Hello,
I am trying to run a parameter estimation for the attached model. I have the starting model (ERK_Akt_Wnt_SBML.cps), and I added one reaction and modified another reaction (ERK_AKT_Wnt_SBML_Muc1NGal.cps), but the lack of kinetics studies leaves me no choice but to estimate the parameters computationally to normalize the second model with respect to the original one.
Basically, I added the reaction Galectin Binding, for which I don't really know the parameters except the ratio kf/kr, and modified the reaction v2 (so I want to estimate its k1 and k2).
As experimental data, I uploaded the time course txt file from the original model (the one before I made the changes mentioned above).
I wanted to view only the weighted errors in the plot, so when I go to the output specifications to delete the measured and fitted curves, COPASI crashes and gives the following error: ./CopasiUI: line 28: 29722 Segmentation fault "${CopasiUI}" "$@"
I am not sure what is causing this error. I am using the latest version for Linux64.
Thanks for the help in advance
Emre