one allele present?

[Arno Greenleaf, Ph.D.]

Hello-

I love your cbioportal ! It is extremely useful and easy to use.

I have one question:  when a mutation in a gene is listed, does that imply there is not also a "WT" allele present?  For example, searching for PTEN mutations, and looking in the Cancer Cell Line Encyclopedia results, I see that PTEN has a nonsense mutation (R233*).  Is there also a non-mutant allele present?

Thanks.

Arno Greenleaf 

Arno Greenleaf, PhD

Department of Biochemistry

Duke University Medical Center

213 Research Drive, 0034 CARL Building

Durham, NC 27710

919-684-4034

ar...@duke.edu