MetaboList - October II

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Muñoz Pinedo, Cristina

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Nov 2, 2016, 12:49:32 PM11/2/16

to cancerme...@googlegroups.com

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Metabolism and metastasis

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Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

Stefan Christen, Doriane Lorendeau, Roberta Schmieder, Dorien Broekaert, Kristine Metzger, Koen Veys, Ilaria Elia, Joerg Martin Buescher, Martin Franz Orth, Shawn Michael Davidson, Thomas Georg Philipp Grünewald, Katrien De Bock, Sarah-Maria Fendt

http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31281-5

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

Edoardo Gaude and Christian Frezza

http://www.nature.com/articles/ncomms13041

Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo

Hyein Jeon, Jae Hwan Kim, Eunjung Lee, Young Jin Jang, Joe Eun Son, Jung Yeon Kwon, Tae-gyu Lim, Sunghoon Kim, Jung Han Yoon Park, Jong-Eun Kim, and Ki Won Lee

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=11615

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Metabolism, cancer and the immune system

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Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

Mathias Wenes, Min Shang, Mario Di Matteo, Jermaine Goveia, Rosa Martín-Pérez, Jens Serneels, Hans Prenen, Bart Ghesquière, Peter Carmeliet, Massimiliano Mazzone

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30488-0

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Roger Geiger, Jan C. Rieckmann, Tobias Wolf, Camilla Basso, Yuehan Feng, Tobias Fuhrer, Maria Kogadeeva, Paola Picotti, Felix Meissner, Matthias Mann, Nicola Zamboni, Federica Sallusto, Antonio Lanzavecchia

http://www.cell.com/cell/abstract/S0092-8674(16)31313-7

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Glucose metabolism

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Hyaluronan production regulates metabolic and cancer stem-like properties of breast cancer cells via hexosamine biosynthetic pathway-coupled HIF-1 signaling

Theerawut Chanmee, Pawared Ontong, Tomomi Izumikawa, Miho Higashide, Nobutoshi Mochizuki, Chatchadawalai Chokchaitaweesuk, Manatsanan Khansai, Kazuki Nakajima, Ikuko Kakizaki, Prachya Kongtawelert, Naoyuki Taniguchi, and Naoki Itano

http://www.jbc.org/content/early/2016/10/06/jbc.M116.751263.abstract

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

Marie-Julie Nokin, Florence Durieux, Paul Peixoto, Barbara Chiavarina, Olivier Peulen, Arnaud Blomme, Andrei Turtoi, Brunella Costanza, Nicolas Smargiasso, Dominique Baiwir, Jean L Scheijen, Casper G Schalkwijk, Justine Leenders, Pascal De Tullio, Elettra Bianchi, Marc Thiry, Koji Uchida, David A Spiegel, James R Cochrane, Craig A Hutton, Edwin De Pauw, Philippe Delvenne, Dominique Belpomme, Vincent Castronovo and Akeila Bellahcène

https://elifesciences.org/content/5/e19375

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Amino acids

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Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells

Bradley Smith, Xenia L. Schafer, Aslihan Ambeskovic, Cody M. Spencer, Hartmut Land, Joshua Munger

http://www.cell.com/cell-reports/abstract/S2211-1247(16)31284-0

A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas

Gregory R Bean, Jeff C Kremer, Bethany C Prudner, Aaron D Schenone, Juo-Chin Yao, Matthew B Schultze, David Y Chen, Munir R Tanas, Douglas R Adkins, John Bomalaski, Brian P Rubin, Loren S Michel and Brian A Van Tine

http://www.nature.com/cddis/journal/v7/n10/abs/cddis2016232a.html

Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells

Elina Timosenko, Hemza Ghadbane, Jonathan D. Silk, Dawn Shepherd, Uzi Gileadi, Lauren J. Howson, Robert Laynes, Qi Zhao, Robert L. Strausberg, Lars R. Olsen, Stephen Taylor, Francesca M. Buffa, Richard Boyd, and Vincenzo Cerundolo

http://cancerres.aacrjournals.org/content/76/21/6193.abstract?etoc

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Mitochondria

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The Assembly Pathway of Mitochondrial Respiratory Chain Complex I

Sergio Guerrero-Castillo, Fabian Baertling, Daniel Kownatzki, Hans J. Wessels, Susanne Arnold, Ulrich Brandt, Leo Nijtmans

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30480-6

Atomic structure of the entire mammalian mitochondrial complex I

Karol Fiedorczuk,James A. Letts,Gianluca Degliesposti,Karol Kaszuba,Mark Skehel&Leonid A. Sazanov

http://www.nature.com/nature/journal/v538/n7625/full/nature19794.html

Mechanism of super-assembly of respiratory complexes III and IV

Sara Cogliati, Enrique Calvo, Marta Loureiro, Adela M. Guaras, Rocio Nieto-Arellano, Carolina Garcia-Poyatos, Iakes Ezkurdia, Nadia Mercader, Jesús Vázquez & José Antonio Enriquez

http://www.nature.com/nature/journal/vaap/ncurrent/full/nature20157.html

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

Jason D. Arroyo, Alexis A. Jourdain, Sarah E. Calvo, Carmine A. Ballarano, John G. Doench, David E. Root, Vamsi K. Mootha

