APS 2016 - Focus session on Critical transitions in biological systems
March 14-18, 2016, Baltimore, MD, USA
Co-sponsored by: DBIO/GSNP
Division of Biological Physics/Statistical & Nonlinear Physics
When submitting, please select 3.1.18 or 4.1.23 for “sorting category”
Many biological processes (chronic disease onset, development and differentiation,
self-assembly, etc.) are reminiscent of phase transitions in a dynamic system:
Quantitative changes accumulate largely unnoticed until a critical threshold is reached,
which causes abrupt qualitative changes of the system. Understanding such nonlinear
behaviors is critical to dissect the multiple genetic/environmental factors that together
shape the genetic and physiological landscape underlying basic biological functions,
and to identify the key driving molecules.
In this focus session, we will bring together biophysicists, statistical physicists,
scientists studying nonlinear dynamic systems, as well as systems biologists. We will
discuss the current quantitative approaches to study the critical phase transitions in
several model biological systems; and how such studies have been applied to areas
including but not limited to: genetics of complex disease, driving network identification,
and molecular marker prediction.
We invite abstracts from quantitative scientists who have worked on critical transitions
in biological systems, as well as biologists who have a model system of critical
transition, or who think they have observed a critical-transition-like phenomenon in their
biological systems, and are interested to work with quantitative scientists to investigate
further.
Two invited speakers, listed below, have been confirmed. In addition, ~10 abstracts
will be selected for contributed talks.
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Luonan Chen, PhD
Key Laboratory of Systems Biology,
Institute of Biochemistry and Cell Biology,
Shanghai Institutes for Biological Sciences,
Chinese Academy of Sciences
Title: "Detecting early-warning signals of critical transitions for complex systems"
Xujing Wang, PhD
Systems Biology Center
National Heart, Lung, and Blood Institute (NHLBI),
National Institutes of Health (NIH)
Title: “Investigation of functional consequence of geometric phase transition in cellular
networks using the pancreatic islets as a model system”