This should be possible with wspbus. You'd write your central
subscriber as a plugin. See for example the way the template tool &
plugin interact in Sylvain's app here:
https://bitbucket.org/Lawouach/twiseless/src
Looks like it is possible:
Subscriber side calls on the bus to get a new mako.Template instance
https://bitbucket.org/Lawouach/twiseless/src/d171fde9e454/lib/tool/template.py#cl-22
And service responds here:
https://bitbucket.org/Lawouach/twiseless/src/d171fde9e454/lib/plugin/template.py#cl-40
Very nice and much appreciation for pointing this repository out.