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30433-8

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Lipids and acetate

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ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

Steven Zhao, AnnMarie Torres, Ryan A. Henry, Sophie Trefely, Martina Wallace, Joyce V. Lee, Alessandro Carrer, Arjun Sengupta, Sydney L. Campbell, Yin-Ming Kuo, Alexander J. Frey, Noah Meurs, John M. Viola, Ian A. Blair, Aalim M. Weljie, Christian M. Metallo, Nathaniel W. Snyder, Andrew J. Andrews, Kathryn E. Wellen

http://www.cell.com/cell-reports/abstract/S2211-1247(16)31325-0

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.

Ru P, Hu P, Geng F, Mo X, Cheng C, Yoo JY, Cheng X, Wu X, Guo JY, Nakano I, Lefai E, Kaur B, Chakravarti A, Guo D.

http://www.cell.com/cell-reports/abstract/S2211-1247(16)30903-2

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis.

Geng F, Cheng X, Wu X, Yoo JY, Cheng C, Guo JY, Mo X, Ru P, Hurwitz B, Kim SH, Otero J, Puduvalli V, Lefai E, Ma J, Nakano I, Horbinski C, Kaur B, Chakravarti A, Guo D.

http://clincancerres.aacrjournals.org/content/22/21/5337.long

Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer

Katherine L. Cook, David R. Soto-Pantoja, Pamela A.G. Clarke, M. IdaliaCruz, Alan Zwart, Anni Wärri, Leena Hilakivi-Clarke, David D. Roberts, and Robert Clarke

http://cancerres.aacrjournals.org/content/76/19/5657.abstract?etoc

Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications

Suellen Ferro, João Azevedo-Silva, Margarida Casal, Manuela Côrte-Real, Fatima Baltazar, Ana Preto

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=12156

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Epigenetics

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Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

Min Pan, Michael A. Reid, Xazmin H. Lowman, Rajan P. Kulkarni, Thai Q. Tran, Xiaojing Liu4, Ying Yang1, Jenny E. Hernandez-Davies1, Kimberly K. Rosales1, Haiqing Li5, Willy Hugo, Chunying Song, Xiangdong Xu, Dustin E. Schones, David K. Ann, Viviana Gradinaru, Roger S. Lo, Jason W. Locasale, Mei Kong

http://www.nature.com/ncb/journal/v18/n10/full/ncb3410.html

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase

Xiaozhen He, Bin Yan, Shuang Liu, Jiantao Jia, Weiwei Lai, Xing Xin, Can-e Tang, Dixian Luo, Tan Tan, Yiqun Jiang, Ying Shi, Yating Liu, Desheng Xiao, Ling Chen, Shao Liu, Chao Mao, Gang Yin, Yan Cheng, Jia Fan, Ya Cao, Kathrin Muegge, and Yongguang Tao

http://cancerres.aacrjournals.org/content/76/19/5743.abstract?etoc

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

Eoin McDonnell, Scott B. Crown, Douglas B. Fox, Betül Kitir, Olga R. Ilkayeva, Christian A. Olsen, Paul A. Grimsrud, Matthew D. Hirschey

http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31398-5

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Nutrient sensing / starvation

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Structural reverse genetics study of the PI5P4Kβ–nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells

Koh Takeuchi, Miki Senda, Yu-Hua Lo, Satoshi Kofuji, Yoshiki Ikeda, Atsuo T. Sasaki and Toshiya Senda

http://onlinelibrary.wiley.com/doi/10.1111/febs.13739/abstract

Dynamics of mTORC1 activation in response to amino acids

Maria Manifava, Matthew Smith, Sergio Rotondo, Simon Walker, Izabella Niewczas, Roberto Zoncu, Jonathan Clark and Nicholas T Ktistakis

https://elifesciences.org/content/5/e19960

Selective endosomal microautophagy is starvation-inducible in Drosophila

Anindita Mukherjee, Bindi Patel, Hiroshi Koga, Ana Maria Cuervo & Andreas Jenny

http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1208887

Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation

Giulia Allavena, Caroline Boyd, Kyaw Soe Oo, Emilia Maellaro, Boris Zhivotovsky & Vitaliy O. Kaminskyy

http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1226733

[not sure what the stimuli are, in these two articles]

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mTOR / AMPK

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Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells

