MetaboList - July 2016

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Muñoz Pinedo, Cristina

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Aug 5, 2016, 12:28:29 PM8/5/16

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Have a nice summer,

regards,

Cristina

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Diet/obesity and Cancer

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Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

Stefano Di Biase, Changhan Lee, Sebastian Brandhorst, Brianna Manes, Roberta Buono, Chia-Wei Cheng, Mafalda Cacciottolo, Alejandro Martin-Montalvo, Rafael de Cabo, Min Wei, Todd E. Morgan, Valter D. Longo

http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30265-3

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Federico Pietrocola, Jonathan Pol, Erika Vacchelli, Shuan Rao, David P. Enot, Elisa E. Baracco, Sarah Levesque, Francesca Castoldi, Nicolas Jacquelot, Takahiro Yamazaki, Laura Senovilla, Guillermo Marino, Fernando Aranda, Sylvère Durand, Valentina Sica, Alexis Chery, Sylvie Lachkar, Verena Sigl, Norma Bloy, Aitziber Buque, Simonetta Falzoni, Bernhard Ryffel, Lionel Apetoh, Francesco Di Virgilio, Frank Madeo, Maria Chiara Maiuri, Laurence Zitvogel, Beth Levine, Josef M. Penninger, Guido Kroemer

http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30221-5

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

Joao Incio, Hao Liu, Priya Suboj, Shan M. Chin, Ivy X. Chen, Matthias Pinter, Mei R. Ng, Hadi T. Nia, Jelena Grahovac, Shannon Kao, Suboj Babykutty, Yuhui Huang, Keehoon Jung, Nuh N. Rahbari, Xiaoxing Han, Vikash P. Chauhan, John D. Martin, Julia Kahn, Peigen Huang, Vikram Desphande, James Michaelson, Theodoros P. Michelakos, Cristina R. Ferrone, Raquel Soares, Yves Boucher, Dai Fukumura, and Rakesh K. Jain

http://cancerdiscovery.aacrjournals.org/content/6/8/852.abstract?etoc

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Glycolytic enzymes

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Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

Andrea J. Wolf, Christopher N. Reyes, Wenbin Liang, Courtney Becker, Kenichi Shimada, Matthew L. Wheeler, Hee Cheol Cho, Narcis I. Popescu, K. Mark Coggeshall, Moshe Arditi, David M. Underhill

http://www.cell.com/cell/fulltext/S0092-8674(16)30723-1

Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma

Hyun Gyu Lee, Hyemi Kim, Taekwon Son, Youngtae Jeong, Seung Up Kim, Seung Myung Dong, Young Nyun Park, Jong Doo Lee, Jae Myun Lee, and Jeon Han Park

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=9723

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Lipid metabolism

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SREBP regulates the expression and metabolic functions of wild-type and oncogenic IDH1

Stéphane J.H. Ricoult, Christian C. Dibble, John M. Asara and Brendan D. Manning

http://mcb.asm.org/content/early/2016/06/21/MCB.00163-16.abstract

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

Xue Gao, Shu-Hai Lin, Feng Ren, Jin-Tao Li, Jia-Jia Chen, Chuan-Bo Yao, Hong-Bin Yang, Shu-Xia Jiang, Guo-Quan Yan, Di Wang, Yi Wang, Ying Liu, Zongwei Cai, Ying-Ying Xu, Jing Chen, Wenqiang Yu, Peng-Yuan Yang and Qun-Ying Lei

http://www.nature.com/ncomms/2016/160630/ncomms11960/full/ncomms11960.html

TAK1 regulates hepatic lipid homeostasis through SREBP

S Morioka, K Sai, E Omori, Y Ikeda, K Matsumoto and J Ninomiya-Tsuji

http://www.nature.com/onc/journal/v35/n29/abs/onc2015453a.html

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Glutamine metabolism

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Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4

Glenn Marsboom, Guo-Fang Zhang, Nicole Pohl-Avila, Yanmin Zhang, Yang Yuan, Hojin Kang, Bo Hao, Henri Brunengraber, Asrar B. Malik, Jalees Rehman

http://www.cell.com/cell-reports/abstract/S2211-1247(16)30702-1

Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax

R Bajpai, S M Matulis, C Wei, A K Nooka, H E Von Hollen, S Lonial, L H Boise and M Shanmugam

http://www.nature.com/onc/journal/v35/n30/abs/onc2015464a.html

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Marina Bolzoni, Martina Chiu, Fabrizio Accardi, Rosanna Vescovini, Irma Airoldi, Paola Storti, Katia Todoerti, Luca Agnelli, Gabriele Missale, Roberta Andreoli, Massimiliano G. Bianchi, Manfredi Allegri, Amelia Barilli, Francesco Nicolini, Albertina Cavalli, Federica Costa, Valentina Marchica, Denise Toscani, Cristina Mancini, Eugenia Martella, Valeria Dall’Asta, Gaetano Donofrio, Franco Aversa, Ovidio Bussolati, and Nicola Giuliani

http://bloodjournal.org/content/128/5/667.abstract?etoc

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Nucleotides, mitochondrial metabolism

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Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

Ashish Juvekar, Hai Hu, Sina Yadegarynia, Costas A. Lyssiotis, Soumya Ullas, Evan C. Lien, Gary Bellinger, Jaekyoung Son, Rosanna C. Hok, Pankaj Seth, Michele B. Daly, Baek Kim, Ralph Scully, John M. Asara, Lewis C. Cantley, and Gerburg M. Wulf

http://www.pnas.org/content/113/30/E4338.abstract.html?etoc

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology

Alexander Hahn, Kristian Parey, Maike Bublitz, Deryck J. Mills, Volker Zickermann, Janet Vonck, Werner Kühlbrandt, Thomas Meier

http://www.cell.com/molecular-cell/abstract/S1097-2765(16)30223-4

ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells is Independent of the Adenine Nucleotide Translocator

