I've seen the Skyrim CTD attributed to everything from video drivers
to sound drivers to BIOS versions out of date, etc.
In my case, sound driver updates seemed to solve the problem. I had
to do them manually through the Creative updater, do not rely on
Windows update to be a single source update. Video and sound drivers
have been culprits as long as they've been around, and things have
gotten a lot better but they are still the first places to look in a
relatively open environment like the PC (as opposed to Mac where you
cannot play Skyrim at all due to the shitty outdated hardware, or
consoles that let you play it with much less risk of crashes, but
still on shitty outdated hardware).
All hat said, the fact it CTD's at all is purely on Bethesda
Softworks. They should be displaying error messages with clues on
what's going on, but instead they've opted to simply terminate
process. They may be sending logs of CTD back home via Steam for
those playing with active internet connection so they can diagnose and
fix proactively, or maybe not. Purely a decision of the game vendor.
Historically they've done a good job of patching and keeping customers
happy, so most folks would say one crash in 6 hours is not a bad
record at all. Especially since you can hit F5 every 60 seconds if
you want, almost habitually and without notice, and the game does
autosaves for you at most important events.