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UR-144 has a high affinity for the CB2 receptor with a Ki of 1.8 nM but an 83x lower affinity for the CB1 receptor with a Ki of 150 nM. It was found to possess an EC50 of 421 nM for human CB1 receptors, and 72 nM for human CB2 receptors. UR-144 produces bradycardia and hypothermia in rats at a dose of 10 mg/kg, suggesting weak cannabinoid-like activity.
Chemically it is closely related to other 2,2,3,3-tetramethyl cyclopropyls synthetic cannabinoids like A-796,260 and A-834,735 but with a different substitution on the 1-position of the indole core, in these compounds, its 1-pentyl group is replaced with alkyl heterocycles like 1-(2-morpholino ethyl) and 1-(tetrahydropyran-4-ylmethyl).
Chemical and physical data
Formula: C21H29NO
Molar mass: 311.461 g/mol g·mol?1
Dose
Inhalation (tentative due to a lack of information)
Range: 2.5 to 20 mg
Most people have been exposed to the drug in the form of “blends” that contain varying levels of UR-144. It's not wise to use those products.
https://www.alpharcforsale.com/product/buy-ur-144-powder-online/ Timeline
Inhalation (tentative due to a lack of information)
Total: 1 – 2 hours
Onset: Under 10 minutes
See also
AB-001
AM-1221
4-HTMPIPO
FAB-144
JTE 7-31
JWH-018
N-(S)-Fenchyl-1-(2-morpholino ethyl)-7-methoxy indole-3-carboxamide
XLR-11
Tetramethylcyclopropylfentanyl
comp.dcom.sys.cisco #99790
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Subject: Buy UR-144 Powder
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