A construction like this:
\begin{frame}
\only<n>{$$E = m c^2$$}
\only<n+1>{$$\overbrace{E = m c^2}^{\text{Einstein's Big Equation}}$$}
\end{frame}
You will have to adjust the vertical and horizontal spaces according to
the effect you want.
--
François Patte
Université Paris Descartes