MetaboList - January 2015

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Muñoz Pinedo, Cristina

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Feb 1, 2015, 1:28:41 PM2/1/15

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Regards,

Cristina

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Cancer metabolism

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Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

Sophia Y. Lunt, Vinayak Muralidhar, Aaron M. Hosios, William J. Israelsen, Dan Y. Gui, Lauren Newhouse, Martin Ogrodzinski, Vivian Hecht, Kali Xu, Paula N. Marín Acevedo, Daniel P. Hollern, Gary Bellinger, Talya L. Dayton, Stefan Christen, Ilaria Elia, Anh T. Dinh, Gregory Stephanopoulos, Scott R. Manalis, Michael B. Yaffe, Eran R. Andrechek, Sarah-Maria Fendt, Matthew G. Vander Heiden

http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00837-5

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

Zachary T. Schug, Barrie Peck, Dylan T. Jones, Qifeng Zhang, Shaun Grosskurth, Israt S. Alam, Louise M. Goodwin, Elizabeth Smethurst, Susan Mason, Karen Blyth, Lynn McGarry, Daniel James, Emma Shanks, Gabriela Kalna, Rebecca E. Saunders, Ming Jiang, Michael Howell, Francois Lassailly, May Zaw Thin, Bradley Spencer-Dene, Gordon Stamp, Niels J.F. van den Broek, Gillian Mackay, Vinay Bulusu, Jurre J. Kamphorst, Saverio Tardito, David Strachan, Adrian L. Harris, Eric O. Aboagye, Susan E. Critchlow, Michael J.O. Wakelam, Almut Schulze, Eyal Gottlieb

http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00511-X

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

An S. Tan, James W. Baty, Lan-Feng Dong, Ayenachew Bezawork-Geleta, Berwini Endaya, Jacob Goodwin, Martina Bajzikova, Jaromira Kovarova, Martin Peterka, Bing Yan, Elham Alizadeh Pesdar, Margarita Sobol, Anatolyj Filimonenko, Shani Stuart, Magdalena Vondrusova, Katarina Kluckova, Karishma Sachaphibulkij, Jakub Rohlena, Pavel Hozak, Jaroslav Truksa, David Eccles, Larisa M. Haupt, Lyn R. Griffiths, Jiri Neuzil, Michael V. Berridge

http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00554-3

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo

Avinashnarayan Venkatanarayan, Payal Raulji, William Norton, Deepavali Chakravarti, Cristian Coarfa, Xiaohua Su, Santosh K. Sandur, Marc S. Ramirez, Jaehuk Lee, Charles V. Kingsley, Eliot F. Sananikone, Kimal Rajapakshe, Katherine Naff, Jan Parker-Thornburg, James A. Bankson, Kenneth Y. Tsai, Preethi H. Gunaratne & Elsa R. Flores

http://www.nature.com/nature/journal/v517/n7536/full/nature13910.html

Diet-Induced Unresolved ER Stress Hinders KRAS-Driven Lung Tumorigenesis

Giorgio Ramadori, Georgia Konstantinidou, Niranjan Venkateswaran, Tommasina Biscotti, Lorraine Morlock, Mirco Galié, Noelle S. Williams, Michele Luchetti, Alfredo Santinelli, Pier Paolo Scaglioni, Roberto Coppari

http://www.cell.com/cell-metabolism/abstract/S1550-4131%2814%2900551-8

Extracellular Metabolic Energetics Can Promote Cancer Progression

Jia Min Loo, Alexis Scherl, Alexander Nguyen, Fung Ying Man, Ethan Weinberg, Zhaoshi Zeng, Leonard Saltz, Philip B. Paty, Sohail F. Tavazoie

http://www.cell.com/cell/abstract/S0092-8674(14)01588-8

The Inhibitor Protein (IF1) of the F1F0-ATPase Modulates Human Osteosarcoma Cell Bioenergetics

