Below is an example that works for me with wheels 1.1.8 and apache 2.4 on linux. I am replacing servername and docroot with placeholders.
You'll need FollowSymLinks enabled if you plan to keep the Rewrite rules inside the directory block. Also you may need to set RewriteEngine On depending on what context you are placing the rules in (I do that in the example below as well).
This example does not contain everything I would typically include for a given vhost; this is just to illustrate the minimum required to enable wheels rewrites.
DocumentRoot /apache/public/myapp
<Directory /apache/public/myapp>
Options FollowSymLinks
Require All Granted
RewriteEngine On