MetaboList - November 2015

12 views

Skip to first unread message

Muñoz Pinedo, Cristina

unread,

Dec 2, 2015, 6:05:03 AM12/2/15

to cancerme...@googlegroups.com, Afshin, Brugge, Joan Siefert, Celeste Simon, Christian Frezza, Danial, David Guertin, Issam, Jochen Prehn, John O'Neill, K Vousden, Lampidis, Theodore J, Marja, martac...@ub.edu, mel...@uniroma2.it, Mike, Moscat, Nada Kalaany, Narita, ndjo...@cnio.es, Peter V, Priya, Richard Knight, Ruoning, Sally, Serrano, Sir John Walker, Tak Mak, Wei-Xing Zong, Yang

Regards,

Cristina

-------------------------------

Cancer metabolism

-------------------------------

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

Shiran Rabinovich, Lital Adler, Keren Yizhak, Alona Sarver, Alon Silberman, Shani Agron, Noa Stettner, Qin Sun, Alexander Brandis, Daniel Helbling, Stanley Korman, Shalev Itzkovitz, David Dimmock, Igor Ulitsky, Sandesh C. S. Nagamani, Eytan Ruppin & Ayelet Erez

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature15529.html

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth

Emily D. Montal, Ruby Dewi, Kavita Bhalla, Lihui Ou, Bor Jang Hwang, Ashley E. Ropell, Chris Gordon, Wan-Ju Liu, Ralph J. DeBerardinis, Jessica Sudderth, William Twaddel, Laszlo G. Boros, Kenneth R. Shroyer, Sekhar Duraisamy, Ronny Drapkin, R. Scott Powers, Jason M. Rohde, Matthew B. Boxer, Kwok-Kin Wong, Geoffrey D. Girnun

http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00764-9

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

Ruiting Lin, Shannon Elf, Changliang Shan, Hee-Bum Kang, Quanjiang Ji, Lu Zhou, Taro Hitosugi, Liang Zhang, Shuai Zhang, Jae Ho Seo, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Jessica Sudderth, Lei Jiang, Matthew Mitsche, Ralph J. DeBerardinis, Shaoxiong Wu, Yuancheng Li, Hui Mao, Peng R. Chen, Dongsheng Wang, Georgia Zhuo Chen, Selwyn J. Hurwitz, Sagar Lonial, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Qunying Lei, Daniel J. Brat, Keqiang Ye, Titus J. Boggon, Chuan He, Sumin Kang, Jun Fan, & Jing Chen

http://www.nature.com/ncb/journal/v17/n11/full/ncb3255.html

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

Chunming Cheng, Peng Ru, Feng Geng, Junfeng Liu, Ji Young Yoo, Xiaoning Wu, Xiang Cheng, Vanessa Euthine, Peng Hu, Jeffrey Yunhua Guo, Etienne Lefai, Balveen Kaur, Axel Nohturfft, Jianjie Ma, Arnab Chakravarti, Deliang Guo

http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00352-9

Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations

Frank Rolfs, Marcel Huber, Andreas Kuehne, Stefan Kramer, Eric Haertel, Sukalp Muzumdar, Johanna Wagner, Yasmine Tanner, Friederike Böhm, Sigrun Smola, Nicola Zamboni, Mitchell P. Levesque, Reinhard Dummer, Hans-Dietmar Beer, Daniel Hohl, Sabine Werner, and Matthias Schäfer

http://cancerres.aacrjournals.org/content/75/22/4817.abstract?etoc

Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer

Shalini Jain, Xiao Wang, Chia-Chi Chang, Catherine Ibarra-Drendall, Hai Wang, Qingling Zhang, Samuel W. Brady, Ping Li, Hong Zhao, Jessica Dobbs,Matt Kyrish, Tomasz S. Tkaczyk, Adrian Ambrose, Christopher Sistrunk, Banu K. Arun, Rebecca Richards-Kortum, Wei Jia, Victoria L. Seewaldt, and Dihua Yu

http://cancerres.aacrjournals.org/content/75/22/4863.abstract?etoc

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

Charlotte Lussey-Lepoutre, Kate E. R. Hollinshead, Christian Ludwig, Mélanie Menara, Aurélie Morin, Luis-Jaime Castro-Vega, Seth J. Parker, Maxime Janin, Cosimo Martinelli, Chris Ottolenghi, Christian Metallo, Anne-Paule Gimenez-Roqueplo, Judith Favier and Daniel A. Tennant

http://www.nature.com/ncomms/2015/151102/ncomms9784/full/ncomms9784.html

The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.

