/ln?q= gene linkout failing with "Too Many Requests"

[Kacey]

Hi all,

We run a clinical variant interpretation tool that links out to cBioPortal per gene via https://www.cbioportal.org/ln?q=<GENE>. This has been working reliably for a while, but it's now failing to load, the browser Network tab shows a wave of 429 Too Many Requests errors and the page never finishes rendering.

From digging in, it looks like the default cross-cancer study list behind /ln has grown to roughly 241 public studies, and a case_set_id=all query across that full list fires enough parallel per-study fetches, one per study per profile type (mutations, cna, gistic, structural variants), to trip rate limiting before the page can finish rendering.

As a comparison point: a scoped query against a single study with a named case set loads fine, e.g.
https://www.cbioportal.org/results/oncoprint?cancer_study_list=msk_chord_2024&Z_SCORE_THRESHOLD=2.0&RPPA_SCORE_THRESHOLD=2.0&profileFilter=mutations,structural_variants,cna&case_set_id=msk_chord_2024_cnaseq&gene_list=BRAF&geneset_list=%20&tab_index=tab_visualize&Action=Submit

But a query spanning the full public study list with case_set_id=all does not.

/ln is documented as a way to link to a gene query without specifying a study, so I wanted to flag this in case other integrations are hitting the same thing. Is this a known issue, and is there a recommended workaround on our end, or is this something on cBioPortal's side, e.g. curating the default study list, or throttling the per-study fetches?

Happy to share network tab screenshots or more detail if useful.

Thanks,
Kacey

[de Bruijn, Ino]

Hi Kacey,

This should be fixed now. Apologies, we introduced more rate limiting due to the increase of agent traffic but it broke this functionality

Let us know if you still experience any issues

Best wishes,

Ino

From: cbiop...@googlegroups.com <cbiop...@googlegroups.com> on behalf of Kacey <kacey...@gmail.com>
Date: Monday, August 10, 2026 at 10:28 AM
To: cBioPortal for Cancer Genomics Discussion Group <cbiop...@googlegroups.com>
Subject: [EXTERNAL] [cbioportal] /ln?q= gene linkout failing with "Too Many Requests"

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