Simona Barbato, Gianluca Sgarbi, Giulia Gorini, Alessandra Baracca, and Giancarlo Solaini

http://www.jbc.org/content/early/2015/01/20/jbc.M114.631788.abstract

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

Liang Zheng, Simone Cardaci, Livnat Jerby, Elaine D. MacKenzie, Marco Sciacovelli, T. Isaac Johnson, Edoardo Gaude, Ayala King, Joshua D. G. Leach, RuAngelie Edrada-Ebel, Ann Hedley, Nicholas A. Morrice, Gabriela Kalna, Karen Blyth, Eytan Ruppin, Christian Frezza and Eyal Gottlieb

http://www.nature.com/ncomms/2015/150123/ncomms7001/full/ncomms7001.html

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

Miranda Y. Fong, Weiying Zhou, Liang Liu, Aileen Y. Alontaga, Manasa Chandra, Jonathan Ashby, Amy Chow, Sean Timothy Francis O’Connor, Shasha Li, Andrew R. Chin, George Somlo, Melanie Palomares, Zhuo Li, Jacob R. Tremblay, Akihiro Tsuyada, Guoqiang Sun, Michael A. Reid, Xiwei Wu, Piotr Swiderski, Xiubao Ren, Yanhong Shi, Mei Kong, Wenwan Zhong, Yuan Chen & Shizhen Emily Wang

http://www.nature.com/ncb/journal/v17/n2/full/ncb3094.html

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Treatments

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Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells

Jing Li, Alfredo Csibi, Sun Yang, Gregory R. Hoffman, Chenggang Li, Erik Zhang, Jane J. Yu, and John Blenis

http://www.pnas.org/content/112/1/E21.abstract.html?etoc

Genetic Disruption of Lactate/H^+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin

Ibtissam Marchiq, Renaud Le Floch, Danièle Roux, Marie-Pierre Simon, and Jacques Pouyssegur

http://cancerres.aacrjournals.org/content/75/1/171.abstract?etoc

l-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

Matthew Fletcher, Maria E. Ramirez, Rosa A. Sierra, Patrick Raber, Paul Thevenot, Amir A. Al-Khami, Dulfary Sanchez-Pino, Claudia Hernandez, Dorota D. Wyczechowska, Augusto C. Ochoa, and Paulo C. Rodriguez

http://cancerres.aacrjournals.org/content/75/2/275.abstract?etoc

Dichloroacetate affects proliferation but not survival of human colorectal cancer cells

L. M. Delaney , N. Ho , J. Morrison , N. R. Farias , D. D. Mosser & B. L. Coomber

http://link.springer.com/article/10.1007/s10495-014-1046-4

Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells

Clint A. Stalnecker, Scott M. Ulrich, Yunxing Li, Sekar Ramachandran, Mary Kate McBrayer, Ralph J. DeBerardinis, Richard A. Cerione, and Jon W. Erickson

http://www.pnas.org/content/112/2/394.abstract.html?etoc

Blocking autophagy enhanced cytotoxicity induced by recombinant human arginase in triple-negative breast cancer cells

Z Wang, X Shi, Y Li, J Fan, X Zeng, Z Xian, Z Wang, Y Sun, S Wang, P Song, S Zhao, H Hu and D Ju

http://www.nature.com/cddis/journal/v5/n12/abs/cddis2014503a.html?WT.ec_id=CDDIS-201412

Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate

H Nilsson, D Lindgren, A Mandahl Forsberg, H Mulder, H Axelson and M E Johansson

http://www.nature.com/cddis/journal/v6/n1/abs/cddis2014545a.html

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mTOR

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Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Shuyu Wang, Zhi-Yang Tsun, Rachel L. Wolfson, Kuang Shen, Gregory A. Wyant, Molly E. Plovanich, Elizabeth D. Yuan, Tony D. Jones, Lynne Chantranupong, William Comb, Tim Wang, Liron Bar-Peled, Roberto Zoncu, Christoph Straub, Choah Kim, Jiwon Park, Bernardo L. Sabatini, and David M. Sabatini

http://www.sciencemag.org/content/347/6218/188.full?utm_source=eloqua

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Manuele Rebsamen, Lorena Pochini, Taras Stasyk, Mariana E. G. de Araújo, Michele Galluccio, Richard K. Kandasamy, Berend Snijder, Astrid Fauster, Elena L. Rudashevskaya, Manuela Bruckner, Stefania Scorzoni, Przemyslaw A. Filipek, Kilian V. M. Huber, Johannes W. Bigenzahn, Leonhard X. Heinz, Claudine Kraft, Keiryn L. Bennett, Cesare Indiveri, Lukas A. Huber & Giulio Superti-Furga

