Safely logging data to a file or SQLite database during heavy traffic

[Malcolm]

I've built a small CherryPy 3.2 application that's designed to log
data to file or a SQLite database.

What do I need to do (if anything) to make sure my writes to a regular
file on disk or to a SQLite database are atomic in nature when
multiple clients post data to my application simultaneously?

Do I need to use a Queue type data structure and then run a background
thread that monitors my Queue for data which it (and it alone) removes
and copies to the destination file or SQLite datatbase?

Thank you,
Malcolm