CF Lung Island Biogeography piece

[Katrine Whiteson]

Hi Guys,

Hope you are settling back into life where you don't get to go hiking every afternoon...

Thanks for brainstorming this opinion piece with me, in response to the oral "contamination" issue. I am considering making this an unsolicited commentary to ISME (details below).

I wrote a draft, using the Island Biogeography ideas we discussed as a framework, with the hope that people will come away unable to ignore the undeniable truth that oral and lung communities are in constant contact with each other.  I did present the beginning of a re-analysis of Pradeep Singh's data without confronting the fact that our conclusions are actually quite opposite so that it does not have a confrontational flavor. Suggestions are very welcome!

To make edits, you can find the draft in two ways:

1) I have posted this in a shared google document in our CFTelluride folder that all of you should be able to access and edit:

https://docs.google.com/document/d/1-m3tAOPZlGXvfH9pmmzumxuPxvvGitqlyD8F2-Zq_50/edit

Google docs keep track of revision histories (look in File > Revision History) and allow for comments too; I will keep my updates in this document as well. Please give comments by next Friday, August 23rd, and add your name to the list at the top if you are contributing.

2) I am attaching a pdf and a word doc here too in case some of you prefer that, you can also email me comments. I will be out of town from August 16th-22nd.

:)

Katrine

[Jonathan Kirk Harris]

Katrine,
Excellent start. I added a few comments on my first pass through the document and a few additional thoughts at the end. I'll have more time to look at this next week when I'm back in Colorado. Thanks for getting a draft out to everyone.

Kirk
________________________________________
From: cftellu...@googlegroups.com [cftellu...@googlegroups.com] On Behalf Of Katrine Whiteson [katrine...@gmail.com]
Sent: Tuesday, August 13, 2013 10:11 AM
To: cftellu...@googlegroups.com
Subject: CF Lung Island Biogeography piece

[Jim Sullivan]

Hi Katrine,

Very nice.

I added a few comments on top of Kirks' and tried to generalize the intro a bit more. Feel free to take or leave what you wish.

Cheers,

Jim

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[brandie wagner]

Katrine,

Thanks so much for taking the lead on this, I think it will be an important
contribution. I have added a few comments and suggestions as well.

Best,
Brandie

[Paul B Rainey]

dear Katrine et al

I enjoyed reading this through.  I think this has legs.  My two cents worth would be to pick up on a suggestion that Jim made and that would be to begin the article from a more general and island biogeograhical perspective.  Lay out the concepts in general terms, starting with the original island biogeography ideas (which were strictly ecological) and then to expand this in light of recent research to the point where we introduce the idea that ecology affects evolution and that the theory of island biogeography must also encompass evolution (as has been argued and shown).  Only once this is done would I introduce the human host as an island and, more specifically the CF lung (as island).  I think this would provide a much better framework within which the microbial data will sit very comfortably.  I think we'd also be in a better position to use the principals laid out in the introduction to explain some of the patterns of diversity noted within and between the microbiome of lungs from different patients.  

Best wishes to you all

Paul

[mfip mfip]

Soory Guys,

I forgot to shake my Gmail box from August: too busy and please use the following address to contact me: laurence...@pasteur-lille.fr !

 

Very nice text and exchanges.

Many thanks Katherine for having takien the lead on this important point.

I have added few suggestions.

Cheers

Laurence

 

2013/8/25 Paul B Rainey <paulb...@gmail.com>

[mfip mfip]

Here is the good message with the document!

Sorry Guys,

I forgot to look my Gmail box from August: too busy and please use the following address to contact me:laurence...@pasteur-lille.fr !

 Very nice text and exchanges.

Many thanks Katherine for having taken the lead on this important point.

I have added few suggestions.

Cheers

Laurence

2013/9/19 mfip mfip <mfip.d...@gmail.com>