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14107.html

Differential regulation of mTORC1 by leucine and glutamine

Jenna L. Jewell, Young Chul Kim, Ryan C. Russell, Fa-Xing Yu, Hyun Woo Park, Steven W. Plouffe, Vincent S. Tagliabracci, Kun-Liang Guan

http://www.sciencemag.org/content/347/6218/194.full?utm_source=eloqua

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

Elena Rainero, Jonathan D. Howe, Patrick T. Caswell, Nigel B. Jamieson, Kurt Anderson, David R. Critchley, Laura Machesky, Jim C. Norman

http://www.cell.com/cell-reports/abstract/S2211-1247(14)01066-3

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

Young-Mi Kim, Chang Hwa Jung, Minchul Seo, Eun Kyoung Kim, Ji-Man Park, Sun Sik Bae, Do-Hyung Kim

http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00908-3

TORC1 Inhibition Induces Lipid Droplet Replenishment in Yeast

Juliana B. Madeira, Claudio A. Masuda, Clarissa M. Maya-Monteiro, Gabriel Soares Matos, Mónica Montero-Lomelí, and Bruno L. Bozaquel-Morais

http://mcb.asm.org/content/35/4/737.abstract?etoc

p53 suppresses carcinoma progression by inhibiting mTOR pathway activation

N Akeno, A L Miller, X Ma and K A Wikenheiser-Brokamp

http://www.nature.com/onc/journal/v34/n5/abs/onc2013589a.html

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Starvation, AMPK

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Autophagy mediates nonselective RNA degradation in starving yeast

Evelyn Welter and Zvulun Elazar

http://EMBOJ.embopress.org/content/34/2/131?etoc

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

Julianna Blagih, François Coulombe, Emma E. Vincent, Fanny Dupuy, Gabriela Galicia-Vázquez, Ekaterina Yurchenko, Thomas C. Raissi, Gerritje J.W. van der Windt, Benoit Viollet, Erika L. Pearce, Jerry Pelletier, Ciriaco A. Piccirillo, Connie M. Krawczyk, Maziar Divangahi, Russell G. Jones

http://www.cell.com/immunity/abstract/S1074-7613(14)00497-X

Polyamine Metabolism is Sensitive to Glycolysis Inhibition in Human Neuroblastoma Cells

M. Victoria Ruiz-Pérez, Miguel Ángel Medina, José Luis Urdiales, Tuomo A. Keinänen, and Francisca Sánchez-Jiménez

http://www.jbc.org/content/early/2015/01/15/jbc.M114.619197.abstract

ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway

Jong-Hyuk Lee, Hyonchol Jang, Soon-Min Lee, Ji-Eun Lee, Jinmi Choi, Tae Wan Kim, Eun-Jung Cho and Hong-Duk Youn

http://onlinelibrary.wiley.com/doi/10.1111/febs.13139/abstract?campaign=woletoc

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Hypoxia and HIFs

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HIF1α and HIF2α exert distinct nutrient preferences in renal cells.

Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK.

http://www.ncbi.nlm.nih.gov/pubmed/24879016

Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo

Xianchuang Zheng, Xin Wang, Hui Mao, Wei Wu, Baorui Liu and Xiqun Jiang

http://www.nature.com/ncomms/2015/150105/ncomms6834/full/ncomms6834.html

TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity

Marina Stantic, Habib A. M. Sakil, Hanna Zirath, Trixy Fang, Gema Sanz, Alejandro Fernandez-Woodbridge, Ana Marin, Evelyn Susanto, Tak W. Mak, Marie Arsenian Henriksson, and Margareta T. Wilhelm

http://www.pnas.org/content/112/1/220.abstract.html?etoc

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation

Ivano Amelio, Satoshi Inoue, Elke K. Markert, Arnold J. Levine, Richard A. Knight, Tak W. Mak, and Gerry Melino

http://www.pnas.org/content/112/1/226.abstract.html?etoc

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1a

Yoko Goto, Lihua Zeng, Chan Joo Yeom, Yuxi Zhu, Akiyo Morinibu, Kazumi Shinomiya, Minoru Kobayashi, Kiichi Hirota, Satoshi Itasaka, Michio Yoshimura, Keiji Tanimoto, Masae Torii, Terumasa Sowa, Toshi Menju, Makoto Sonobe, Hideaki Kakeya, Masakazu Toi, Hiroshi Date, Ester M. Hammond, Masahiro Hiraoka & Hiroshi Harada

http://www.nature.com/ncomms/2015/150123/ncomms7153/full/ncomms7153.html

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Miscellaneous

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VEGF-Targeted Therapy Stably Modulates the Glycolytic Phenotype of Tumor Cells

Matteo Curtarello, Elisabetta Zulato, Giorgia Nardo, Silvia Valtorta, Giulia Guzzo, Elisabetta Rossi, Giovanni Esposito, Aichi Msaki, Anna Pastò, Andrea Rasola, Luca Persano, Francesco Ciccarese, Roberta Bertorelle, Sergio Todde, Mario Plebani, Henrike Schroer, Stefan Walenta, Wolfgang Mueller-Klieser, Alberto Amadori, Rosa Maria Moresco, and Stefano Indraccolo

http://cancerres.aacrjournals.org/content/75/1/120.abstract?etoc

PFKFB4 controls embryonic patterning via Akt signalling independently of glycolysis

Caterina Pegoraro, Ana Leonor Figueiredo, Frédérique Maczkowiak, Celio Pouponnot, Alain Eychène and Anne H. Monsoro-Burq

http://www.nature.com/ncomms/2015/150120/ncomms6953/full/ncomms6953.html

Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila

Zachary J. Reitman, Sergey A. Sinenko, Eric P. Spana, and Hai Yan

http://www.bloodjournal.org/content/125/2/336.long

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Eva M. Palsson-McDermott, Anne M. Curtis, Gautam Goel, Mario A.R. Lauterbach, Frederick J. Sheedy, Laura E. Gleeson, Mirjam W.M. van den Bosch, Susan R. Quinn, Raquel Domingo-Fernandez, Daniel G.W. Johnson, Jain-kang Jiang, William J. Israelsen, Joseph Keane, Craig Thomas, Clary Clish, Matthew Vanden Heiden, Ramnik J. Xavier, Luke A.J. O’Neill

http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00556-7

Loss of autophagy causes a synthetic lethal deficiency in DNA repair

Emma Y. Liu, Naihan Xu, Jim O’Prey, Laurence Y. Lao, Sanket Joshi, Jaclyn S. Long, Margaret O’Prey, Daniel R. Croft, Florian Beaumatin, Alice D. Baudot, Michaela Mrschtik, Mathias Rosenfeldt, Yaou Zhang, David A. Gillespie, and Kevin M. Ryan

http://www.pnas.org/content/112/3/773.abstract.html?etoc

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Valerie A. Gerriets, Rigel J. Kishton, Amanda G. Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, Xiaojing Liu, Bhavana Priyadharshini, Marta E. Slawinska, Lea Haeberli, Catherine Huck, Laurence A. Turka, Kris C. Wood, Laura P. Hale, Paul A. Smith, Martin A. Schneider, Nancie J. MacIver, Jason W. Locasale, Christopher B. Newgard, Mari L. Shinohara, Jeffrey C. Rathmell

http://www.jci.org/articles/view/76012

Rapid Analysis of Glycolytic and Oxidative Substrate Flux of Cancer Cells in a Microplate