Eduardo N. Maldonado, David N. DeHart, Jyoti Patnaik, Sandra C. Klatt, Monika Beck Gooz, and John J. Lemasters

http://www.jbc.org/content/early/2016/07/25/jbc.M116.734814.abstract

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Hypoxia

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PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

Robert S. Banh, Caterina Iorio, Richard Marcotte, Yang Xu, Dan Cojocari,Anas Abdel Rahman, Judy Pawling, Wei Zhang, Ankit Sinha, Christopher M. Rose, Marta Isasa, Shuang Zhang, Ronald Wu, Carl Virtanen, Toshiaki Hitomi, Toshiyuki Habu, Sachdev S. Sidhu, Akio Koizumi, Sarah E. Wilkins, Thomas Kislinger, Steven P. Gygi, Christopher J. Schofield, James W. Dennis, Bradly G. Wouters & Benjamin G. Neel

http://www.nature.com/ncb/journal/v18/n7/full/ncb3376.html

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

Wenxian Wu, Chunxia Lin, Keng Wu, Lei Jiang, Xiaojing Wang, Wen Li, Haixia Zhuang, Xingliang Zhang, Hao Chen, Shupeng Li, Yue Yang, Yue Lu, Jingjing Wang, Runzhi Zhu, Liangqing Zhang, Senfang Sui, Ning Tan, Bin Zhao, Jingjing Zhang, Longxuan Li, and Du Feng

http://EMBOJ.embopress.org/content/35/13/1368?etoc

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Starvation / nutrient sensing

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Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

Robert A. Saxton, Lynne Chantranupong, Kevin E. Knockenhauer, Thomas U. Schwartz, David M. Sabatini

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19079.html

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

Jae Ho Seo, Dayana B. Rivadeneira, M. Cecilia Caino, Young Chan Chae, David W. Speicher, Hsin-Yao Tang, Valentina Vaira, Silvano Bosari, Alessandro Palleschi, Paolo Rampini, Andrew V. Kossenkov, Lucia R. Languino, Dario C. Altieri

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002507

Changes in O-GlcNAc homeostasis activate the p53 pathway in ovarian cancer cells

Rafaela Muniz de Queiroz, Rashna Madan, Jeremy Chien, Wagner Barbosa Dias, and Chad Slawson

http://www.jbc.org/content/early/2016/07/11/jbc.M116.734533.abstract

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AMPK/mTOR

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AMP-activated protein kinase upregulates MAP kinase interacting serine/threonine kinase 1a-dependent phosphorylation of eukaryotic translation initiation factor 4E

Xiaoqing Zhu, Vivian Dahlmans, Ramon Thali, Christian Preisinger, Benoit Viollet, J. Willem Voncken, and Dietbert Neumann

http://www.jbc.org/content/early/2016/07/13/jbc.C116.740498.abstract

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N-terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis

Reinhard Zech, Stephan Kiontke, Uwe Mueller, Andrea Oeckinghaus, and Daniel Kümmel

http://www.jbc.org/content/early/2016/08/04/jbc.M116.732446.abstract

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Miscellaneous

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Glycolytic regulation of cell rearrangement in angiogenesis

Bert Cruys, Brian W. Wong, Anna Kuchnio, Dries Verdegem, Anna Rita Cantelmo, Lena-Christin Conradi, Saar Vandekeere, Ann Bouché, Ivo Cornelissen, Stefan Vinckier, Roeland M. H. Merks, Elisabetta Dejana, Holger Gerhardt, Mieke Dewerchin, Katie Bentley and Peter Carmeliet

http://www.nature.com/ncomms/2016/160720/ncomms12240/full/ncomms12240.html

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

Haobin Ye, Biniam Adane, Nabilah Khan, Timothy Sullivan, Mohammad Minhajuddin, Maura Gasparetto, Brett Stevens, Shanshan Pei, Marlene Balys, John M. Ashton, Dwight J. Klemm, Carolien M. Woolthuis, Alec W. Stranahan, Christopher Y. Park, Craig T. Jordan

http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)30151-5

Deciphering the Duality of Clock and Growth Metabolism in a Cell Autonomous System Using NMR Profiling of the Secretome

Arjun Sengupta, Saikumari Y. Krishnaiah , Seth Rhoades , Jacqueline Growe , Barry Slaff , Anand Venkataraman, Anthony O. Olarerin-George , Chi Van Dang , John B. Hogenesch and Aalim M. Weljie

http://www.mdpi.com/2218-1989/6/3/23

NHX-5, an endosomal Na+/H+ exchanger, is associated with metformin action

Jeongho Kim, Hye-Yeon Lee, Jheesoo Ahn, Moonjung Hyun, Inhwan Lee, Kyung-Jin Min, and Young-Jai You

http://www.jbc.org/content/early/2016/07/19/jbc.C116.744037.abstract

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Reviews

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Mitochondria and Cancer

Sejal Vyas, Elma Zaganjor, Marcia C. Haigis

http://www.cell.com/cell/abstract/S0092-8674(16)30908-4

Role of chaperone-mediated autophagy in metabolism

Inmaculada Tasset and Ana Maria Cuervo