More on psychogenic blackouts [escapes] which must be prevented:
TRPV2 (also called VRL-1) responds to temperatures above 52 Celsius.
VR-1 responds to capsaicin. VRL-1 does NOT. There is a world of
VRL-1 responds only to "painfully hot"
VR-1 responds to hot, chili, and acids.
Once again, there is a BIG difference between VR-1 and VRL-1. Read
the quotes from http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Pain.html
"TRPV1 (also known as VR1) = Hot (>43 Celsius). Also activated by
capsaicin, the active ingredient of hot chili peppers, by camphor, and
by acids (protons)."
"TRPV2 (also called VRL-1) = Painfully hot (>52 Celsius)"
"VR1 for hot, and VRL1 for super hot."
In the skin, VRL-1 serves as a thermal nociceptor. However in the
viscera, lungs and other internal organs, VRL-1 has a totally
So dermal VRL1-excitation is significantly more painful than VR1