Yijiang Shi, Tracy R. Daniels-Wells, Patrick Frost, Jihye Lee, Richard S.Finn, Carolyne Bardeleben, Manuel L. Penichet, Michael E. Jung, JosephGera, and Alan Lichtenstein

http://cancerres.aacrjournals.org/content/76/19/5822.abstract?etoc

Metformin Activates AMPK through the Lysosomal Pathway

Chen-Song Zhang, Mengqi Li, Teng Ma, Yue Zong, Jiwen Cui, Jin-Wei Feng, Yu-Qing Wu, Shu-Yong Lin, Sheng-Cai Lin

http://www.cell.com/cell-metabolism/abstract/S1550-4131(16)30481-8

AMPK promotes tolerance to Ras pathway inhibition by activating autophagy

S Sanduja, Y Feng, R A Mathis, E S Sokol, F Reinhardt, R Halaban and P B Gupta

http://www.nature.com/onc/journal/v35/n40/full/onc201670a.html

Nrf2 transcription factor can directly regulate mTOR; linking cytoprotective gene expression to a major metabolic regulator that generates redox activity

Gabriel Bendavit, Tahar Aboulkassim, Khalid Hilmi, Sujay Shah, and Gerald Batist

http://www.jbc.org/content/early/2016/10/26/jbc.M116.760249.abstract

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Obesity / diet

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Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

Ryan Kolb, Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M. Janowski, Qing Xie, Kathleen R. Markan, Wei Li, Matthew J. Potthoff, Enrique Fuentes-Mattei, Lesley G. Ellies, C. Michael Knudson, Mong-Hong Lee, Sai-Ching J. Yeung, Suzanne L. Cassel, Fayyaz S. Sutterwala and Weizhou Zhang

http://www.nature.com/articles/ncomms13007

Dietary energy restriction reduces high-fat diet-enhanced metastasis of Lewis lung carcinoma in mice

Sneha Sundaram, and Lin Yan

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=11598

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Miscellaneous

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Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons

Saori R. Yoshii, Akiko Kuma, Takumi Akashi, Taichi Hara, Atsushi Yamamoto, Yoshitaka Kurikawa, Eisuke Itakura, Satoshi Tsukamoto, Hiroshi Shitara, Yoshinobu Eishi, Noboru Mizushima

http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30597-4

Coordinated Activities of Multiple Myc-Dependent and Myc-Independent Biosynthetic Pathways in Hepatoblastoma

Huabo Wang, Jie Lu, Lia R. Edmeunds, Sucheta Kulkarni, James Dolezal, Junyan Tao, Sarangarajan Ranganathan, Laura Jackson, Marc Fromherz, Donna Beer Stolz, Radha Uppala, Sivakama Bharathi, Satdarshan P. Monga, Eric S. Goetzman, and Edward V. Prochownik

http://www.jbc.org/content/early/2016/10/13/jbc.M116.754218.abstract

An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice

Maria Rohm, Michaela Schäfer, Victor Laurent, Bilgen Ekim Üstünel, Katharina Niopek, Carolyn Algire, Oksana Hautzinger, Tjeerd P Sijmonsma, Annika Zota, Dasa Medrikova, Natalia S Pellegata, Mikael Ryden, Agné Kulyte, Ingrid Dahlman,Peter Arner, Natasa Petrovic, Barbara Cannon, Ez-Zoubir Amri, Bruce E Kemp, Gregory R Steinberg, Petra Janovska, Jan Kopecky, Christian Wolfrum, Matthias Blüher, Mauricio Berriel Diaz & Stephan Herzig

http://www.nature.com/nm/journal/v22/n10/full/nm.4171.html

Activation of AMP-Activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells

Luciano Galdieri, Himavanth Gatla, Ivana Vancurova, and Ales Vancura

http://www.jbc.org/content/early/2016/10/12/jbc.M116.742247.abstract

Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis

Chiara Bardella, Osama Al-Dalahmah, Daniel Krell, Pijus Brazauskas, Khalid Al-Qahtani, Marketa Tomkova, Julie Adam, Sébastien Serres, Helen Lockstone, Luke Freeman-Mills, Inga Pfeffer, Nicola Sibson, Robert Goldin, Benjamin Schuster-Böeckler, Patrick J. Pollard, Tomoyoshi Soga, James S. McCullagh, Christopher J. Schofield, Paul Mulholland, Olaf Ansorge, Skirmantas Kriaucionis, Peter J. Ratcliffe, Francis G. Szele, Ian Tomlinson

http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30402-0

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Comments

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Blocking fatty acid synthesis reduces lung tumor growth in mice

Jiyeon Kim and Ralph J DeBerardinis

http://www.nature.com/nm/journal/v22/n10/full/nm.4195.html

Targeting HIF2α in Clear-Cell Renal Cell Carcinoma

Christopher J. Ricketts, Daniel R. Crooks, W. Marston Linehan

http://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30451-2

Warburg meets epigenetics

Chirag H. Patel, Jonathan D. Powell