Handbook Of Pharmaceutical Excipients Edisi 6 Pdf
Zebedeo Konig
The Handbook of Pharmaceutical Excipients is internationally recognised as the worlds most authoritative source of information on pharmaceutical excipients. It provides you with a one stop resource when researching an excipient for use. The 400+ monographs are also thoroughly cross referenced and indexed to allow their identification by chemical, non proprietary or trade names. Extensive content updates in the new edition include: - Over 420 fully referenced excipient monographs, many including IR, Raman, and NIR spectra - 13 new monographs including several amino acids and hydrated silicon dioxide - 250 existing monographs reviewed - New chapters include excipient selection for orally inhaled and injectable formulations Order your copy today and: Get the full picture on excipients - all the information you need on the physical properties of excipients Save research time - each monograph contains everything you need to ensure the correct excipient is selected Ease of use - monographs are thoroughly cross-referenced and indexed so that excipients can easily be identified by either a chemical, a non-proprietary or a trade name Get up to speed quickly on unfamiliar areas with educational chapters on topics such as the characteristics of excipients in formulations
CONTENTS:
Table of Contents
New Formulation Considerations and Related Information chapters on:
Functional Categories of Pharmaceutical Excipients
Pharmaceutical Excipients in Pediatric Formulations
The Selection of Excipients for Oral Solid Dosage Forms
The Selection of Excipients for Injectable Formulations
Formulation Considerations for Orally Inhaled Dosage Forms
Reactive Components in Pharmaceutical Excipients
Biological Effects of Pharmaceutical Excipients
The Use of Counter-ions and Co-formers in the Creation of Salt and Co-crystal Forms of Active Pharmaceutical Ingredients (APIs)
Over 400 Monographs benefiting from a standardized, easy-to-use template including:
pharmacopoeial information from the UK, Europe, Japan and the United States
non-proprietary names and synonyms
chemical name and structure, CAS Registry number, empirical formula, molecular weight
functional category, applications and incompatibilities
material description and typical excipient properties
safety, stability, storage and handling information
method of drug manufacture
related substances
primary references
editorial comments
author details and revision date
Appendices
Suppliers directory
List of Monographs by Functional Category
List of Related Substances
List of Excipients by E number
List of Excipients by EINECS number
List of Excipients by CAS number
Pharmaceutical Excipients Assessed by the FDA Select Committee on GRAS Substances (SCOGS)
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Introduction: Starch is one of the ingredients that has many benefits, including in the pharmaceutical field, especially as a pharmaceutical excipient in pharmaceutical formulations.
Methods: The characteristics of the perceived banana starch can be said to be comparable to that of corn starch so that it is expected to be used as a source of starch which can be used as a pharmaceutical excipient. The starch of isolated banana fruit was used as a filler, binder, and crusher in the wet granulation method tablet formulations with concentrations of 2%, 3%, and 5%.
Results: The physicochemical characteristics of starch isolated from banana fruit are considered to meet the requirements of pharmaceutical excipients required in the Handbook of Pharmaceutical Excipients 6th edition and the United States Pharmacopeia 32nd edition.
The International Pharmacopoeia (Ph. Int.) is published by WHO with the aim to provide specifications and test methods for priority medicines of major public health importance, for example listed in the WHO Model list of Essential Medicines, recommended by specific WHO disease programmes, as well as medicines for children. Priority is also given to medicines evaluated by the Medicines Prequalification Programme. Access to priority medicines shall also be increased by global harmonization of quality specifications for selected pharmaceutical products, excipients and dosage forms. The activities related to Ph.Int. are an essential element in the overall quality control and assurance of pharmaceuticals contributing to the safety and efficacy of medicines.
Objective: Fast-disintegrating tablets are a pharmaceutical preparation that is rapidly being developed because they can dissolve in the oral cavity
without chewing and without additional water support. The type of dissolver is a crucial component in fast-disintegrating tablets. Maltodextrin and
pregelatinized cassava starch (PPS) are excipients that can be used as dissolvers. This study aimed to formulate fast-disintegrating tablets using a
combination of maltodextrin dextrose equivalent (DE) 10-15 and PPS in various concentrations as excipients.
Methods: The cassava starch classified as PPS was obtained. PPS was then mixed with maltodextrin DE 10-15 to create fast-disintegrating tablets
using the wet granulation method.
Results: Tablet evaluation showed that formula F containing 40% maltodextrin DE 10-15 and 10% PPS was the most effective of the proposed fastdisintegrating
tablets.
Conclusions: Formula F has a hardness of 3.39 kp, 0.74% friability, a wetting time of 7.87 seconds, and a dissolve time of 38.55 seconds.