Lisa S. Pike Winer, Min Wu

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109916

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Reviews

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Nutrient-sensing mechanisms and pathways

Alejo Efeyan, William C. Comb, David M. Sabatini

http://www.nature.com/nature/journal/v517/n7534/full/nature14190.html

The role for autophagy in cancer

Eileen White

http://www.jci.org/articles/view/73941

Autophagy in cellular metabolism and cancer

Xuejun Jiang, Michael Overholtzer, Craig B. Thompson

http://www.jci.org/articles/view/73942

Lon protease: A key enzyme controlling mitochondrial bioenergetics in cancer

Pedro M Quirós, Clea Bárcena & Carlos López-Otín

http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.968505

Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one

Aleksandra Pandyra & Linda Z Penn

http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.969133

Cellular and metabolic functions for autophagy in cancer cells

Candia M. Kenific, Jayanta Debnath

http://www.cell.com/trends/cell-biology/abstract/S0962-8924(14)00158-5

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis

Ekihiro Seki

http://www.tandfonline.com/doi/abs/10.4161/23723548.2014.968507?ai=1gumh&ui=79l0u&af=T

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

D J Roberts and S Miyamoto

http://www.nature.com/cdd/journal/v22/n2/abs/cdd2014173a.html?WT.ec_id=CDD-201502

mTOR: a pharmacologic target for autophagy regulation

Young Chul Kim, Kun-Liang Guan

http://www.jci.org/articles/view/73939

Pluripotent stem cell energy metabolism: an update

Tara Teslaa and Michael A Teitell

http://EMBOJ.embopress.org/content/34/2/138?etoc

The role of hypoxia-inducible factor-2 in digestive system cancers

J Zhao, F Du, G Shen, F Zheng and B Xu

http://www.nature.com/cddis/journal/v6/n1/abs/cddis2014565a.html

Current treatment strategies for inhibiting mTOR in cancer

Francesca Chiarini, Camilla Evangelisti, James A. McCubrey, Alberto M. Martelli

http://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147(14)00195-3

Redox control of glutamine utilization in cancer

L Alberghina and D Gaglio

http://www.nature.com/cddis/journal/v5/n12/abs/cddis2014513a.html?WT.ec_id=CDDIS-201412

Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways

Hanne R. Hagland, Kjetil Søreide

http://www.cancerletters.info/article/S0304-3835(14)00133-5/abstract

Biochemical Pharmacology

Special issue Edited by Marc Diederich

"Alterations of Metabolic Pathways as Therapeutic Targets"

http://www.sciencedirect.com/science/journal/00062952/92/1

Including,

- Glycogen metabolism in cancer

Christos E. Zois, Elena Favaro, Adrian L. Harris

- Heterogeneity of glycolysis in cancers and therapeutic opportunities

Marc O. Warmoes, Jason W. Locasale

- Modulatory roles of glycolytic enzymes in cell death

Claudia Cerella, Mario Dicato, Marc Diederich

- Metabolic orchestration between cancer cells and tumor microenvironment as a co-evolutionary source of chemoresistance in ovarian cancer: A therapeutic implication

Dong Hoon Suh, Hee Seung Kim, Boyun Kim, Yong Sang Song

- Mitochondrial dysfunction in cancer chemoresistance

Nicoletta Guaragnella, Sergio Giannattasio, Loredana Moro

- Targeting antioxidants for cancer therapy

Andrea Glasauer, Navdeep S. Chandel

- Energy restriction mimetic agents to target cancer cells: Comparison between 2-deoxyglucose and thiazolidinediones

Sandra Kuntz, Sabine Mazerbourg, Michel Boisbrun, Claudia Cerella, Marc Diederich, Isabelle Grillier-Vuissoz, Stephane Flament

- PARP and other prospective targets for poisoning cancer cell metabolism

Judith Michels, Florine Obrist, Maria Castedo, Ilio Vitale, Guido Kroemer

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Comments

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