Comet 2026.01 rev. 1 is now available

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Jimmy Eng

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Mar 16, 2026, 10:22:56 PM (11 days ago) Mar 16
to Comet ms/ms db search support
Comet 2026.01 rev. 1 is now available.
Release notes:  https://uwpr.github.io/Comet/releases/release_202601.html
Download link:  https://github.com/UWPR/Comet/releases

This minor maintenance release is meant to address a bug in the v2026.01 rev. 0 release where real-time searches using fragment ion indexing through the CometWrapper.dll were not reporting the correct calculated neutral peptide mass.  Code was added to re-calculate peptide masses in post-processing to address rounding errors when peptide masses were calculated from parsing FASTA sequences.  This code was inadvertently and improperly applied to the RTS searches so this maintenance release addresses that bug. 

Updates in this release include:
  • Incorporated BS:thread_pool (C++ threads; replaces pthreads on Linux) in #109
  • The restored peptide indexing now supports Comet's internal decoys.
  • Bug fix: address wrong mass being returned by RTS fragment ion index searches in the 2026.01 rev. 0 release that did not take into account static modifications in the mass calculation. (Everything else was fine.)
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