Evasion of apoptosis is a hallmark of tumorigenesis and a recognised cause of multidrug resistance. Over the last decade, insights into how apoptosis might be exploited in non-small cell lung cancer (NSCLC) and how cancer therapeutics might be used to engage apoptotic signalling in a personalised manner have changed markedly. We are now in the wake of a paradigm shift in stratified therapeutic approaches related to NSCLC. At the heart of this shift in thinking is the emerging knowledge that even the most drug-resistant cancers exhibit a functional death pathway and, critically, that this pathway can be efficiently engaged, leading to clinical benefit. This review will summarise current knowledge of mitochondrial apoptotic pathway dysfunction in NSCLC and how the next generation of targeted therapeutics might be used to exploit deficiencies in apoptotic signalling in a personalised manner to improve clinical outcome and predict therapeutic benefit.
Just like on iOS, the alarm clock lets you wake up to your favorite Pandora music. When the alarm goes off, your music will begin to play with album art scrolling in the background, and you can choose to snooze, keep listening to your music, or turn off the alarm simply by tapping the song title or artist name.
In the wake of increasing globalization over the past fifty years, international criminal law has transformed from a toothless shadow into a concrete reality; the International Criminal Court is the most recent and impressive institutional accomplishment. Unfortunately, international criminal law has enjoyed this progress on the heels of increasingly horrific international crimes. International adjudicatory institutions have taken many forms and the sentences they deliver have varied widely. In Atrocity, Punishment, and International Law, Mark Drumbl reviews the strides made in international criminal law from the Nuremberg trials through present-day trials, particularly those related to the crimes committed in Rwanda and Yugoslavia. In doing so, Drumbl offers one of the most comprehensive assessments of the role of punishment in international criminal law. In this Review, I detail Drumbl's primary themes and acknowledge the book's numerous and notable contributions to the field of international criminal law. I then argue that a natural extension of Drumbl's theory of cosmopolitan pluralism is the use of religious institutions as vehicles of rehabilitation and restoration for communities fractured by mass atrocity.
At the time, Mr Thomas, the data tsar who, in the wake of the crisis, has spent the past few weeks issuing warnings about the danger of ID fraud on the internet, described the Government's blunder as "unprecedented and deeply disturbing".
"EU Member States have been aggressively competing in a race to the bottom on corporate income taxation. The current rules to fight harmful tax practices in the EU, as enshrined in the EU Code of Conduct on Business Taxation, are outdated. The Code of Conduct Group is one of the most secretive groups in EU decision making. It's time to re-define what harmful tax practices are and that's why this report offers Member States a new basis through which tax competition can effectively be tackled. The report also includes tax competition for high net worth individuals, which is clearly essential in the wake of the Pandora Papers. A tax race to the bottom brings everyone down, it undermines our welfare, SMEs and public services, and weakens trust in democratic institutions. The only true winners of a race to the bottom are multinationals and the global financial elite.