Choe M, Brusgard JL, Chumsri S, Bhandary L, Zhao XF, Lu S, Goloubeva OG, Polster BM, Fiskum GM, Girnun GD, Kim MS, Passaniti A

http://onlinelibrary.wiley.com/doi/10.1002/jcb.25171/abstract

Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5

Liraz Levi, Zeneng Wang, Mary Kathryn Doud, Stanley L. Hazen and Noa Noy

http://www.nature.com/ncomms/2015/151123/ncomms9794/full/ncomms9794.html

-------------------------------------

Glutamine synthethase

-------------------------------------

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

Saverio Tardito, Anaïs Oudin, Shafiq U. Ahmed, Fred Fack, Olivier Keunen, Liang Zheng, Hrvoje Miletic, Per Øystein Sakariassen, Adam Weinstock, Allon Wagner, Susan L. Lindsay, Andreas K. Hock, Susan C. Barnett, Eytan Ruppin, Svein Harald Mørkve, Morten Lund-Johansen, Anthony J. Chalmers, Rolf Bjerkvig, Simone P. Niclou, Eyal Gottlieb

http://www.nature.com/ncb/journal/v17/n12/full/ncb3272.html

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation

Alex J. Bott, I-Chen Peng, Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokowski, Wenyun Lu, Ji-An Pan, Scott Powers, Joshua Rabinowitz, Maria Hatzoglou, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, Wei-Xing Zong

http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00482-9

---------------------------------

Anti-metabolic drugs

---------------------------------

Heightening Energetic Stress Selectively Targets LKB1-Deficient Non–Small Cell Lung Cancers

Milica Momcilovic, Robert McMickle, Evan Abt, Atsuko Seki, Sarah A. Simko, Clara Magyar, David B. Stout, Michael C. Fishbein, Tonya C. Walser, Steven M. Dubinett, and David B. Shackelford

http://cancerres.aacrjournals.org/content/75/22/4910.abstract?etoc

Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198

Remco J. Molenaar, Dennis Botman, Myrthe A. Smits, Vashendriya V. Hira, Sanne A. van Lith, Jan Stap, Peter Henneman, Mohammed Khurshed, Krissie Lenting, Adri N. Mul, Dionysia Dimitrakopoulou, Cornelis M. van Drunen, Ron A. Hoebe, Tomas Radivoyevitch, Johanna W. Wilmink, Jaroslaw P. Maciejewski, W. Peter Vandertop, William P. Leenders, Fonnet E. Bleeker, and Cornelis J. van Noorden

http://cancerres.aacrjournals.org/content/75/22/4790.abstract?etoc

JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification

Wenyi Sun, Zuoquan Xie, Yifu Liu, Dan Zhao, Zhixiang Wu, Dadong Zhang, Hao Lv, Shuai Tang, Nan Jin, Hualiang Jiang, Minjia Tan, Jian Ding, ChengLuo, Jian Li, Min Huang, and Meiyu Geng

http://cancerres.aacrjournals.org/content/75/22/4923.abstract?etoc

Inhibition of mitochondrial complex II by the anti-cancer agent lonidamine

Lili Guo, Alexander A. Shestov, Andrew J. Worth, Kavindra Nath, David S. Nelson, Dennis B. Leeper, Jerry D. Glickson, and Ian A. Blair

http://www.jbc.org/content/early/2015/10/31/jbc.M115.697516.abstract

-------------------

Hypoxia

-------------------

PI3K–mTORC2 but not PI3K–mTORC1 Regulates Transcription of HIF2A/EPAS1 and Vascularization in Neuroblastoma

Sofie Mohlin, Arash Hamidian, Kristoffer von Stedingk, Esther Bridges, Caroline Wigerup, Daniel Bexell, and Sven Påhlman

http://cancerres.aacrjournals.org/content/75/21/4617.abstract?etoc

Suppression of miR‐199a maturation by HuR is crucial for hypoxia‐induced glycolytic switch in hepatocellular carcinoma

