As most viruses are too small to be seen by a light microscope, sequencing is one of the main tools in virology to identify and study the virus.[11] Viral genomes can be based in DNA or RNA. RNA viruses are more time-sensitive for genome sequencing, as they degrade faster in clinical samples.[12] Traditional Sanger sequencing and next-generation sequencing are used to sequence viruses in basic and clinical research, as well as for the diagnosis of emerging viral infections, molecular epidemiology of viral pathogens, and drug-resistance testing. There are more than 2.3 million unique viral sequences in GenBank.[11] Recently, NGS has surpassed traditional Sanger as the most popular approach for generating viral genomes.[11]
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