Random biomass reaction with desired number of precursors

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Ehsan Zangene

Feb 7, 2023, 2:18:37 AM2/7/23
to COBRA Toolbox
Dear All,

I tailored some metabolic models based on iMAT, Recon2.v04, and an expression matrix using the COBRA toolbox built-in function createTissueSpecificModel. I did a few tests with them and everything worked fine, but now I need to demonstrate how the biomass reaction is helpful in answering my questions, therefore I need to create a same random biomass reaction for all models and redo the downstream experiments (then repeat this process in n iterations).
What are your ideas for such a purpose?
How can I create a random biomass reaction with the same magnitude as the actual biomass reaction in Recon2.v04 while keeping all metabolic modeling assumptions in mind?

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