I'm not sure if I can be of much help, but I've been using cctiddly
(from the first version of cct by coolcold, to 1.7.6 and 1.8.5 by
Simon McManus) for few years now.
All I can say is that - yes, because of mysql and PHP, this
tw-variant is the only viable alternative for me. I have a
"production" cctiddly (1.8.5) with more than 8k records (tiddlers)
that is used by some 10-20 people (it's an ISMS according to *ISO
27001) and I think I'm hitting its limits - performance-,
maintenance-wise.
The most important problem, probably due to its size, is unreliability
of the saving process (changes may not get saved into the database,
without warning) and also creation of duplicates (same titles for more
tiddlers) which will make some tiddlers "disappear" on the client side
while in the database back-end they still exist.
Over the years of usage I've learnt how to spot some of these issues
and how to (manually) fix them. But with growing number of users it is
difficult it "teach" them all the workarounds. I still refer to my
cctiddly as a "prototype" and I warn my users to check twice the work
they did in it.
Because of all this I've tried to move on to TiddlyWeb, but without
success. For me TiddlyWeb seems to have a much more difficult setup
(python and other issues) and above all, rather different philosophy
of working with "records".
For now I'm sticking to cctiddly, even though one day these cctiddly
workspaces I've created for ISMS, risk assessment and threat modelling
may get converted into native web-based applications. As soon as I
find a better solution.
Of course the most beatiful part of tiddlywiki is working with tags
and creating database-like relationships ad-hoc, via web browser. The
flexibility it gives you is limitless and that's the only reason I've
stayed with cctiddly for so long.
VL
*just these days we have successfully finished the certification
process for ISO/IEC 27001
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VL