I'm running mint 17.3 that way. It does boot up to a login screen, but I
never do.
ssh straight in and use CLI.
In the old days some machines wouldn't boot without a keyboard, but that
seems to be long gone.
That is really your only issue. And if it turns out to be a show
stopper, buy the cheapest USB wifi keyboard you can and shove the dongle
in a suitable orifice.
--
Truth welcomes investigation because truth knows investigation will lead
to converts. It is deception that uses all the other techniques.