Ling‐Fei Zhang, Jia‐Tao Lou, Ming‐Hua Lu, Chunfang Gao, Shuang Zhao, BiaoLi, Sheng Liang, Yong Li, Dangsheng Li, and Mo‐Fang Liu

http://EMBOJ.embopress.org/content/34/21/2671?etoc

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

Huimin Zhang, Haiquan Lu, Lisha Xiang, John W. Bullen, Chuanzhao Zhang, Debangshu Samanta, Daniele M. Gilkes, Jianjun He, and Gregg L. Semenza

http://www.pnas.org/content/112/45/E6215.abstract.html?etoc

--------------------------------------------

Nutrient sensing / mTOR

--------------------------------------------

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten,Ming O. Li, Constantinos Koumenis and Craig B. Thompson

http://genesdev.cshlp.org/content/29/22/2331.abstract

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

Samantha J. Mentch, Mahya Mehrmohamadi, Lei Huang, Xiaojing Liu, Diwakar Gupta, Dwight Mattocks, Paola Gómez Padilla, Gene Ables, Marcas M. Bamman, Anna E. Thalacker-Mercer, Sailendra N. Nichenametla, Jason W. Locasale

http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00457-X

Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation

Yuji Tanaka, Hirohisa Yano, Sachiko Ogasawara, Sho-ichi Yoshioka, Hiromi Imamura, Kengo Okamoto, and Makoto Tsuneoka

http://mcb.asm.org/content/35/24/4170.abstract?etoc

Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism

Shanshan Li, Selene K. Swanson, Madelaine Gogol, Laurence Florens, Michael P. Washburn, Jerry L. Workman, Tamaki Suganuma

http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00763-7

Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism

David E. Leib, Zachary A. Knight

http://www.cell.com/cell-reports/abstract/S2211-1247(15)01080-3

p53-regulated autophagy is controlled by glycolysis and determines cell fate

Lei Duan, Ricardo E. Perez, Batzaya Davaadelger, Elena N. Dedkova, Lothar A. Blatter and Carl G. Maki

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=5218

Cell type–specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors

Andrew C. Hsieh, Hao G. Nguyen, Lexiaochuan Wen, Merritt P. Edlind, Peter R. Carroll, Won Kim, and Davide Ruggero

http://stke.sciencemag.org/content/8/403/ra116.abstract

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation

K He, X Zheng, M Li, L Zhang and J Yu

http://www.nature.com/onc/journal/vaop/ncurrent/full/onc201579a.html

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition

Hai-Xin Yuan, Zhen Wang, Fa-Xing Yu, Fulong Li, Ryan C. Russell,Jenna L. Jewell, and Kun-Liang Guan

http://genesdev.cshlp.org/content/29/22/2362.abstract

-----------

AMPK

-----------

Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction

Bethany E. Schaffer, Rebecca S. Levin, Nicholas T. Hertz, Travis J. Maures, Michael L. Schoof, Pablo E. Hollstein, Bérénice A. Benayoun, Max R. Banko, Reuben J. Shaw, Kevan M. Shokat, Anne Brunet

http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00466-0

LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment

Christopher G. Peña, Yuji Nakada, Hatice D. Saatcioglu, Gina M. Aloisio, Ileana Cuevas, Song Zhang, David S. Miller, Jayanthi S. Lea, Kwok-Kin Wong, Ralph J. DeBerardinis, Antonio L. Amelio, Rolf A. Brekken, Diego H. Castrillon

http://www.jci.org/articles/view/82152

SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMPK-mTOR Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells

James L. Figarola, Jyotsana Singhal, Joshua D. Tompkins, George W. Rogers, Charles Warden, David Horne, Arthur D. Riggs, Sanjay Awasthi, and Sharad S. Singhal

http://www.jbc.org/content/early/2015/11/03/jbc.M115.686352.abstract

RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK

Yawei Zhao, Qingyang Wang, Guihua Qiu, Silei Zhou, Zhaofei Jing, Jingyang Wang, Wendie Wang, Junxia Cao, Kun Han, Qianqian Cheng, Beifen Shen, Yingyu Chen, Weiping J. Zhang, Yuanfang Ma, Jiyan Zhang

http://www.cell.com/cell-reports/abstract/S2211-1247(15)01165-1

-----------------------

Miscellaneous

-----------------------

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication

Minh Thai, Shivani K. Thaker, Jun Feng, Yushen Du, Hailiang Hu, Ting Ting Wu, Thomas G. Graeber, Daniel Braas and Heather R. Christofk

http://www.nature.com/ncomms/2015/151112/ncomms9873/full/ncomms9873.html

Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents

N Yadav, S Kumar, T Marlowe, A K Chaudhary, R Kumar, J Wang, J O'Malley, P M Boland, S Jayanthi, T K S Kumar, N Yadava and D Chandra

http://www.nature.com/cddis/journal/v6/n11/abs/cddis2015305a.html

Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency

M J Son, Y Kwon, M-Y Son, B Seol, H-S Choi, S-W Ryu, C Choi and Y S Cho