES: O=C(NC(C(N)=O)C(C)(C)C)C1=NN(CC2=CC=C(F)C=C2)C3=C1C=CC=C3
InChi CodeInChI=1S/C21H23FN4O2/c1-21(2,3)18(19(23)27)24-20(28)17-15-6-4-5-7-16(15)26(25-17)12-13-8-10-14(22)11-9-13/h4-11,18H,12H2,1-3H3,(H2,23,27)(H,24,28)
InChi Key: ZSSGCSINPVBLQD-UHFFFAOYSA-N
DEA Schedule: I
Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ? 3 years
Legality
In the United States, ADB-FUBINACA is a Schedule I controlled substance.

Metabolism
Twenty-three ADB-FUBINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic pathways were alkyl and indazole hydroxylation, terminal amide hydrolysis, subsequent glucuronide conjugations, and dehydrogenation

Side effects
One death through coronary arterial thrombosis has been linked to ADB-FUBINACA intoxication.

At least an additional 8 deaths in Hungary in 2015 are linked to the usage of this material, all deaths were youngsters below 21.

WARNING This product is not for human or veterinary use.

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Buy MDMB-FUBINACA Powder is a designer drug identified in synthetic cannabis blends in Japan in 2013. In 2018, it was the third-most common synthetic cannabinoid identified in drugs seized by the Drug Enforcement Agency.

The (S)-enantiomer of MDMB-FUBINACA Powder is described in a 2009 Pfizer patent and has been reported to be a potent agonist of the CB1 receptor and the CB2 receptor with EC50 values of 1.2 nM and 3.5 nM, respectively. MDMB-FUBINACA Powder features a carboxamide group at the 3-indazole position, like SDB-001 and STS-135. MDMB-FUBINACA Powder appears to be the product of rational drug design, since it differs from AB-FUBINACA only by the replacement of the isopropyl group with a tert-butyl group.

An analogue of MDMB-FUBINACA Powder, ADSB-FUB-187, containing a more functionalized carboxamide substituent was recently reported.

Side effects
One death through coronary arterial thrombosis has been linked to MDMB-FUBINACA Powder intoxication.

At least an additional 8 deaths in Hungary in 2015 are linked to the usage of this material, all deaths were youngsters below 21.