Internet product "Melanoboost" claims to increase a skin tan 250% as applied to skin as a melanocyte stimulating hormone peptide. Melbourne based.

[Uhohinc]

https://www.melanoboost.com/pages/faqs

[Uhohinc]

With the introduction of peptides into skin products, there has been much interest about the difference between Melanoboost and tanning injections, most commonly known as Melanotan, Melanotan II or MT2.

There are distinct differences between Melanoboost and Melanotan.

Melanoboost Peptide Sun Tanning OilPeptide Based Tanning Oil
Firstly, an introduction to Melanoboost:



Melanoboost Peptide Sun Tanning Oil was created to increase tanning with a new, innovative TOPICAL peptide, that is safe and effective. This is what makes it so groundbreaking. The ingredients are topical, meaning unlike injections, they do not enter the bloodstream.

Melanoboost Peptide Complex is infused in a based of super food oils and is designed to work only in the areas you apply it, meaning it’s localised to the skin.
Our Peptide Complex is an a-MSH agonist peptide at MC1 receptor. It mimics the role of a-MSH (alpha - Melanin Stimulating Hormone), which is naturally occurring in our body. Upon mimicking the role of a-MSH, it stimulates the skin’s MC1 receptor. This receptor is directly responsible for controlling our tanning cells (melanocytes).

a-MSH is usually released in our bodies when exposed to UV light, however Melanoboost mimics it without the need for sun exposure, so can work indoors also. When it is used in conjunction with sun exposure, results are more rapid.

How Melanoboost differs from tanning injections:

Melanotan ll is an unlicensed and unregulated drug.

Delivered by subcutaneous injection, the drug stimulates the MC1 receptor (for tanning), however is said to also stimulate the MC2, 3, 4 and 5 receptors causing a number of adverse side effects which is why it has never received approval from any governmental drug regulatory bodies.
Melanotan Injections
Melanoboost is a safe and effective topically applied oil that stimulates the tanning receptor only (MC1R) and therefore has no adverse side effects.



Back to Melanoboost:

Melanoboost Peptide Complex can increase melanin levels by 250% (259% to be precise!)

Melanoboost is safe to use and will work it’s magic indoors as well as outdoors, with results being significantly more rapid when used in conjunction with short bursts of UV exposure.

We recommend taking a balanced approach to sun exposure, to maximise benefit and minimise risk. So always wear sunscreen when you’re spending time in the sun (on top of your Melanoboost when you’re wearing it).

Learn more about the super food oils, ingredients and technologies in Melanoboost Peptide Tanning Oil.

#MinimumSunMaximumTan #PeptideTanning #Melanoboost
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[Zero tolerance]

On the surface, and with limited medical knowledge, this concerns me. Combined with the inexplicable 25% drop in the stock price, I am petrified. Could you share your thoughts about this as a potential threat to sales? Thanks.

[Uhohinc]

I think they are not an effect on Clinuvel or it's stock price as can be determined now or probably not in the future. I would be surprised if the product works, and I think even from the info provided it does not reach any melanocortins. I think this will sour the public confidence in a Clinuvel topical transdermal when it is approved and presented initially.
But what they claim is right now a real easy technical possibility.

They could have a lab develop a melanocyte stimulating hormone under a molecular weight of 500 daltons that could have some "peptide" reach past some of the outer corneum and deeper to where the melanocytes reside. This is easy on mice skin but not on human skin. And they also could have used some skin penetration enhancing breakthrus in conjunction with their melanocyte stimulating hormone.

They really give no info out at all and do not address major claims. But then why should they write to skeptics or competitors or questions when their goal is a simplistic impulsive consumer to buy the result/story/drug. Oh wait, they never called it a drug.

Their lack of anyone of consequence understanding or caring to review the website as to the erroneous information that I have never seen anywhere that mcr2 is affecting in anyway thru msh is indicative of a level of technical in-sophistication for a most basic of the Mechanics of msh.

Their claim of melanotan not being approved..........what about their drug not being approved. The only melanocyte stimulating approved at least somewhere by any authority is Scenesse.

The dubious claim of a 250% increase in melanin and then clarified at 257 % is in no context. To what study. What's the baseline. What factors. In whom, how many, ?????
Human skin is different in all and different in different areas of skin. Sweating while laying on a beach is going to be affecting any lotion on face different than arms etc.
And most people whom put even nothing on the skin it can be claimed will have two and a half times more melanin at some given amount of time spent in sun.
And for the $49 you are at least buying the placebo effect.

As a sideline, I was at a Costco yesterday and noticed they are selling a bottle of Tumeric concentrate in capsules. On label it also indicated piperine. It is amazing how one can see how the abstracts has
come out and how quickly someone has commercialized the scientific breakout knowledge and danced past FDA with technicalities in foods and vitamins and nutrients to regulators.

Clinuvel most probable has no worry from Melanoboost jumping to market too soon, but there are going to be more like it and with probably much more efficacy to be a skin applied tanning lotion.

[Uhohinc]

That molecular weight should read molecular mass.

[nosuchth...@gmail.com]

Just read through their website FAQs and you will see that this is complete BS riding off the back of the communities minimal understanding of MSH.

[all4...@aol.com]

On Tuesday, February 14, 2017 at 1:56:21 PM UTC-6, nosuchth...@gmail.com wrote:
> Just read through their website FAQs and you will see that this is complete BS riding off the back of the communities minimal understanding of MSH.

A LOT OF people who are avid sun worshippers and care very much to get a suntan most likely do not even know what Melanin is, much less the action of Tyrosinase and also not know what Tyrosine is and what it has to do with Melanin and a suntan...so don't fault people for not being knowledgeable about how a suntan is obtained.