Question re: cell line data

[Chen, Hui-Zi]

Dear cBioportal Group,

 

I am hoping you can help reconcile some data for me.

 

I have been trying to find small cell lung cancer cell lines with inactivating KMT2C mutations.

 

I have accessed 2 datasets: CCLE (Broad, 2019) and CCLE (Broad, Nat Rev cancer 2025). I presume there’s a high degree of overlap in the samples that are analyzed between the two datasets.

 

From the first Broad 2019 dataset, the following 2 cell lines showed non-sense mutations in KMT2C: COLO-668 and DMS454

 

However, I am unable to find KMT2C mutations in these two cell lines from the 2025 dataset (have crossed referenced with DepMap as well).

 

Are you able to help clarify which dataset is correct with regards to the KMT2C mutations, as this will be important for the experiments that we are planning ahead for.

 

Thanks so much for your assistance!

Huizi Chen

 

Huizi Chen, MD PhD

Assistant Professor

Division of Hematology & Oncology

Department of Medicine

Medical College of Wisconsin

Milwaukee, WI 53226