Interesting discussion, because I have never used the stuff.
Hard racing copper was best in the Essex creeks back in Pommyland, then TBT worked well for years until banned.
Now I use Altex but for the prop, use a Hard anti foul and a layer of soft over the top. New experiment this year as it was very highly recommended by the yard here
Re the actual discussion in hand though - there are application issues with many substances and the tried and tested mantra is always - do not mix the manufacturers. Having said that, I prefer to look at the chemistry when I can get enough info.
Part of the problem with the old zinc chromate primer was that it formed a skin after too many hours and any subsequent layer peeled off. I am slightly cautious at the use of the zinc chromate, which is an oil based product typically, and suspect it is more technically advanced than that. I am only a mere mechanical engineer and need to consult a good chemical wallah for a chat.
As far as going-off in the pot though, I am curious as to the chemistry behind that if it still looked and behaved OK until wet. Going-off in the pot is either a vapour loss, as in normal painting processes where the solvent evaporates, or it is a chemical reaction, as in a moisture sensitive poly where the atmospheric moisture is enough to set the base.
It actually sounds like the primer was left too long before the next coat was applied.
It will be good to source some proper data and review that but I fear that even the aerial safety data sheet will not be enough