I hope this finds you well!
I've been having trouble with my model recently in COPASI. Parameter Estimation is very slow all of a sudden and there are certain parameter combinations for which the time-course simulations are not able to be solved.
I thought failing to solve an ODE can happen when some reactions are too quick to be solved with a given timestep. But changing the timestep and interval etc seem to have little if any effect. Additionally it appears to happen even when I reduce rate constants, not increase them up (hence reactions should be slower if anything).
Additionally, I'm having trouble doing Parameter Estimation now. Previously I was able to calculate around 90-100 Evaluations/second on my laptop but it is now at 1.26 Evaluations/second...
Could there be some mistake or error somewhere in my model causing this? Or could having many plots and global quantities be causing an issue? Are there any things that are generally recommended for speeding up computation time in COPASI?
Thank you for any help you can offer, (my COPASI file is attached, though without the Experimental data in Parameter Estimation)
I hope the questions aren't too much too!
I really appreciate the service you all provide with this User Forum and COPASI itself is a really impressive software!